A5112015334- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Neonatal Respiratory Health Research
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Neonatal and fetal brain pathology
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Congenital Diaphragmatic Hernia Studies
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Respiratory Support and Mechanisms
- Electroconvulsive Therapy Studies
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Mental Health and Psychiatry
- Treatment of Major Depression
- Infant Development and Preterm Care
- Obsessive-Compulsive Spectrum Disorders
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
Hofstra University
2016-2025
Hudson Institute of Medical Research
2016-2025
Monash Children’s Hospital
2016-2025
Feinstein Institute for Medical Research
2016-2025
Zucker Hillside Hospital
2016-2025
Northwell Health
2016-2025
Monash University
2016-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2018-2025
Monash Health
2013-2025
University of California, San Diego
2015-2025
A major line of evidence that supports the hypothesis dopamine overactivity in schizophrenia is psychomimetic potential agents such as amphetamine stimulate outflow. novel brain imaging method provides an indirect measure vivo synaptic concentration by quantifying change receptor radiotracer binding produced alter release but do not themselves bind to receptors. The purpose this investigation ( i ) determine sensitivity (i.e., amount reflected changes) examining relationship between...
OBJECTIVE: In the prefrontal cortex, enzyme catechol O-methyltransferase (COMT) is critical in metabolic degradation of dopamine, a neurotransmitter hypothesized to influence human cognitive function. The COMT gene contains functional polymorphism, Val158Met, that exerts fourfold effect on activity. current study investigated whether cognition varies with genotype. METHOD: Val158Met was genotyped 73 healthy volunteers. A task cognition, Wisconsin Card Sorting Test, also administered....
<h3>Context</h3> Cognitive impairment in schizophrenia is frequent, involves multiple domains, and enduring. Numerous recent clinical trials have suggested that second-generation antipsychotic medications significantly enhance cognition schizophrenia. However, none of these studies included healthy controls undergoing repeated testing to assess the possibility improvements might reflect simple practice effects. <h3>Objective</h3> To report results on a randomized comparison 2 widely...
Agents that antagonize the N-methyl-D-aspartic acid (NMDA) receptor, such as phencyclidine and ketamine, produce an acute psychotic state in normal individuals resembles some symptoms of schizophrenia. The aim this study was to determine which brain regions are involved NMDA receptor-mediated psychosis.Positron emission tomography with [18F]fluorodeoxyglucose used cerebral metabolic activity 17 healthy volunteers while induced simultaneously by administration subanesthetic doses...
Evolutionarily significant selective sweeps may result in long stretches of homozygous polymorphisms individuals from outbred populations. We developed whole-genome homozygosity association (WGHA) methodology to characterize this phenomenon healthy and use genomic feature identify genetic risk loci for schizophrenia (SCZ). Applying WGHA 178 SCZ cases 144 controls genotyped at 500,000 markers, we found that runs (ROHs), ranging size 200 kb 15 mb, were common unrelated Caucasians. Properties...
Up to 70% of patients with treatment-resistant schizophrenia do not respond clozapine. Pharmacological augmentation clozapine has been studied unimpressive results. The authors examined the use ECT as an for treatment-refractory schizophrenia.In a randomized single-blind 8-week study, clozapine-resistant were assigned treatment usual (clozapine group) or course bilateral plus (ECT group). Nonresponders from group received open trial (crossover phase). was performed three times per week first...
Background Recent data suggest trait-like neurocognitive impairments in bipolar disorder (BPD), with deficits about 1 s .d. below average, less severe than noted schizophrenia. The frequency of significant impairment BPD is approximately 60%, 40% patients characterized as cognitively spared. This contrasts a more homogeneous presentation It not understood why some develop while others do not. Method A total 136 completed the MATRICS Consensus Cognitive Battery and were entered into...
Previous evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although striatum is primary target all efficacious antipsychotics, relationship between its functional connectivity and symptomatic reduction remains unknown.To explore longitudinal effect treatment with second-generation antipsychotics on during resting state patients experiencing a first episode psychosis.This prospective controlled study took place at clinical research center included 24...
Treatment with nasal high-flow therapy has efficacy similar to that of continuous positive airway pressure (CPAP) when used as postextubation support in neonates. The the primary means respiratory for preterm infants distress not been proved.
Clinical response to antipsychotic drug treatment is highly variable, yet prognostic biomarkers are lacking. The authors recently demonstrated that successful alters resting-state functional connectivity of the striatum. goal present study was test whether intrinsic striatal patterns provide information and can serve as a potential biomarker drugs.The used MRI (fMRI) develop index in discovery cohort 41 first-episode schizophrenia patients, then tested this an independent 40 newly...