A5103210339- Ion Transport and Channel Regulation
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Advanced Neuroimaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Electrolyte and hormonal disorders
- Insect and Arachnid Ecology and Behavior
- Epilepsy research and treatment
- Advanced Neural Network Applications
- Glioma Diagnosis and Treatment
- Insect Pheromone Research and Control
- Luminescence and Fluorescent Materials
- Radiomics and Machine Learning in Medical Imaging
- Magnesium in Health and Disease
- Lepidoptera: Biology and Taxonomy
- Tryptophan and brain disorders
- Medical Image Segmentation Techniques
- Diet and metabolism studies
- Advanced Nanomaterials in Catalysis
- Drug Transport and Resistance Mechanisms
- Image Retrieval and Classification Techniques
- Ion Channels and Receptors
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
Shaoguan University
2024-2025
West China Hospital of Sichuan University
2011-2024
Huazhong University of Science and Technology
2018-2024
Baotou Central Hospital
2012-2024
Sichuan University
2010-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chinese Academy of Agricultural Sciences
2018-2023
Institute of Pomology
2018-2023
Emory University
2011-2022
Central South University
2021
Most of what we know about antipsychotic drug effects is at the receptor level, distal from neural system that mediate their clinical efficacy. Studying cerebral function in antipsychotic-naive patients with schizophrenia before and after pharmacotherapy can enhance understanding therapeutic mechanisms these clinically effective treatments.To examine alterations regional network first-episode treatment second-generation medication.Case-control study.Huaxi MR Research Center Mental Health...
Root architecture is an important agronomic trait that plays essential role in water uptake, soil compactions, nutrient recycling, plant–microbe interactions, and hormone-mediated signaling pathways. Recently, significant advancements have been made understanding how the complex interactions of phytohormones regulate dynamic organization root crops. Moreover, phytohormones, particularly auxin, act as internal regulators development soil, starting from early organogenesis to formation hair...
Abstract Near‐infrared (NIR) chemiluminescence (CL) emission is highly favorable for deep‐tissue imaging, but chemically conjugated NIR CL emitters with the aggregation‐induced (AIE) property biotechnology are seldom reported. Herein, an AIE‐active emitter, TBL, synthesized by conjugating luminol unit electron‐accepting benzothiadiazole and electron‐donating triphenylamine, subsequently TBL dots prepared using F127 as surfactant. The of can last continuously over 60 min be employed...
An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared structures disorders. The aim this study was to assess gray matter volume (GMV) cortical thickness alterations non-comorbid medication-naive MDD patients SAD patients.High-resolution T1-weighted images were acquired from 37 patients, 24 41 healthy controls (HCs). Voxel-based morphometry...
Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These can release their cargo into adjacent or distant cells mediate intercellular communication cellular function. Here we examined the regulation of epithelial sodium channels in mpkCCD distal tubule Xenopus 2F3 by exosomes isolated from proximal LLC-PK1 cells. Cultured were stained with CTX coupled to a green fluorophore order label cell membranes freshly...
The rapid development of digital society and artificial intelligence has triggered explosive demands for specialty plastics, especially conjugated polymers that are instrumental flexible electronics smart devices. recycling degradation postconsumer have become more important than ever to reduce the pressure environment. Here we report discovery an environmentally self-degradable polymer poly(deca-4,6-diynedioic acid), or PDDA. PDDA is stable in dark without oxygen when used as a functional...
The success of Convolutional Neural Networks (CNNs) in 3D medical image segmentation relies on massive fully annotated volumes for training that are time-consuming and labor-intensive to acquire. In this paper, we propose annotate a target with only seven points images, design two-stage weakly supervised learning framework PA-Seg. the first stage, employ geodesic distance transform expand seed provide more supervision signal. To further deal unannotated regions during training, two...
Adapting a medical image segmentation model to new domain is important for improving its cross-domain transferability, and due the expensive annotation process, Unsupervised Domain Adaptation (UDA) appealing where only unlabeled images are needed adaptation. Existing UDA methods mainly based on or feature alignment with adversarial training regularization, they limited by insufficient supervision in target domain. In this paper, we propose an enhanced Filtered Pseudo Label (FPL+)-based...
Significance Statement The mineralocorticoid receptor within intercalated cells increases chloride transport in the mouse cortical collecting duct (CCD) through a mechanism involving apical chloride/bicarbonate exchanger pendrin. In studies, authors demonstrated that ablating this markedly changes pendrin’s total abundance and subcellular distribution direct effect of receptor, which occurs over wide range serum potassium concentration. also indirectly modulates sodium channel activity...
