A5008545020- Peroxisome Proliferator-Activated Receptors
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Heart Rate Variability and Autonomic Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Inflammatory mediators and NSAID effects
- Neurogenesis and neuroplasticity mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Retinal Development and Disorders
- Nerve injury and regeneration
- Eicosanoids and Hypertension Pharmacology
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vitamin D Research Studies
- Cell Adhesion Molecules Research
- Cardiac Arrest and Resuscitation
- Stress Responses and Cortisol
Institute of Cytology and Genetics
2019-2022
Boston Children's Hospital
2019-2021
Harvard University
2019-2021
First Pavlov State Medical University of St. Petersburg
2009-2021
Emory University
2016-2020
Siberian Branch of the Russian Academy of Sciences
2019
Vitebsk State Medical University
2018
Otto-von-Guericke University Magdeburg
2012-2017
Center for Behavioral Brain Sciences
2017
Federal Almazov North-West Medical Research Centre
2014
Purpose.: Little is known about the physiological mechanisms underlying reported therapeutic effects of transorbital alternating current stimulation (ACS) in vision restoration, or origin recorded electrically evoked potentials (EEPs) during such stimulation. We examined issue EEP and electrode configuration for ACS characterized responses to CS different structures visual system. Methods.: visually (VEPs) EEPs from rat retina, thalamus, tectum, cortex. The VEPs were by light flashes...
Abstract We examined the effect of progesterone treatments on glycolytic metabolism and senescence as possible mechanisms in controlling growth glioblastoma multiforme (GBM). In an orthotopic mouse model, after tumor establishment, athymic nude mice received treatment with or vehicle for 40 days. Compared to controls, high-dose administration produced a significant reduction size (~47%) increased survival rate (~43%) without any demonstrable toxicity peripheral organs (liver, kidney). This...
Noninvasive alternating current stimulation can induce vision restoration in patients with chronic optic nerve damage and results electroencephalogram (EEG) aftereffects. To better understand the mechanisms of action, we studied such EEG "aftereffects" transcorneal (tACS) at posttraumatic state rats. baseline was recorded from visual cortex under ketamine/xylazine narcosis healthy rats severe crush. One week later, both groups were again anesthetized stimulated transcorneally twice for 12...
Repetitive transorbital alternating current stimulation (rtACS) improves vision in patients with chronic visual impairments and an acute treatment increased survival of retinal neurons after optic nerve crush (ONC) rodent models system injury. However, despite this protection no functional recovery could be detected rats, which was interpreted as evidence "silent survivor" cells. We now analysed the mechanisms underlying survival" effect. Using vivo microscopy retina we investigated...
Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention neuronal plasticity, we explored whether potentiation of the cholinergic transmission has effect on function restoration. To this end, evaluated for 4 weeks acetylcholinesterase inhibitor donepezil brightness discrimination, visually evoked potentials, cortex reactivity after bilateral partial optic nerve crush adult rats....
Transcorneal alternating current stimulation (tACS) has become a promising tool to modulate brain functions and treat visual diseases. To understand the mechanisms of action suitable animal model is required. However, because existing models employ narcosis, which interferes with oscillations effects, we developed an experimental setup where via eye flicker light can be applied while simultaneously recording local field potentials in awake rats.tACS was freely-moving rats (N = 24) had wires...
Introduction: Stress is associated with increased risk of stroke and poor prognosis, but the mechanisms through which stress may alter outcome remain elusive. compromises neuronal survival neuroinflammation following an ischemic attack. Post-ischemic inflammatory response involves activation microglia, can be polarized from a harmful M1 phenotype expresses pro-inflammatory cytokines, to protective M2 releases neurotrophic factors. We hypothesize that progesterone (PROG) will improve global...
GENERAL COMMENTARY article Front. Hum. Neurosci., 05 November 2014Sec. Brain Imaging and Stimulation https://doi.org/10.3389/fnhum.2014.00899
Aim. To reveal the molecular genetic predictors of adverse clinical course coronary heart disease (CHD). Material and methods. A investigation performed, 567 CHD patients, those 199 underwent dynamic follow-up. Genotypes Pro12Pro, Pro12Ala, Ala12Ala gene PPAR- γ 2 , genotypes L162L L162V α A603A, A603G, G603G tissue factor were assessed with polymerase chain reaction further restrictional analysis. Results. Carriage allele V162 Ala12 is associated development following endpoints in patients:...
Coronary artery disease (CAD) remains the leading cause of death and disability in developed countries. Using traditional risk factors for CAD, it is possible to predict likelihood acute coronary events no more than 50% cases. Therefore, study influence genetic epigenetic on development CAD extremely important. Research recent years has shown that vitamin D deficiency a new factor atherosclerosis immune inflammation. Vitamin implements protective effects against inflammation through...
There is growing evidence that the TIR-domain-containing adapter-inducing interferon-β (TRIF) pathway implicated in modulation of neuroinflammation following injuries to brain and retina. After exposure injury or excitotoxic pathogens, toll-like receptors (TLR) activate innate immune system signaling cascade stimulate release inflammatory cytokines. Inhibition TLR4 receptor has been shown enhance retinal ganglion cell (RGC) survival optic nerve crush (ONC) ischemic other parts brain.Based on...
New risk factors for coronary artery disease (CAD) have been identified recently – mediators of immune inflammation. Peroxisome proliferator-activated receptors alpha (PPAR-α) belong to nuclear superfamily and regulate the activity different genes coding The goal this study is determine association L162V polymorphism PPAR-α gene with inflammation development in Russian population. current included 424 patients (359 men 65 women) aged 33 80 years (mean age- 61,6 ± 0,48 years). control group...