A5100664892- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Cardiovascular Disease and Adiposity
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Acute Ischemic Stroke Management
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Luminescence and Fluorescent Materials
- Cervical Cancer and HPV Research
- Reproductive Biology and Fertility
- Photochromic and Fluorescence Chemistry
- Glaucoma and retinal disorders
- Photoreceptor and optogenetics research
- Plant tissue culture and regeneration
- Stress Responses and Cortisol
- Mechanisms of cancer metastasis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomic variations and chromosomal abnormalities
- Peripheral Neuropathies and Disorders
- Virus-based gene therapy research
Harbin Medical University
2023-2025
Fourth Affiliated Hospital of Harbin Medical University
2023-2025
Huazhong University of Science and Technology
2004-2024
Peking University
2020-2024
Leibniz Institute for Immunotherapy
2022-2024
Peking University First Hospital
2020-2024
Wenzhou Medical University
2018-2024
Zunyi Medical University
2022-2024
Wuhan National Laboratory for Optoelectronics
2023
Shandong Provincial Hospital
2023
Autoantibodies of the IgG class against N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1) were first described in anti-NMDAR encephalitis and seen as disease indicators. Recent work on together over 5000 individuals challenged this exclusive view by showing age-dependently up to >20% NMDAR1-autoantibody seroprevalence with comparable immunoglobulin titer distribution across health disease. The key question therefore is understand properties these autoantibodies, also healthy carriers, order...
The underlying cellular mechanisms of catatonia, an executive "psychomotor" syndrome that is observed across neuropsychiatric diseases, have remained obscure. In humans and mice, reduced expression the structural myelin protein CNP associated with catatonic signs in age-dependent manner, pointing to involvement myelin-producing oligodendrocytes. Here, we showed cause low-grade inflammation white matter tracts, which marks a final common pathway Cnp-deficient other mutant mice minor...
Autoantibodies of the IgG class against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB) were considered pathognomonic for anti-NMDAR encephalitis. This view has been challenged by age-dependent seroprevalence (up to >20%) functional NMDAR1-AB all immunoglobulin classes found in >5000 individuals, healthy or affected different diseases. These findings question a merely encephalitogenic role NMDAR1-AB. Here, we show that belong normal autoimmune repertoire dogs, cats, rats, mice,...
Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range definition of CPB-associated AKI discuss possible impact different disease recognition methods on research outcomes. Furthermore, introduce specialized equipment procedural intricacies CPB surgeries. Based recent research, potential pathogenesis that may result from CPB, including...
Abstract STUDY QUESTION Is a dual ovulation trigger with combination of GnRH agonist (GnRHa) and hCG superior to single and/or GnRHa in improving treatment outcomes advanced-age women (aged ≥ 35 years) undergoing IVF/ICSI treatment? SUMMARY ANSWER Co-administration as increases the number good-quality embryos but it is not associated higher oocytes retrieved, compared or trigger. WHAT IS KNOWN ALREADY Many studies have demonstrated that has positive impact on oocyte maturation, retrieval...
Abstract Diarylethene molecular photoswitches hold great fascination as optical information materials due to their unique bistability and exceptional reversible photoswitching properties. Conventional diarylethenes, however, rely on UV light for ring‐closure reactions, typically with modest yields. For practical application, diarylethenes driven by visible lights are preferred but achieving high reaction yield remains a significant challenge. Herein, we synthesized novel...
A visible-light driven solid-state NIR fluorescent bistable molecular switch was constructed by coupling bulky tetraphenylethylene, photochromic diarylethene and emissive terrylene diimide. Multi-level optical storage demonstrated based on its film.
Abstract Cubitus varus deformity is the most common late complication of malunited supracondylar fracture that requires corrective osteotomy and fixation. From 2009 to 2017, 40 consecutive patients with cubitus were included. Twenty underwent conventional closing-wedge (conventional group), while other twenty 3D-printed model template (3D-printed group). The functional outcome was evaluated using Mayo Elbow Performance Index (MEPI) Score Flynn criteria. There no statistically significant...
Circulating autoantibodies (AB) of different immunoglobulin classes (IgM, IgA, and IgG), directed against the obligatory N-methyl-D-aspartate-receptor subunit NR1 (NMDAR1-AB), belong to mammalian autoimmune repertoire, appear with age-dependently high seroprevalence across health disease. Upon access brain, they can exert NMDAR-antagonistic/ketamine-like actions. Still unanswered key questions, addressed here, are conditions NMDAR1-AB formation/boosting, intraindividual persistence/course in...
This cross-sectional epidemiological study aimed to investigate awareness regarding human papillomavirus (HPV) and willingness for vaccination among college students with or without medical background in Guizhou Province, China. A logistic regression model was used univariate multivariate analyses of cognition determine factors influencing vaccination. In total, 2,540 questionnaires were collected, which 2,360 valid. The nonmedical groups included 737 (31.2%) 1,623 (68.8%) individuals,...
Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine postsynaptic receptors located at neuromuscular junction. "Warming yang and invigorating qi" acupuncture treatment has reduce serum inflammatory cytokine expression increase transforming growth factor beta rats with experimental myasthenia gravis. However, few studies addressed effects of this type on Here, we used confocal laser scanning microscopy examine area density...
Pericoronary adipose tissue (PCAT) around the proximal right coronary artery (RCA) is considered a marker of inflammation. We aimed to explore segments PCAT that represent inflammation in patients with acute syndrome (ACS) and identify ACS stable disease (CAD) prior intervention.We retrospectively enrolled consecutive CAD who underwent invasive angiography (ICA) after computed tomography (CCTA) from November 2020 October 2021 at Fourth Affiliated Hospital Harbin Medical University. The fat...
Abstract Encephalitis has an estimated prevalence of ≤0.01%. Even with extensive diagnostic work-up, infectious etiology is identified or suspected in <50% cases, suggesting a role for etiologically unclear, noninfectious processes. Mild encephalitis runs frequently unnoticed, despite slight neuroinflammation detectable postmortem many neuropsychiatric illnesses. A widely unexplored field humans, though clearly documented rodents, genetic brain inflammation, particularly that associated...
Abstract Background The differences in fat deposition sites exhibit varying degrees of systemic inflammatory responses and organ damage, especially obese individuals with excessive visceral fat. Visceral fat, which is closely related to an increase mortality rates heart liver diseases. However, few studies have analysed the indicators their correlation among groups based on abdominal area (AVFA). Objective Clarifying correlations different severities AVFA by magnetic resonance imaging (MRI)....