Recent functional magnetic resonance spectroscopy (fMRS) studies have shown changes in glutamate/glutamine (Glx) concentrations between resting-state and active-task conditions. However, the types of task used been limited to sensory paradigms, regions from which Glx measured ones. This leaves open question as whether same effect can be seen higher-order brain during cognitive tasks. Cortical midline structures, especially medial prefrontal cortex (MPFC), suggested involved various such We,...
A thin fluid layer in alveoli is normal and results from a balance of entry uptake by transepithelial salt water reabsorption. Conventional wisdom suggests the reabsorption via epithelial Na+ channels (ENaC), but if all were ENaC, then amiloride, an ENaC inhibitor, should block alveolar clearance (AFC). However, amiloride blocks only half AFC. The reason for failure to clear single-channel measurements cells: are observed, another channel present at same frequency that nonselective over K+,...
Amiloride-sensitive epithelial sodium channels (ENaC) are responsible for transepithelial Na(+) transport in the kidney, lung, and colon. The channel consists of three subunits (alpha, beta, gamma). In Madin-Darby canine kidney (MDCK) cells Xenopus laevis oocytes transfected with all ENaC subunits, neural precursor cell-expressed developmentally downregulated protein (Nedd4-2) promotes ubiquitin conjugation ENaC. For native proteins some cells, is a signal their degradation by...
Female sex predisposes individuals to poorer outcomes during respiratory disorders like cystic fibrosis and influenza-associated pneumonia. A common link between these is dysregulation of alveolar fluid clearance via disruption epithelial sodium channel (ENaC) activity. Recent evidence suggests that female hormones directly regulate expression activity ENaC. In our study, we identified the mechanism by which estradiol (E2) or progesterone (P4) independently regulates Using cell-attached...
The epithelial Na channel (ENaC) is negatively regulated by protein kinase C (PKC) as shown using PKC activators in a cell culture model. To determine whether PKCα influences ENaC activity vivo, we examined the regulation of renal tubules from −/− mice. Cortical collecting ducts were dissected and split open, exposed principal cells subjected to cell-attached patch clamp. In absence PKCα, open probability ( P o ) was increased three-fold vs. wild-type SV129 mice (0.52 ± 0.04 0.17 0.02)....
The present study explored whether the intercalated cell Cl(-)/HCO3(-) exchanger pendrin modulates epithelial Na(+) channel (ENaC) function by changing open probability and/or density. To do so, we measured ENaC subunit subcellular distribution immunohistochemistry, single recordings in split cortical collecting ducts (CCDs), as well transepithelial voltage and absorption CCDs from aldosterone-treated wild-type pendrin-null mice. Because gene ablation reduced 70-kDa more than 85-kDa γ-ENaC...
Abstract BACKGROUND The peach fruit moth, Carposina sasakii Matsumura (Lepidoptera: Carposinidae), is one of the most destructive pests pome and stone fruits, while few studies their molecular biology physiology have been conducted. Research into CsasPBPs ( pheromone binding proteins) CsasGOBPs general odorant may provide insights in to mechanisms olfaction . RESULTS In our study, results real time quantitative polymerase chain reaction (qPCR) assays demonstrated that CsasPBP1–3 CsasGOBP1–2...
Raman-based super multiplexing has attracted great interest in imaging, biological analysis, identity security, and information storage. It still remains a challenge to synthesize large number of different Raman-active molecules fulfill the Raman color palette. Here, we report facile systematic strategy construct continuously multiplexed ultrastrong probes. By precisely incorporating ratios 13C isotope into backbone poly(deca-4,6-diynedioic acid) (PDDA), can obtain library PDDAs with tunable...
Climate change poses a major threat to rice productivity, particularly due high-temperature stress during anthesis, which severely impacts the grain yield. Understanding physiological and biochemical responses of different genotypes is critical for breeding resilient varieties. In this study, we assessed two contrasting genotypes, high-temperature-tolerant-1 (HTR-1) high-temperature-sensitive (HTS-5), confirm previously established hormonal mechanisms associated with tolerance. The study...
Background: Epilepsy is a common symptom in patients with diffuse lower‐grade glioma (DLGG). However, the specific role of cortical alterations glioma‐related epilepsy (GRE) remains unclear. This study aimed at investigating reorganization architecture and network changes associated GRE. Materials Methods: High‐resolution T1‐weighted T2‐weighted images were acquired from DLGG (GRE = 68, non‐GRE 79) 94 healthy controls (HCs). Cortical thickness myelin content calculated using Human Connectome...