A5101907240- Helicobacter pylori-related gastroenterology studies
- Retinal Diseases and Treatments
- Gastroesophageal reflux and treatments
- Ocular Diseases and Behçet’s Syndrome
- Advanced Breast Cancer Therapies
- Pharmacovigilance and Adverse Drug Reactions
- Microscopic Colitis
- Drug-Induced Adverse Reactions
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Potassium and Related Disorders
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Inflammatory Bowel Disease
- HER2/EGFR in Cancer Research
- Health disparities and outcomes
- Classical Antiquity Studies
- Chromatin Remodeling and Cancer
- Ocular Oncology and Treatments
- Retinopathy of Prematurity Studies
- Bayesian Methods and Mixture Models
- Herbal Medicine Research Studies
- Male Breast Health Studies
- Viral Infections and Outbreaks Research
- Immunodeficiency and Autoimmune Disorders
Tongji Hospital
2015-2025
Huazhong University of Science and Technology
2015-2025
Peking University People's Hospital
2015-2025
Peking University
2001-2025
Guangzhou Medical University
2021-2024
Sun Yat-sen University
2015-2020
Beth Israel Deaconess Medical Center
2019
University of Arkansas at Fayetteville
2013-2018
Ministry of Education of the People's Republic of China
2015
Purpose To examine the expression of pro-interleukin-1β (pro-IL-1β) and interleukin-1β (IL-1β) in vitreous body patients with neovascular age-related macular degeneration(nAMD), polypoidal choroidal vasculopathy (PCV), proliferative diabetic retinopathy (PDR), retinal vein occlusion (RVO) or Eales' disease to further elucidate role IL-1β inflammation pathogenesis disease. Design Prospective clinical laboratory investigation study. Methods All enrolled had hemorrhage due nAMD, PCV, PDR, RVO...
Background Gonadotrophin-releasing hormone analogs (GnRHas) play a significant role in addressing gynecological diseases, central precocious puberty, and cancer. However, ensuring the safety of GnRHas real-world applications requires continuous vigilance. In light this, we undertook disproportionality analysis focused on adverse events (AEs) associated with using data from both FDA Adverse Event Reporting System (FAERS) Japanese Drug Report (JADER). We evaluated GnRHas-associated AEs...
Anti-IL-5 monoclonal antibodies (mAbs) targeting IL-5 or R α (including mepolizumab, benralizumab, and reslizumab) are widely used for inflammatory diseases such as asthma, eosinophilia, polyangiitis. However, real-world data regarding its safety in a large sample population incomplete. So, we evaluated the of anti-IL-5 mAbs by pharmacovigilance analyzes based on related adverse events (AEs) from FDA Adverse Event Reporting System (FAERS).
To improve the solubility and bioavailability of oridonin (ORI), glycerol monooleate lipid (GMO)- or phytantriol (PYT)-Poloxamer 407-propylene glycol-water systems were firstly used to develop cubosomes containing ORI for oral delivery. These prepared through fragmentation bulk gels under homogenization conditions 1200 bar nine cycles had a mean particle size around 200 nm with narrow distribution, encapsulation efficiency over 85%. Powder X-ray diffraction differential scanning calorimetry...
Abstract Background Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in real world should be continuously monitored. So, we evaluated pertuzumab by pharmacovigilance analyze based on related adverse events (AEs) from FDA Adverse Event Reporting System (FAERS) and find whether potential or uncertain were present. Methods In disproportionality analysis, four algorithms employed to detect signals FAERS between 2012 2022. addition, also MYSQL 8.0, Navicat...
Objectives To explore the association between palbociclib and related adverse events (AEs) in real world through U.S. Food Drug Administration Adverse Event Reporting System (FAERS) database
Background: Prolonged or excessive use of acid suppressants may increase the risk Clostridioides difficile infection (CDI) by altering intestinal microecosystem. Vonoprazan, a novel potassium-competitive blocker, exhibits faster and more sustained acid-suppressive effect than proton pump inhibitors (PPIs). Therefore, vonoprazan have greater impact on gut microbiota, potentially resulting in CDI. Objectives: This study aimed to explore potential relationship between CDI Japan Adverse Drug...
This study aimed to describe the pulmonary toxicity of cyclin-dependent kinase 4/6 inhibitors (CDK inhibitors) (palbociclib, ribociclib, and abemaciclib) in patients being treated for breast cancer using Food Drug Administration Adverse Event Reporting System (FAERS) database. Disproportionality analysis was performed assess associated with CDK inhibitors. Clinical characteristics, onset time, sensitivity analysis, subgroup analyses, drug combinations, comorbidities, co-reported events were...
Purpose To evaluate and contrast the effectiveness safety of two conbercept treatment protocols—a three-dose treat-and-extend (3+T&E) regimen a pro re nata (3+PRN) regimen—in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).
Tumor necrosis factor α (TNF-α) inhibitors are widely used to treat inflammatory bowel disease (IBD), but systematic risk assessment of infectious toxicity is still lacking. We disproportional analysis calculate infection-related signals for four TNF-α and compared them with seven other therapies. There were 55,379 reports adverse events (AEs) as a 'primary suspect (PS)' therapy. The median time onset AEs was 113 days (interquartile range [IQR] 14-612). present the strongest toxic signal...
To evaluate the efficacy and safety of half-dose photodynamic therapy (PDT combined with ranibizumab for polypoidal choroidal vasculopathy (PCV). PCV is commonly treated a combination anti-vascular endothelial growth factor standard-dose (PDT). Choroidal ischemia visual loss can be resulted from PDT. Half-dose PDT has proved to produce similar results profile in treating central serous chorioretinopathy. may offer an alternative cases where damage vasculature maybe less. Here, we report...
Echinocandins belong to the fourth generation of antifungals, and there are no systematic studies on their risk in coagulation dysfunction; this study will predict dysfunction echinocandins using US Food Drug Administration Adverse Event Reporting System (FAERS) database. Data from January 2004 March 2024 were obtained FAERS. We examined clinical characteristics events conducted disproportionality analysis by reporting odds ratios (ROR) compare with full There 313 reports related as primary...
This study was to examine the expression of total vascular endothelial growth factor (VEGF) and anti-angiogenic VEGF 165 b isoform in vitreous body retinopathy prematurity (ROP) patients, further role splicing development ROP.This a prospective clinical laboratory investigation study. All patients enrolled received standard ophthalmic examination with stage 4 ROP that required vitrectomy collect samples. The control samples were from congenital cataract patients. measured by enzyme-linked...
Tumor necrosis factor α (TNF-α) inhibitors are widely used in the treatment of inflammatory bowel disease (IBD), but there is still a lack systematic risk assessment for pulmonary toxicity.
In response to the widespread concern about adequacy, distribution, and disparity of access a health care workforce, correct identification physicians' practice locations is critical public services. prior literature, little effort has been made detect resolve uncertainty whether address provided by physician in survey or home address. This paper introduces how identify physician's location through spatial analytics, text mining, visual examination. While land use zoning code, embedded...
Abstract Bone morphogenetic protein 15 (BMP15), a member of the transforming growth factor beta superfamily, plays an essential role in ovarian follicular development mono-ovulatory mammalian species. Studies using biallelic knockout mouse model revealed that BMP15 potentially has just minimal impact on female fertility and polyovulatory In contrast, our previous study demonstrated vivo knockdown significantly affected porcine fertility, as evidenced by dysplastic ovaries containing...