A5103125643- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Mind wandering and attention
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Transcranial Magnetic Stimulation Studies
- Diet and metabolism studies
- Neural dynamics and brain function
- History of Medical Practice
- Parkinson's Disease Mechanisms and Treatments
- Vestibular and auditory disorders
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Health, Environment, Cognitive Aging
- Opioid Use Disorder Treatment
- Decision-Making and Behavioral Economics
- Meta-analysis and systematic reviews
- Memory and Neural Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Icahn School of Medicine at Mount Sinai
2018-2021
Imaging Center
2018
Brookhaven National Laboratory
2006-2013
The US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. RDoC framework comprises 39 functional constructs designed be revised refined, with the overall goal improving diagnostic validity treatments. This study aimed reach a consensus among experts in addiction field on 'primary' most relevant substance behavioural addictions.Forty-four were...
Abstract Low levels of dopamine (DA) D2 receptor availability at a resting baseline have been previously reported in drug addicted individuals and associated with reduced ventral dorsal prefrontal metabolism. The reduction DA along the frontal metabolism is thought to underlie compromised sensitivity nondrug reward, core characteristic addiction. We therefore hypothesized that variability will covary dynamic responses monetary reward individuals. Striatal was measured [ 11 C]raclopride...
Abstract Background Drug-related memories can hinder abstinence goals in drug addiction. Promoting non-drug via ventromedial prefrontal cortex- (vmPFC) and amygdala-guided extinction yields mixed success. Post-retrieval (RE) destabilizes updates during reconsolidation, improving extinction. Supplementing RE, we tested methylphenidate (MPH), a dopamine-agonist that promotes PFC-dependent learning memory cocaine use disorder (CUD). In an Early Phase 1 double-blind randomized clinical trial...
Impaired inhibitory control accompanied by enhanced salience attributed to drug-related cues, both associated with function of the dorsolateral prefrontal cortex (dlPFC), are hallmarks drug addiction, contributing worse symptomatology including craving. dlPFC modulation transcranial direct current stimulation (tDCS) previously showed craving reduction in inpatients cocaine use disorder (CUD). Our study aimed at assessing feasibility a longer tDCS protocol CUD (15 versus common five/10...
Abstract Background Cue reactivity is one of the most frequently used paradigms in functional magnetic resonance imaging (fMRI) studies substance use disorders (SUDs). While there have been promising results elucidating neurocognitive mechanisms SUDs and SUD treatments, interpretability reproducibility these limited by incomplete reporting participant characteristics, task design, craving assessment, scanning preparation analysis decisions fMRI drug cue (FDCR) experiments. This hampers...
Abstract Question The opioid epidemic causes massive morbidity, and males have substantially greater overdose mortality rates than females. It is unclear whether there are sex-related disparities at different stages in the trajectory of use disorders, “real world” settings. Goal To determine sex non-medical (NMOU) end outpatient medication-assisted treatment (MAT), using nationally representative data. Design Observational epidemiological study publicly funded MAT programs national...
Abstract Impaired inhibitory control accompanied by enhanced salience attributed to drug-related cues, both dorsolateral prefrontal cortex (dlPFC) functions, are hallmarks of drug addiction, contributing worse symptomatology including craving. dlPFC modulation with transcranial direct current stimulation (tDCS) showed craving reduction in inpatients cocaine use disorder (CUD). Our study aimed at assessing feasibility a longer tDCS protocol CUD (15 vs. the common five/10 sessions), and...