A5045576282- Epigenetics and DNA Methylation
- Renal and related cancers
- Cancer-related gene regulation
- Chronic Kidney Disease and Diabetes
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Marine and coastal ecosystems
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Renal Diseases and Glomerulopathies
- Microbial Community Ecology and Physiology
- Antibiotic Resistance in Bacteria
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Advanced Glycation End Products research
- Bacteriophages and microbial interactions
- Sugarcane Cultivation and Processing
- Hepatitis C virus research
University of Pennsylvania
2019-2025
First Affiliated Hospital of Zhengzhou University
2016-2025
Yidu Central Hospital of Weifang
2019-2025
China Medical University
2008-2025
University of Rochester
2025
Guilin Medical University
2019-2024
University of Rochester Medical Center
2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
Chinese Academy of Fishery Sciences
2012-2024
Abstract Determining the epigenetic program that generates unique cell types in kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profile open chromatin gene expression developing adult mouse kidneys at single resolution. We show reliance of on distal regulatory elements (enhancers). reveal key type-specific transcription factors major gene-regulatory circuits cells. Dynamic changes nephron progenitor differentiation...
Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation newly signals on common variants European ancestry populations the power population diversity for further discoveries. We defined genotype effects allele-specific gene expression...
AME Aquatic Microbial Ecology Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 12:39-47 (1997) - doi:10.3354/ame012039 Prochlorococcus growth rate and contribution primary production in equatorial subtropical North Pacific Ocean Liu H, Nolla HA, Campbell L DNA synthesis cell division of are tightly synchronized daily light cycle, therefore, rates can be estimated from fraction cells each cycle...
DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling. Differentially methylated regions (DMRs) have important implications for development, aging diseases. Therefore, genome-wide mapping of DMRs across various temporal spatial methylomes is revealing the impact epigenetic modifications on heritable phenotypic variation. We present a quantitative approach, differentially (QDMRs), to quantify difference identify from profiles by adapting Shannon entropy....
The presence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and the permanent integration HBV into host genome confers risk viral reactivation hepatocellular carcinoma. Nucleoside/nucleotide analogues alone have little or no capacity to eliminate replicative templates consisting cccDNA integrated DNA. Recently, CRISPR/Cas9 technology has been widely applied as a promising genome-editing tool, HBV-specific CRISPR-Cas9 systems were shown effectively mediate disruption....
Microscopic analysis of urine sediment is probably the most commonly used diagnostic procedure in nephrology. The urinary cells, however, have not yet undergone careful unbiased characterization.
Genome-wide association studies (GWAS) for kidney function identified hundreds of risk regions; however, the causal variants, target genes, cell types, and disease mechanisms remain poorly understood. Here, we performed transcriptome-wide (TWAS), summary Mendelian randomization, MetaXcan to identify genes whose expression mediates genotype effect on phenotype. Our analyses Dachshund homolog 1 (DACH1), a cell-fate determination factor. GWAS variant was associated with lower DACH1 in human...
Abstract Genome-wide association studies (GWAS) have identified loci for kidney disease, but the causal variants, genes, and pathways remain unknown. Here we identify two disease genes Dipeptidase 1 ( DPEP1 ) Charged Multivesicular Body Protein A CHMP1A via triangulation of function GWAS, human expression, methylation quantitative trait loci. Using single-cell chromatin accessibility genome editing, fine map region that controls expression both genes. Mouse genetic models demonstrate roles...
Inflammation is a common feature of all forms chronic kidney disease; however, the underlying mechanism remains poorly understood. Evolutionarily inherited endogenous retroviruses (ERVs) have potential to trigger an immune reaction. Comprehensive RNA-sequencing control and diseased kidneys from human mouse disease models indicated higher expression transposable elements (TEs) ERVs in kidneys. Loss cytosine methylation causing epigenetic derepression likely contributes increase ERV levels....
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, we perform two independent epigenome-wide association studies to identify methylation associated with baseline estimated glomerular filtration rate (eGFR) subsequent decline in kidney function (eGFR slope), respectively, 1,271 type 2 subjects. Here show 40 (30 previously unidentified) eight (all CpG sites individually reach significance eGFR...
Significance Statement Although gene expression changes have been characterized in human diabetic kidney disease (DKD), unbiased tissue proteomics information for this condition is lacking. The authors conducted an aptamer-based proteomic analysis of samples from patients with DKD and healthy controls, identifying proteins levels that associate function (eGFR) or fibrosis, after adjusting key covariates. Overall, only modestly correlated protein levels. Kidney RNA matrix metalloproteinase 7...
Abstract Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic but are also preserved and transmitted during cell division. We conducted genome-wide cytosine methylation analysis 399 human samples, along with single-nuclear open chromatin on over 60,000 cells from 14 subjects, including controls, diabetes hypertension attributed chronic (CKD) patients. identified validated differentially methylated positions...
Chronic obstructive pulmonary disease (COPD) is gaining increasing attention, with different subtypes being distinguished for separate research and treatment. The emphysema subtype characterized by widespread alveolar destruction, which may be associated aggravated damage abnormal repair. Type II epithelial cells (AEC2s), known their stem cell potential, have recently emerged as a promising target COPD However, to date, few studies elucidated the specific mechanisms AEC2s induce...
DNA methylation is an important epigenetic modification for genomic regulation in higher organisms that plays a crucial role the initiation and progression of diseases. The integration mining data by methylation-specific PCR genome-wide profiling technology could greatly assist discovery novel candidate disease biomarkers. However, this difficult without comprehensive repository human Therefore, we have developed DiseaseMeth, database (http://bioinfo.hrbmu.edu.cn/diseasemeth). Its focus...
DNA methylation is a key epigenetic mark that critical for gene regulation in multicellular eukaryotes. Although various human cell types may have the same genome, these cells different methylomes. The systematic identification and characterization of marks across are crucial to understand complex regulatory network fate determination. In this study, we proposed an entropy-based framework termed SMART integrate whole genome bisulfite sequencing methylomes 42 tissues/cells identified 757 887...