Martin Begemann
A5059455072- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Glioma Diagnosis and Treatment
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Brain Metastases and Treatment
- Autoimmune Neurological Disorders and Treatments
- Polyomavirus and related diseases
- Erythropoietin and Anemia Treatment
- Cancer-related Molecular Pathways
- Pharmacological Effects and Toxicity Studies
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Autism Spectrum Disorder Research
- Respiratory viral infections research
- Diet and metabolism studies
- Microtubule and mitosis dynamics
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Ion channel regulation and function
- Genetic Syndromes and Imprinting
Max Planck Institute of Experimental Medicine
2013-2024
University of Göttingen
2017-2024
Max Planck Institute for Multidisciplinary Sciences
2022-2024
Universitätsmedizin Göttingen
2020-2021
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2013-2019
Deutsche Forschungsgemeinschaft
2019
Max Planck Society
2004-2015
Max Planck Innovation
2014
Max Planck Institute for Molecular Genetics
2005-2006
Memorial Sloan Kettering Cancer Center
2002-2005
We previously reported an unexpectedly high seroprevalence (~10%) of N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1) autoantibodies (AB) in healthy and neuropsychiatrically ill subjects (N = 2,817). This finding challenges unambiguous causal relationship serum AB with brain disease. To test whether similar results would be obtained for other antigen-directed connected pathological conditions, we systematically screened samples 4,236 individuals.Serum (n 1,703) versus (schizophrenia,...
Autoantibodies of the IgG class against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB) were considered pathognomonic for anti-NMDAR encephalitis. This view has been challenged by age-dependent seroprevalence (up to >20%) functional NMDAR1-AB all immunoglobulin classes found in >5000 individuals, healthy or affected different diseases. These findings question a merely encephalitogenic role NMDAR1-AB. Here, we show that belong normal autoimmune repertoire dogs, cats, rats, mice,...
Context: Schizophrenia is the collective term for a heterogeneous group of mental disorders with still obscure biological basis.In particular, specific contribution risk or candidate gene variants to complex schizophrenic phenotype largely unknown.Objective: To prepare ground novel "phenomics" approach, unique schizophrenia patient database was established by GRAS (Göttingen Research Association Schizophrenia), designed allow association genetic information quantifiable phenotypes.Because...
Behavioral phenotypical continua from health to disease suggest common underlying mechanisms with quantitative rather than qualitative differences. Until recently, autism spectrum disorders and schizophrenia were considered distinct nosologic entities. However, emerging evidence contributes the blurring of symptomatic genetic boundaries between these conditions. The present study aimed at quantifying behavioral phenotypes shared by prepare ground for biological pathway analyses.Specific...
The magnitude of the human antibody response to viral antigens is highly variable. To explore genetic contribution this variability, we performed genome-wide association studies immunoglobulin G 14 pathogenic viruses in 2,363 immunocompetent adults. Significant associations were observed major histocompatibility complex region on chromosome 6 for influenza A virus, Epstein-Barr JC polyomavirus, and Merkel cell polyomavirus. Using local imputation fine mapping, identified specific amino acid...
Circulating autoantibodies (AB) against brain-antigens, often deemed pathological, receive increasing attention. We assessed predispositions and seroprevalence/characteristics of 49 AB in > 7000 individuals.Exploratory cross-sectional cohort study, investigating deeply phenotyped neuropsychiatric patients healthy individuals GRAS Data Collection for presence/characteristics brain-directed serum-AB. Predispositions were evaluated through GWAS NMDAR1-AB carriers, analyses immune check-point...
Abstract Background Schizophrenia is the collective term for an exclusively clinically diagnosed, heterogeneous group of mental disorders with still obscure biological roots. Based on assumption that valuable information about relevant genetic and environmental disease mechanisms can be obtained by association studies patient cohorts ≥ 1000 patients, if performed detailed clinical datasets quantifiable readouts, we generated a new schizophrenia data base, GRAS (Göttingen Research Association...
Claustrophobia, the well-known fear of being trapped in narrow/closed spaces, is often considered a conditioned response to traumatic experience. Surprisingly, we found that mutations affecting single gene, encoding stress-regulated neuronal protein, can cause claustrophobia. Gpm6a-deficient mice develop normally and lack obvious behavioral abnormalities. However, when mildly stressed by single-housing, these striking claustrophobia-like phenotype, which not inducible wild-type controls,...
Abstract Ambra1 is linked to autophagy and neurodevelopment. Heterozygous deficiency induces autism-like behavior in a sexually dimorphic manner. Extraordinarily, autistic features are seen female mice only, combined with stronger protein reduction brain compared males. However, significance of AMBRA1 for phenotypes humans and, apart from behavior, other autism-typical features, namely early enlargement or increased seizure propensity, has remained unexplored. Here we show two independent...
Abstract Hypoxia is more and perceived as pivotal physiological driving force, allowing cells in the brain elsewhere to acclimate lowered oxygen (O 2 ), abridged metabolism. The mediating transcription program induced by inspiratory hypoxia but also intensive motor‐cognitive tasks, provoking a relative decrease O relation acutely augmented requirement. We termed this fundamental, demand‐dependent drop availability “functional hypoxia.” Major players response are hypoxia‐inducible factors...