Dan Rujescu
A5043595820- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Genomic variations and chromosomal abnormalities
- Bipolar Disorder and Treatment
- Genomics and Rare Diseases
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Suicide and Self-Harm Studies
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- Congenital heart defects research
- Mental Health Research Topics
- Bioinformatics and Genomic Networks
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Health, Environment, Cognitive Aging
- Personality Disorders and Psychopathology
- Stress Responses and Cortisol
Martin Luther University Halle-Wittenberg
2016-2025
Medical University of Vienna
2011-2025
Comprehensive Cancer Center Vienna
2023-2025
Ludwig-Maximilians-Universität München
2013-2023
Molecular Biology Consortium
2023
Hertie Institute for Clinical Brain Research
2021-2023
German Center for Neurodegenerative Diseases
2021-2023
University of Tübingen
2021-2023
Quaid-i-Azam University
2023
University of Vienna
2022-2023
Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified first strongly supported LOAD susceptibility genes since discovery involvement APOE in early 1990s. We have now exploited these GWAS datasets to uncover key pathophysiological processes. Methodology applied a recently developed tool for mining data biologically meaningful information dataset. The principal findings were then tested an independent...
Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families schizophrenia. We examined NRXN1, closely related NRXN2 NRXN3 genes, for copy number variants (CNVs) 2977 schizophrenia patients 33 746 controls from seven European populations (Iceland, Finland, Norway, Germany, The Netherlands, Italy UK) using microarray data. found 66 deletions 5 duplications including a de novo deletion: 12 2 occurred cases (0.47%) compared to 49 3...
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) in schizophrenia. investigated SNPs using 871 patients 863 controls, following up the top hits four independent cohorts comprising 1,460 12,995 all European origin. found no significant associations, nor could we provide support for any previously reported candidate gene or associations. went on to examine CNVs subset 1,013 cases 1,084 controls ancestry, further set 60 64 African...
Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more "missing heritability" common complex phenotypes. However, reliable methods identify a larger proportion single nucleotide polymorphisms (SNPs) impact disease risk are currently lacking. Here, we use genetic pleiotropy-informed conditional false discovery rate (FDR) method on GWAS summary statistics data new loci associated with schizophrenia (SCZ) and bipolar disorders (BD), two...
Suicide is a major public health problem in the WHO European Region accounting for over 150,000 deaths per year. SUICIDAL CRISIS: Acute intervention should start immediately order to keep patient alive.An underlying psychiatric disorder present up 90% of people who completed suicide. Comorbidity with depression, anxiety, substance abuse and personality disorders high. In achieve successful prevention suicidality, adequate diagnostic procedures appropriate treatment are essential.Existing...
Despite significant research efforts aimed at understanding the neurobiological underpinnings of psychiatric disorders, diagnosis and evaluation treatment these disorders are still based solely on relatively subjective assessment symptoms. Therefore, biological markers which could improve current classification psychiatry in perspective stratify patients a basis into more homogeneous clinically distinct subgroups, highly needed. In order to identify novel candidate for major depression...