A5052535915- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Angiogenesis and VEGF in Cancer
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Retinopathy of Prematurity Studies
- Axon Guidance and Neuronal Signaling
- Parallel Computing and Optimization Techniques
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Photoreceptor and optogenetics research
- Embedded Systems Design Techniques
- Cell Adhesion Molecules Research
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Medical Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Corneal Surgery and Treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Inflammasome and immune disorders
- Sleep and related disorders
- Circadian rhythm and melatonin
Guangzhou University of Chinese Medicine
2022-2025
Fujian Medical University
2022-2024
Central South University
2024
Third Xiangya Hospital
2024
Shanxi Medical University
2020-2023
Institute of Automation
2023
University of Chinese Academy of Sciences
2023
Chinese Academy of Sciences
2023
Hospital of Hebei Province
2023
Peking University People's Hospital
2011-2022
Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs retinal IR injury currently unknown. Thus, we investigated the expression and function membrane cytoplasmic during IR.Retinal was induced adult Brown Norway rats by clipping vessels for 30 minutes. RNA proteins were extracted course reperfusion, levels following determined: Toll-like receptor 2 (TLR2), TLR4, myeloid...
Purpose To examine the expression of pro-interleukin-1β (pro-IL-1β) and interleukin-1β (IL-1β) in vitreous body patients with neovascular age-related macular degeneration(nAMD), polypoidal choroidal vasculopathy (PCV), proliferative diabetic retinopathy (PDR), retinal vein occlusion (RVO) or Eales' disease to further elucidate role IL-1β inflammation pathogenesis disease. Design Prospective clinical laboratory investigation study. Methods All enrolled had hemorrhage due nAMD, PCV, PDR, RVO...
<b><i>Purpose:</i></b> The aim of this study was to investigate the effects quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal (RF/6A) cell line. <b><i>Methods:</i></b> RF/6A cells were cultured Dulbecco's modified Eagle's medium containing 10% fetal bovine serum. Then treated with different concentrations (from 0 100 μ<smlcap>M</smlcap>)...
To evaluate the interaction of intraocular pressure(IOP)–lowering medications with physiologic day and night changes in aqueous humor dynamics participants ocular hypertension.Thirty were enrolled thisdouble-masked, randomized, crossover study. Each participant underwent measurements at baseline 2 weeks dosing random order latanoprost evening placebo morning, timolol maleate twice daily, dorzolamide hydrochloride daily. Measurements included central corneal thickness by ultrasound...
Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo. Information on the correlation of SD-OCT with histology porcine retina, model resembling human limited. Herein, we correlated hypo- and hyper-reflective bands lamellar architecture cellular constituents retina. images were acquired Heidelberg Spectralis HRA + OCT. Histological analysis was performed using epoxy resin embedded tissue transmission electron...
• Vogt-Koyanagi-Harada syndrome, or the uveomeningitis is one of most commonly identified types endogenous uveitis diagnosed in China. Because its incidence higher Orientals than whites, immunogenetic backround may be an important factor incidence. We performed HLA-A, -B, and -DR typing on 25 patients with syndrome 65 healthy control subjects from Han Chinese population. The results showed that HLA-DR4 -Dw53 were closely associated (<i>P</i><.001 [relative risk = 16.0] and<i>P</i><.001...
Purpose: Pathological retinal angiogenesis is a major cause of vision loss. Endostatin natural antiangiogenesis antitumor protein that widely used in cancer studies. In this study, we investigated the efficacy and potential mechanisms endostatin for prevention neovascularization both vitro vivo. Methods: Human umbilical vein endothelial cells (HUVECs) were HUVECs incubated with or vascular growth factor (VEGF) different time points. Cell proliferation, migration, cell cycling, tube formation...
Subretinally-deposited amyloid-β (Aβ) is an important factor in age‑related macular degradation (AMD) often leading to irreversible blindness the elderly population. The molecular mechanism underlying Aβ deposition during AMD remains unclear. expression of inflammatory and angiogenic factors was examined by treatment retinal pigment epithelial (RPE) cells with oligomeric form (OAβ1-42). Changes mRNA levels various cytokines detected QuantiGenePlex 6.0 Reagent system, protein level determined...
Diabetic retinopathy (DR), a major complication of diabetes mellitus, is the leading cause adult blindness. The Toll-like receptor (TLR) family believed to be involved in pathogenesis and progression DR. Here, we investigated expression profiles TLR-2 TLR-4 retinal ganglion cells (RGCs), an attempt elucidate role these molecules etiology In vitro cultured RGCs were divided into control high-glucose groups. mRNA protein levels TLR-2, TLR-4, nuclear factor (NF)-κB detected by real-time PCR...
ABSTRACT Long‐chain linear alkylbenzenes (LABs) are essential precursors to produce alkylbenzene sulfonates, which have high surfactant properties and readily biodegradable, widely used in various detergents. However, an effective rapid method for the direct analysis quality control of LAB chemical composition still needs be improved. This study uses high‐performance liquid chromatography coupled with microwave plasma torch mass spectrometry (HPLC‐MPT‐MS) analyze long‐chain LABs quantify...
To investigate whether 11 variants in complement factor H gene contributed differently patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) of Chinese descent.We performed a case-control study group nAMD (n = 344) or PCV 368) contrasted the results against an independent control comprising 511 mild cataract without any evidence maculopathy. Association analysis allele genotype frequencies was for haplotype-tagging single-nucleotide...
As conventional treatments for diabetic wounds often fail to achieve rapid satisfactory healing, the development of effective strategies accelerate wound repair is highly demanded. Herein, fibroblast growth factor 21 (FGF21) and metformin co-loaded multifunctional polyvinyl alcohol (PVA) hydrogel were fabricated improved healing. The in vitro results proved that was adhesive injectable, it could particularly scavenge reactive oxygen species (ROSs), while vivo data demonstrated promote...
When applying optimizations, a number of decisions are made using fixed strategies, such as always an optimization if it is applicable, optimizations in order and assuming configuration for tile size loop unrolling factor. While widely recognized that these strategies may not be the most appropriate producing high quality code, especially embedded systems, there no general automatic do otherwise. In this paper, we present framework enables to based on predicting impact optimization, taking...
To determine the day and night differences in intraocular pressure (IOP), aqueous flow, outflow facility, uveoscleral outflow, central corneal thickness (CCT) juvenile adult rabbits.Studies were performed on twelve 3-month-old ten 12-month-old male New Zealand White rabbits. Daytime measurements made between 9 AM (3 hours after lights on) 3 PM, nighttime 11 PM 5 AM. IOP was measured by pneumotonometry flow fluorophotometry. Outflow facility determined both fluorophotometry tonography....