A5005142506- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Child and Adolescent Psychosocial and Emotional Development
- Diet, Metabolism, and Disease
- HIV-related health complications and treatments
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- HIV Research and Treatment
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Posttraumatic Stress Disorder Research
- Regulation of Appetite and Obesity
- HIV/AIDS Research and Interventions
- Neurotransmitter Receptor Influence on Behavior
- Child Abuse and Trauma
- Memory and Neural Mechanisms
- Intensive Care Unit Cognitive Disorders
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
Virginia Commonwealth University
2016-2025
Children's Hospital of Richmond at VCU
2023
University of Richmond
2023
Georgetown University
2022
Johns Hopkins University
2022
Albert Einstein College of Medicine
2022
University of Illinois Chicago
2022
Emory University
2011-2021
Icahn School of Medicine at Mount Sinai
2021
University of California, San Diego
2021
Notable sex-differences exist between neural structures that regulate sexually dimorphic behaviors such as reproduction and parenting. While anatomical differences have been well-characterized, advancements in neuroimaging pharmacology techniques allowed researchers to identify males females down the level of synapse. Disparate mechanisms at synaptic contribute sex-specific neuroplasticity is reflected sex-dependent behaviors. Many these are driven by endocrine system its impact on molecular...
Aim To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function sociodemographic characteristics. Methods Cross-sectional metrics puberty were utilized from the baseline assessment Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample 9–10 year-olds (n = 11,875)—and included via development scale (PDS) child salivary hormone levels (dehydroepiandrosterone testosterone all, estradiol...
The Adolescent Brain Cognitive Development (ABCD) Study of 11,880 youth incorporates a comprehensive range measures assessing predictors and outcomes related to mental health across childhood adolescence in participating youth, as well information about family history. We have previously described the logic content assessment battery at Baseline 1-year follow-up. Here, we describe changes that issues clarifications emerged, additions 2-, 3-, 4-, 5-year follow-ups. capitalize on recent...
Abstract Background There is ample evidence that psychological stress adversely affects many diseases. Recent has shown intense stressors can increase inflammation within the brain, a known mediator of However, long-term outcomes chronic elicit neuroinflammatory response remain unknown. Methods To address this, we have modified previously described models rat/mouse predatory (PS) to intensity interaction. We postulated these modifications would enhance predator-prey experience and...
Synaptic plasticity is the ability of synapses to modulate strength neuronal connections; however, molecular factors that regulate this feature are incompletely understood. Here, we demonstrated mice lacking brain-specific angiogenesis inhibitor 1 (BAI1) have severe deficits in hippocampus-dependent spatial learning and memory accompanied by enhanced long-term potentiation (LTP), impaired depression (LTD), a thinning postsynaptic density (PSD) at hippocampal synapses. We showed compared with...
NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation improve outcome in rodent models of cerebral ischemia. However, the impact chronic stress on NLRP3 autophagic response to ischemia remains unknown. Progesterone (PROG), a neuroprotective steroid, shows promise reducing excessive associated with poor ischemic brain injury patients comorbid conditions, including elevated stress. Stress primes microglia, mainly by release...