A5084353177- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Sleep and Wakefulness Research
- Prenatal Substance Exposure Effects
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Memory and Neural Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Nicotinic Acetylcholine Receptors Study
- Neuroscience, Education and Cognitive Function
- Smoking Behavior and Cessation
- Behavioral Health and Interventions
- Sleep and related disorders
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Forensic Toxicology and Drug Analysis
The University of Texas at Dallas
2016-2025
University of Dallas
2019
The University of Texas Southwestern Medical Center
1999-2018
Duke Medical Center
2017
Mind Research Network
2008-2011
University of Colorado Boulder
2006-2011
National Institutes of Health
2006-2010
King's College London
2008-2010
University of New Mexico
2009-2010
University of Cambridge
2008
As the size of functional and structural MRI datasets expands, it becomes increasingly important to establish a baseline from which diagnostic relevance may be determined, processing strategy that efficiently prepares data for analysis, statistical approach identifies effects in manner is both robust reproducible. In this paper, we introduce multivariate analytic optimizes sensitivity reduces unnecessary testing. We demonstrate utility mega-analytic by identifying age gender on resting state...
Questions surrounding the effects of chronic marijuana use on brain structure continue to increase. To date, however, findings remain inconclusive. In this comprehensive study that aimed characterize alterations associated with use, we measured gray matter (GM) volume via structural MRI across whole by using voxel-based morphology, synchrony among abnormal GM regions during resting state functional connectivity MRI, and white integrity (i.e., connectivity) between diffusion tensor imaging in...
Craving is one of the primary behavioral components drug addiction, and cue-elicited craving an especially powerful form this construct. While its underlying neurobiological mechanisms have been extensively studied with respect to alcohol other drugs abuse, same cannot be said for marijuana. Cue-elicited abuse associated increased activity in a number brain areas, particularly reward pathway. This study used functional magnetic resonance imaging (fMRI) examine Thirty-eight regular marijuana...
OBJECTIVE: Schizophrenia and psychotic bipolar disorder have a number of overlapping symptoms risk factors, but it is not yet clear if the disorders are characterized by similar deviations in brain morphometry or whether any such reflect impact shared susceptibility genes on structure. The authors used region-of-interest to volumetrically assess structures frequently implicated illness families affected with schizophrenia disorder. METHOD: Magnetic resonance imaging scans were obtained from...
Background: Studies suggest that polymorphisms in the D4 dopamine receptor (DRD4) and opioid receptor, μ1 (OPRM1) genes are involved differential response to effects of alcohol cues. However, date, mechanisms underlie these differences remain largely unknown. Methods: Using functional magnetic resonance imaging, hemodynamic mesocorticolimbic structures after exposure tastes was contrasted with a control taste compared between DRD4 variable number tandem repeats (VNTR) genotypes OPRM1 A118G...
The val66 met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for BDNF polymorphism. We analyzed effect on using Wechsler Memory Scale, revised version (WMS-R) by regression analysis between WMS delayed score logical genotype...
Context: Given the probable importance of ␣4 subunit neuronal nicotinic acetylcholine receptor, gene that codes for this (CHRNA4) represents an excellent starting point a genetic investigation smoking behavior.Objective: To achieve better understanding role in cause and treatment tobacco dependence, we adopted transdisciplinary pharmacogenetic approach.Design: Study at behavioral clinical levels analysis.Setting: Academic research.Participants: Smokers (n=316) between ages 18 50 years were...
Context-The gene that codes for cannabinoid receptor 1 (CNR1) represents an important target investigations designed to elucidate individual differences in the etiology of alcohol dependence.Objective-To achieve a better understanding role CNR1 and treatment dependence.Design-The present investigation spans multiple levels analysis, including binding postmortem brain tissue, neuroimaging, human laboratory models, analyses outcome data.Results-Findings indicate C allele rs2023239 is...
Loss of control is a prominent feature cannabis use disorders (CUD) and involves orchestrated activity from several brain inhibitory networks.In this study, we determined the associations between network activation connectivity CUD severity.To that end, compared cannabis-dependent (N = 44) vs. nondependent 30) users during Stop Signal Task. First, differences in neural response inhibition via general linear model analysis within priori regions interest. Second, examined functional...
Although there is emergent evidence illustrating neural sensitivity to cannabis cues in users, the specificity of this effect as opposed a generalized hyper-sensitivity hedonic stimuli has not yet been directly tested. Using fMRI, we presented 53 daily, long-term users and 68 non-using controls visual tactile for cannabis, natural reward, and, sensory-perceptual control object evaluate brain response users. The results showed an interaction between group reward type such that had greater...
As the most commonly used illicit substance during early adolescence, long-term or latent effects of adolescent marijuana use across developmental processes remain to be determined.We examined cortical thickness, gray/white matter border contrast (GWR) and local gyrification index (LGI) in 42 (MJ) users. Voxelwise regressions assessed early-onset (age <16) vs. late-onset (≥16 years-old) differences relationships continued while controlling for current age alcohol use.Although groups did not...
Background: Current work in motivational interviewing (MI) has supported the role of in-session client and therapist language predicting postintervention substance use outcomes. In particular, a relationship been found between specific (e.g., MI-consistent behaviors), types speech change talk; CT counterchange CCT), subsequent drinking One hypothesis to explain this phenomenon is that an indication neurocognitive shift happens during course psychosocial intervention. And, it possible...
Objective: The current study examined the relationship between severity of alcohol use disorders (AUDs) and neural circuits that underlie response inhibition error monitoring. In addition, we explored pre- post-inhibition trial processes to determine potential causal mechanisms responsible for disinhibition in AUDs. Method: One hundred sixty-four individuals with a range drinking from non-treatment-seeking adults problematic treatment-seeking dependence completed Go/NoGo task while...