A5020813074- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Diabetes and associated disorders
- Botanical Research and Chemistry
- Barrier Structure and Function Studies
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Thermodynamic properties of mixtures
- Adenosine and Purinergic Signaling
- Obsessive-Compulsive Spectrum Disorders
- Cellular transport and secretion
- Blood groups and transfusion
- Neurological disorders and treatments
- Bipolar Disorder and Treatment
Charité - Universitätsmedizin Berlin
2016-2023
German Center for Neurodegenerative Diseases
2016-2022
Humboldt-Universität zu Berlin
2022
Freie Universität Berlin
2022
University Medical Center of the Johannes Gutenberg University Mainz
2014
Johannes Gutenberg University Mainz
2014
Uppsala University
2013
See Zekeridou and Lennon (doi: 10.1093/aww213 ) for a scientific commentary on this article . Anti- N -methyl-D-aspartate receptor (NMDAR) encephalitis is recently discovered autoimmune syndrome associated with psychosis, dyskinesias, seizures. Little known about the cerebrospinal fluid autoantibody repertoire. Antibodies against NR1 subunit of NMDAR are thought to be pathogenic; however, direct proof lacking as previous experiments could not distinguish contribution further anti-neuronal...
Autoantibodies of the IgG class against N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1) were first described in anti-NMDAR encephalitis and seen as disease indicators. Recent work on together over 5000 individuals challenged this exclusive view by showing age-dependently up to >20% NMDAR1-autoantibody seroprevalence with comparable immunoglobulin titer distribution across health disease. The key question therefore is understand properties these autoantibodies, also healthy carriers, order...
Objective Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of N ‐methyl‐ d ‐aspartate receptor (NMDAR) among most frequently diagnosed anti‐neuronal surface ABs, yet little is known about effects on fetal during pregnancy. Methods We established murine model utero exposure to human recombinant and isotype‐matched nonreactive control ABs. Pregnant C57BL/6J mice were intraperitoneally injected embryonic days...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune presenting with psychosis, dyskinesias, autonomic dysfunction and seizures. The underlying autoantibodies against the NR1 subunit are directly pathogenic by disrupting synaptic NMDAR currents. However, antibody titers correlate only partially clinical outcome, suggesting relevance of other factors such as affinity. We thus determined binding curves human monoclonal patients' cerebrospinal fluid (CSF)...
Abstract Decreased hippocampal connectivity and disruption of functional networks are established resting-state MRI (rs-fMRI) features that associated with neuropsychiatric symptom severity in human anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. However, the underlying pathophysiology NMDAR encephalitis remains poorly understood. Application patient-derived monoclonal antibodies against NR1 (GluN1) subunit now allows for translational investigation experimental murine antibody...
Designing relevant animal models in order to investigate the neurobiological basis for human mental disorders is an important challenge. The need new tests be developed and traditional improved has recently been em-phasized. authors propose a multivariate test approach, concentric square fieldTM (MCSF) test. To measure evaluate variation behavioral traits, we here put forward statistical procedure of which working title “trend analysis”. Low doses benzodiazepine agonist diazepam (DZP; 1.0,...
Abstract Objective To determine whether neurophysiological mechanisms indicating cortical excitability, long‐term potentiation ( LTP )‐like plasticity, GABA ergic and glutamatergic function are altered in patients with anti‐ N ‐methyl‐ d ‐aspartate receptor NMDAR ) encephalitis they can be helpful as markers of diagnostic assessment, disease progression, potentially therapy response. Methods Neurophysiological characterizations n = 34, mean age: 28 ± 11 years; 30 females) age/gender‐matched...
Abstract Introduction While decreased hippocampal connectivity and disruption of functional networks are established MRI features in human anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, the underlying pathophysiology for brain network alterations remains poorly understood. Application patient-derived monoclonal antibodies against NR1 subunit NMDAR allows investigation potential experimental murine antibody disease models. Objective To explore changes mouse models using...