A5060955934- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Alcoholism and Thiamine Deficiency
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Opioid Use Disorder Treatment
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Prenatal Substance Exposure Effects
- Attention Deficit Hyperactivity Disorder
- Neurological and metabolic disorders
- Cannabis and Cannabinoid Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Forensic Toxicology and Drug Analysis
- Advanced Neuroimaging Techniques and Applications
- Hormonal Regulation and Hypertension
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Smoking Behavior and Cessation
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Electroconvulsive Therapy Studies
University of Colorado Anschutz Medical Campus
2020-2025
The University of Texas Southwestern Medical Center
2012-2021
University of Colorado Denver
2019-2021
VA North Texas Health Care System
2012-2021
Southwestern Medical Center
2009-2020
University of Colorado System
2019
University of Florida
2017
Cooper Institute
2016
Dallas VA Medical Center
1996-2016
University of New Mexico
2016
This article presents the proceedings of a symposium held at meeting International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, October 2004. explored potential role hypothalamic-pituitary-adrenal (HPA) axis dysregulation upon relapse. HPA stimulation induces release glucocorticoid cortisol, compound with profound effects behavior and emotion. Altered stress-responses abstinent alcohol-dependent subjects, therefore, may influence their affective behavioral...
Frequent, purposeful exposure to ultraviolet (UV) light may induce a compulsive desire tan despite the negative consequences being known, suggesting behavioural complex similar addictive disorders.To assess presence of addictive-like behaviours in subjects using indoor tanning salons.Subjects (n = 100) were surveyed by two questionnaires: modified CAGE questionnaire consistent with problem and Diagnostic Statistical Manual Mental Disorders, 4th edition (DSM-IV) ('substance dependence'...
Background: Dysregulated striatal functioning coupled with executive control deficits arising from abnormal frontal cortical function are considered key mechanisms in the development and maintenance of cocaine addiction. The same features thought to underlie high trait impulsivity observed cocaine-addicted populations. Objectives: Employing resting state functional connectivity, current study sought identify cortico-striatal circuit alterations addiction examine degree which connectivity...
Excessive exposure to glucocorticoids can have neurotoxic effects. The behavioral, cognitive, and neurochemical changes observed following the cessation of heavy drinking, therefore, may be associated with disturbances hypothalamic-pituitary-adrenal (HPA) axis. To investigate HPA axis during ethanol withdrawal syndrome, authors examined diurnal in plasma cortisol six alcohol-dependent men abrupt discontinuation alcohol intake.Plasma concentrations were quantified every 30 minutes for 24...
Initial studies have indicated that stimulant abuse is prevalent among schizophrenic persons. To assess the phenomenon of cocaine by patients with schizophrenia, 17 male cocaine-abusing were compared 22 who did not use cocaine. The subjects had been hospitalized more frequently, likely to be paranoid subtype, and depressed at time interview. It appears may influence both psychopathologic presentation intensity care they require.
Background: Cortisol, the primary glucocorticoid in humans, is intimately involved regulation of such varied and critical biological processes as emotion, cognition, reward, immune functioning, energy utilization. A persistent increase cortisol concentration a result chronic intoxication could therefore alcohol‐related disorders sleep disruption, cognitive deficits, diabetes, mood disturbances. Although moderate levels acute alcohol ingestion are reported to produce an levels, it uncertain...
Opioid abuse is a national epidemic in the United States, where it estimated that prescription drug overdose death occurs every 19 minutes. While opioids are highly effective acute and subacute pain control, their use for treatment of chronic controversial. Chronic associated with tolerance, dependency, hyperalgesia. Although there new strategies practice guidelines to reduce opioid dependence overdose, has been little focus on development opioid-sparing therapeutic approaches. Lidocaine...
ABSTRACT Frequent and excessive tanning persists despite a growing understanding of its associated morbidity mortality, suggesting that ultraviolet radiation may impart rewarding effects beyond the assumed cosmetic benefits. To empirically measure putative centrally properties (UVR), we assessed commercially available bed upon regional cerebral blood flow (rCBF), brain activity, using single‐photon emission computed tomography (SPECT). Seven frequent salon tanners were placed under UVA/UVB...
Addiction to cocaine is a chronic condition characterized by high rates of early relapse. This study builds on efforts identify neural markers relapse risk studying resting state functional connectivity (rsFC) in circuits arising from the amygdala; brain region implicated relapse-related processes including craving and reactivity stress following acute protracted withdrawal cocaine. Whole-brain resting-state fMRI (6 min) was assessed 45 cocaine-addicted individuals 22 healthy controls....
While chronic cocaine use is associated with abnormalities in both brain structure and function within interactions between regions, previous studies have been limited to interrogating independently, the detected neural differences not applied independent samples assess clinical relevance of results. We investigated consequences structural on resting-state functional connectivity addiction tested whether identified circuits predict relapse an cohort. Subjects included 64...
Abstract Cocaine addiction is characterized by notoriously high relapse rates following treatment. Recent efforts to address poor treatment outcomes have turned potential neural markers of risk. Accordingly, the present study examined resting state functional connectivity (rsFC) within and between three large‐scale cortical networks: default mode network (DMN), salience (SN) executive control (ECN). All been implicated in relapse‐related phenomena including craving, withdrawal deficits....
Background: While English is only the native language of 7.3% world's population and less than 20% can speak language, nearly 75% all scientific publications are English. Aim: To describe how why contributions from non-English-speaking world have been excluded addiction literature, put forward suggestions for making this literature more accessible to population. Methods: A working group International Society Addiction Journal Editors (ISAJE) conducted an iterative review issues related...