A5004462514- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Genetic Associations and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health, Environment, Cognitive Aging
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Statistical Methods and Inference
- Bioinformatics and Genomic Networks
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neonatal and fetal brain pathology
- Genomic variations and chromosomal abnormalities
- Statistical Methods in Clinical Trials
- Bipolar Disorder and Treatment
- Pain Management and Placebo Effect
- Epigenetics and DNA Methylation
- Multiple Sclerosis Research Studies
National Institutes of Health
2018-2025
National Institute of Mental Health
2018-2025
The University of Texas Rio Grande Valley
2022-2025
National Institute of Mental Health
2020-2025
Pfizer (United States)
2021-2024
Humboldt-Universität zu Berlin
2024
University of Oxford
2014-2023
Great Ormond Street Hospital
2022
SickKids Foundation
2022
Hospital for Sick Children
2022
Permutation methods can provide exact control of false positives and allow the use non-standard statistics, making only weak assumptions about data. With availability fast inexpensive computing, their main limitation would be some lack flexibility to work with arbitrary experimental designs. In this paper we report on results approximate permutation that are more flexible respect design nuisance variables, conduct detailed simulations identify best method for settings typical imaging...
There is strong evidence of brain-related abnormalities in COVID-19
Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete characterization of thalamic connectivity in schizophrenia limits our understanding its relationship to symptoms and diagnoses shared clinical presentation, such as bipolar illness, which exist on spectrum. Using resting-state functional magnetic resonance imaging, we characterized 90 patients versus matched controls via:...
The default-mode network, a coherent resting-state brain is thought to characterize basal neural activity. Aberrant connectivity has been reported in host of neurological and psychiatric illnesses persons at genetic risk for such illnesses. Whereas the neurophysiologic mechanisms that regulate are unclear, there growing evidence factors play role. In this report, we estimate importance effects on network by examining covariation patterns functional among 333 individuals from 29 randomly...
Permutation tests are increasingly being used as a reliable method for inference in neuroimaging analysis. However, they computationally intensive. For small, non-imaging datasets, recomputing model thousands of times is seldom problem, but large, complex models this can be prohibitively slow, even with the availability inexpensive computing power. Here we exploit properties statistics general linear (GLM) and their distributions to obtain accelerations irrespective generic software or...
Under weak and reasonable assumptions, mainly that data are exchangeable under the null hypothesis, permutation tests can provide exact control of false positives allow use various non-standard statistics. There are, however, common examples in which global exchangeability be violated, including paired tests, involve repeated measurements, subjects relatives (members pedigrees) - any dataset with known dependence among observations. In these cases, some permutations, if performed, would...
Abstract In this work, we show how permutation methods can be applied to combination analyses such as those that include multiple imaging modalities, data acquisitions of the same modality, or simply hypotheses on data. Using well‐known definition union‐intersection tests and closed testing procedures, use synchronized permutations correct for multiplicity tests, allowing flexibility integrate with different spatial resolutions, surface and/or volume‐based representations brain, including...
Anodal transcranial direct current stimulation (tDCS) can boost the effects of motor training and facilitate plasticity in healthy human brain. Motor rehabilitation depends on learning plasticity, occur after stroke. We tested whether brain using anodal tDCS added to could improve outcomes patients performed a randomized, controlled trial 24 at least 6 months first unilateral stroke not directly involving primary cortex. Patients received either (n= 11) or sham treatment 13) paired with...
Abstract There is strong evidence for brain-related abnormalities in COVID-19 1–13 . It remains unknown however whether the impact of SARS-CoV-2 infection can be detected milder cases, and this reveal possible mechanisms contributing to brain pathology. Here, we investigated changes 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive with between their two scans, 141 days on average separating diagnosis second scan, 384 controls. The availability...
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
Patterns of intrinsic human brain activity exhibit a profile functional connectivity that is associated with behaviour and cognitive performance, deteriorates disease. This paper investigates the relative importance genetic factors common environment between twins in determining this profile. Using magnetic resonance imaging (fMRI) on 820 subjects from Human Connectome Project, magnetoencephalographic (MEG) recordings subset, heritability among 39 cortical regions was estimated. On average...
Cortical surface area is an increasingly used brain morphology metric that ontogenetically and phylogenetically distinct from cortical thickness offers a separate index of neurodevelopment disease. However, the various existing methods for assessment magnetic resonance images have never been systematically compared. We show method implemented in FreeSurfer corresponds closely to exact, but computationally more demanding, mass-conservative (pycnophylactic) method, provided are smoothed. Thus,...
Both sleep disturbances and decline in white matter microstructure are commonly observed ageing populations, as well age-related psychiatric neurological illnesses. A relationship between may underlie such relationships, but few imaging studies have directly examined this hypothesis. In a study of 448 community-dwelling members the Whitehall II Imaging Sub-Study aged 60 82 years (90 female, mean age 69.2 ± 5.1 years), we used magnetic resonance technique diffusion tensor to examine...
Abstract In the dawning era of large-scale biomedical data, multidimensional phenotype vectors will play an increasing role in examining genetic underpinnings brain features, behaviour and disease. For example, shape measurements derived from MRI scans are geometric descriptions structure provide alternate class phenotypes that remains largely unexplored studies. Here we extend concept heritability to traits, present first comprehensive analysis neuroanatomical across ensemble structures...