Jens Treutlein
A5088638402- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Genetic Syndromes and Imprinting
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Substance Abuse Treatment and Outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Peroxisome Proliferator-Activated Receptors
- Plant Diversity and Evolution
- Functional Brain Connectivity Studies
- Cognitive Abilities and Testing
- Hormonal Regulation and Hypertension
- Adolescent and Pediatric Healthcare
- Autism Spectrum Disorder Research
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Health, Environment, Cognitive Aging
Heidelberg University
2016-2025
University Hospital Heidelberg
2014-2024
Central Institute of Mental Health
2012-2024
Massachusetts General Hospital
2019
University Medical Center
2019
Life & Brain (Germany)
2011-2018
University of Bonn
2011-2018
SUNY Upstate Medical University
2018
Southwest Jiaotong University
2018
Shanghai Jiao Tong University
2018
<h3>Context</h3> Alcohol dependence is a serious and common public health problem. It well established that genetic factors play major role in the development of this disorder. Identification genes contribute to alcohol will improve our understanding mechanisms underlie <h3>Objective</h3> To identify susceptibility for through genome-wide association study (GWAS) follow-up population German male inpatients with an early age at onset. <h3>Design</h3> The GWAS tested 524 396 single-nucleotide...
Salvia, with over 900 species from both the Old and New World, is largest genus in Lamiaceae. Unlike most members of subfamily Nepetoideae to which it belongs, only two stamens are expressed Salvia. Although structure these remarkably variable across genus, generally each stamen has an elongate connective divergent anther thecae, form a lever mechanism important pollination. In preliminary investigation infrageneric relationships within monophyly its relationship other tribe Mentheae were...
Abstract Borderline personality disorder (BOR) is determined by environmental and genetic factors, characterized affective instability impulsivity, diagnostic symptoms also observed in manic phases of bipolar (BIP). Up to 20% BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) BOR, performed one largest BOR patient samples worldwide. The focus our analysis was (i) detect genes gene sets involved (ii) investigate overlap...
Multiple lines of evidence suggest that the circadian clock contributes to pathogenesis winter depression or seasonal affective disorder (SAD). We hypothesized sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at core clock, predispose depression.In silico analysis biological effects allelic differences suggested target single-nucleotide polymorphisms (SNPs) be analyzed sample 189 patients matched controls. The most relevant SNP each gene was...
ABSTRACT Alcohol dependence (AD) is an important contributory factor to the global burden of disease. The etiology AD involves both environmental and genetic factors, disorder has a heritability around 50%. aim present study was identify susceptibility genes for by performing genome‐wide association (GWAS). sample comprised 1333 male in‐patients with severe according Diagnostic Statistical Manual Mental Disorders, 4th edition, 2168 controls. These included 487 patients 1358 controls from...
Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an risk factor for abuse. rhythm gene period 1 (Per1) targeted by hormones transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized Per1 involved integrating response circadian rhythmicity explored its relevance to drinking.In mice, the effects of on ethanol intake mPer1-mutant wild-type mice were assessed. In humans, single...
Previous research examining gene–environment interaction (G×E) with regard to vulnerability depression and anxiety has yielded conflicting results. The present study was designed further investigate G×E between 5-HTTLPR exposure environmental adversity, using different phenotypic genotypic characterizations as well types of adversity within a prospective design. Data were available from an ongoing epidemiological cohort following the outcome early risk factors birth adulthood. At age 19 yr,...
<h3>Context</h3> Glutamatergic neurotransmission is implicated in alcohol-drinking behavior animal models. <h3>Objective</h3> To investigate whether genetic variations glutamatergic genes, which are known to alter alcohol effects rodents, contribute the basis of alcoholism humans. <h3>Design</h3> Association analysis dependence and haplotype-tagging single nucleotide polymorphisms (SNPs) covering 10 genes. Resequencing functional domains these genes identified 204 SNPs. Haplotypes with a...
Research in animals and first results adolescents have indicated that genetic variation the corticotropin-releasing hormone receptor 1 (CRHR1) is associated with heavy alcohol consumption related to stress. The purpose of this study was determine whether two haplotype-tagging single nucleotide polymorphisms covering CRHR1 gene (rs242938, rs1876831) interact stressful life events affecting age at drinking initiation young adults. Participants were drawn from Mannheim Study Children Risk, an...
We have previously shown that urban upbringing and city living were associated with stress-induced activity in the amygdala perigenual anterior cingulate cortex (pACC). This finding might link epidemiological risk factor "urbanicity" to neurobiological mechanisms of psychiatric disorders. However, given heritability stress-related phenotypes, it appears likely genetic factors can modulate effect urbanicity on social stress processing. In present exploratory study, we investigated if a...
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological remain largely unknown. A recent SCZ genome wide association study (GWAS) the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). present...
Abstract Major depressive disorder (MDD) is a common, complex psychiatric and leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity genetic architecture have complicated efforts to detect associated risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE PGC MDD, representing 10 502 Chinese (5282 cases 5220 controls) 18 663 European (9447 9215 subjects. determined fraction...
Abstract Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric with lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, class small noncoding RNAs, contribute to basic mechanisms underlying brain development plasticity, suggesting their possible involvement in pathogenesis several psychiatric disorders, including BD. In present...