A5084276191- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Substance Abuse Treatment and Outcomes
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Forensic Toxicology and Drug Analysis
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Opioid Use Disorder Treatment
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Child and Adolescent Psychosocial and Emotional Development
- Heart Rate Variability and Autonomic Control
- Prenatal Substance Exposure Effects
- Nicotinic Acetylcholine Receptors Study
- Alcohol Consumption and Health Effects
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Mind wandering and attention
Icahn School of Medicine at Mount Sinai
2016-2025
Allen Institute for Brain Science
2014-2023
New York Proton Center
2019
University of Oregon
2018
The University of Melbourne
2018
Orygen
2018
University of Vermont
2018
Media Working Group
2018
Imaging Center
2017
Yale University
2017
Obesity has been associated with a higher risk for impaired cognitive function, which most likely reflects medical complications (i.e., cerebrovascular pathology). However, there is also evidence that in healthy individuals excess weight may adversely affect cognition (executive attention, and memory). Here, we measured regional brain glucose metabolism (using positron emission tomography (PET) 2-deoxy-2[(18)F]fluoro-D-glucose (FDG)) to assess the relationship between BMI (marker of...
Although lower brain volume has been routinely observed in individuals with substance dependence compared nondependent control subjects, the regions exhibiting have not consistent across studies. In addition, it is clear whether a common set of are involved regardless used or some effects specific. Resolution these issues may contribute to identification clinically relevant imaging biomarkers. Using pooled data from 14 countries, authors sought identify general and substance-specific...
The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Therefore, a common polymorphism in MAO gene (MAOA, Mendelian Inheritance Men database number 309850, referred to as high or low based on transcription non-neuronal cells) has been investigated externalizing behavioral clinical phenotypes. These studies provide evidence linking MAOA genotype violent...
Anterior cingulate cortex (ACC) hypoactivations during cognitive processing characterize drug addicted individuals as compared with healthy controls. However, impaired behavioral performance or task disengagement may be crucial factors. We hypothesized that ACC would documented in groups matched for on an emotionally salient task. Seventeen current cocaine use disorders (CUD) and 17 demographically controls underwent functional magnetic resonance imaging of a rewarded cue-reactivity...
Event-related potentials (ERPs) are a direct measure of neural activity and ideally suited to study the time-course attentional engagement with emotional drug-related stimuli in addiction. In particular, late positive potential (LPP) appears be enhanced following cocaine-related compared neutral human participants cocaine use disorders (CUD). However, previous studies have not directly while examining differences between abstinent current users. The present examined ERPs 55 CUD (27 28 users)...
Objective: This study attempted to examine the brain's sensitivity monetary rewards of different magnitudes in cocaine abusers and its association with motivation self-control. Method: Sixteen 13 matched healthy comparison subjects performed a forced-choice task under three value conditions while brain activation was measured functional magnetic resonance imaging. Objective measures state were assessed by reaction time accuracy, subjective self-reports engagement. Measures trait self-control...
When exposed to drug conditioned cues (stimuli associated with the drug), addicted individuals experience an intense desire for drug, which is increased dopamine cell firing. We hypothesized that drug-related words can trigger activation in mesencephalon, where dopaminergic cells are located. During functional magnetic resonance imaging (fMRI), 15 cocaine use disorders and demographically matched healthy control subjects pressed buttons color of versus neutral words. Results showed words,...
The authors investigated cortico-striatal reactivity to drug cues (as compared with neutral and food cues), cue reappraisal, savoring, their correlations heroin craving in individuals use disorder healthy control subjects.
Opioid use disorder (OUD) causes major public health morbidity and mortality. Although standard-of-care treatment with medications for OUD (MOUDs) is available, there are few biological markers of the clinical process recovery. Neurobiological aspects recovery can include normalization brain white matter (WM) microstructure, which sensitive to cytokine signaling. Here, we determined whether blood-based cytokines be change in WM microstructure following MOUD. Inpatient individuals heroin...
Background Chronic cocaine use is associated with disrupted dopaminergic neurotransmission but how this disruption affects overall brain function (other than reward/motivation) yet to be fully investigated. Here we test the hypothesis that addicted subjects will have functional connectivity between midbrain (where dopamine neurons are located) and cortical subcortical regions during performance of a sustained attention task. Methodology/Principal Findings We measured activation fMRI in 20...