A5008696464- Neurogenesis and neuroplasticity mechanisms
- Connexins and lens biology
- Heat shock proteins research
- Advanced Neuroimaging Techniques and Applications
- Cellular transport and secretion
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Axon Guidance and Neuronal Signaling
- Tryptophan and brain disorders
- Infectious Encephalopathies and Encephalitis
- EEG and Brain-Computer Interfaces
- Neurological diseases and metabolism
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Bipolar Disorder and Treatment
- Hereditary Neurological Disorders
- Cardiac Arrest and Resuscitation
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Galectins and Cancer Biology
- Advanced MRI Techniques and Applications
- Pancreatic function and diabetes
- Nerve injury and regeneration
Max Planck Institute for Multidisciplinary Sciences
2023
Max Planck Institute of Experimental Medicine
2012-2019
Max Planck Society
2012-2013
Subtle white matter abnormalities have emerged as a hallmark of brain alterations in magnetic resonance imaging or upon autopsy mentally ill subjects. However, it is unknown whether such reduction and myelin contributes to any disease‐relevant phenotype simply constitutes an epiphenomenon, possibly even treatment‐related. Here, we re‐analyzed Mbp heterozygous mice, the unaffected parental strain shiverer , classical neurological mutant. Between 2 20 months age, +/‐ versus +/+ littermates...
Abstract The cerebellar cortex is involved in the control of diverse motor and non-motor functions. Its principal circuit elements are Purkinje cells that integrate incoming excitatory local inhibitory inputs provide sole output cortex. However, transcriptional assembly not well understood. Here, we show NeuroD2, a neuronal basic helix-loop-helix (bHLH) transcription factor, promotes postnatal survival both granule molecular layer interneurons (basket stellate cells). while NeuroD2 essential...
Nedd4-2 is an E3 ubiquitin ligase in which missense mutation related to familial epilepsy, indicating its critical role regulating neuronal network activity. However, substrates involved function have yet be identified. Using mouse lines lacking Nedd4-1 and Nedd4-2, we identified astrocytic channel proteins inwardly rectifying K+ 4.1 (Kir4.1) Connexin43 as substrates. We found that the expression of Kir4.1 increased upon conditional deletion astrocytes, leading elevation membrane ion...
Oligodendrocytes make myelin for rapid impulse propagation and contribute to the long‐term survival of myelinated axons. The mechanisms by which oligodendroglial dysfunction(s) slowly progressive neurodegeneration are not well understood. Here, we demonstrate in Cnp1 mutant mice that secondary axonal degeneration subcortical white matter is associated with an age‐dependent activation both, innate adaptive immune responses, including expansion infiltrating CD8+ T cells. While detrimental role...
ABSTRACT Nedd4-2 is an E3 ubiquitin ligase, missense mutation of which related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, substrates involved function have yet be identified. Using mouse lines lacking Nedd4-1 and Nedd4-2, we identified astrocytic channel proteins inwardly rectifying K + 4.1 (Kir4.1) Connexin43 as substrates. We found that the expression Kir4.1 increased upon conditional deletion astrocytes, leading elevation membrane...