A5082969719- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Neutropenia and Cancer Infections
- Inflammatory Bowel Disease
- S100 Proteins and Annexins
- Microscopic Colitis
- Intensive Care Unit Cognitive Disorders
- Herbal Medicine Research Studies
- Biosimilars and Bioanalytical Methods
- Antifungal resistance and susceptibility
- Maternal and Perinatal Health Interventions
- Pharmacovigilance and Adverse Drug Reactions
- Natural Compounds in Disease Treatment
- Drug-Induced Adverse Reactions
- Immunodeficiency and Autoimmune Disorders
Tongji Hospital
2024-2025
Huazhong University of Science and Technology
2024-2025
Qinghai Red Cross Hospital
2017-2023
Background: Canakinumab, a humanized anti-IL-1β monoclonal antibody, is known for its ability to suppress IL-1β-mediated inflammation. However, continuous monitoring of safety remains essential. Thus, we comprehensively evaluated the signals canakinumab by data mining from FAERS. Methods: We used disproportionate analysis quantify canakinumab-related adverse events (AEs) using four algorithms. Clinical prioritization detected was assessed with semiquantitative score method. Serious and...
Tumor necrosis factor α (TNF-α) inhibitors are widely used to treat inflammatory bowel disease (IBD), but systematic risk assessment of infectious toxicity is still lacking. We disproportional analysis calculate infection-related signals for four TNF-α and compared them with seven other therapies. There were 55,379 reports adverse events (AEs) as a 'primary suspect (PS)' therapy. The median time onset AEs was 113 days (interquartile range [IQR] 14-612). present the strongest toxic signal...
Echinocandins belong to the fourth generation of antifungals, and there are no systematic studies on their risk in coagulation dysfunction; this study will predict dysfunction echinocandins using US Food Drug Administration Adverse Event Reporting System (FAERS) database. Data from January 2004 March 2024 were obtained FAERS. We examined clinical characteristics events conducted disproportionality analysis by reporting odds ratios (ROR) compare with full There 313 reports related as primary...
To investigate the relationships of serum visinin-like protein-1 (VILIP-1), neuron-specific enolase (NSE), and adiponectin (ADP) levels with postoperative cognitive dysfunction (POCD) in elderly patients undergoing general anesthesia provide a reference for prevention treatment POCD.In this retrospective, observational study, 162 who underwent were divided into POCD non-POCD groups according to whether occurred 24 hours after surgery. Serum VILIP-1, NSE, ADP measured.Immediately surgery,...
Objective To evaluate the effect of combined spinal epidural anesthesia with low dose ropivacaine for labor analgesia in highland. Methods One hundred primiparas who were at full term and spontaneous highland assigned randomly two groups(n=50): group(group A) control B). In group A, 0.1% 3 ml given when cervical dilation cm, then patient controlled pump placed epidural. And withdrawn fetus delivered. B, did not accepted any analgesia. BP, HR scores VAS Bromage determined before...