A5033583223- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- RNA regulation and disease
- Genetics and Neurodevelopmental Disorders
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- Cellular transport and secretion
- Obsessive-Compulsive Spectrum Disorders
- Caveolin-1 and cellular processes
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Galectins and Cancer Biology
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Myasthenia Gravis and Thymoma
Euroimmun Medizinische Labordiagnostika (Germany)
2014-2023
Institute for Integrative and Experimental Genomics
2014-2023
Laboratory Krone
2021
Krankenhaus Nordwest
2021
Mayo Clinic
2019-2020
University of Oxford
2020
Universität Innsbruck
2020
Medical University of Vienna
2020
Witten/Herdecke University
2020
Innsbruck Medical University
2020
We previously reported an unexpectedly high seroprevalence (~10%) of N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1) autoantibodies (AB) in healthy and neuropsychiatrically ill subjects (N = 2,817). This finding challenges unambiguous causal relationship serum AB with brain disease. To test whether similar results would be obtained for other antigen-directed connected pathological conditions, we systematically screened samples 4,236 individuals.Serum (n 1,703) versus (schizophrenia,...
To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG MOG-IgM) from 5 international centers.
Relapsing symptoms post herpes simplex virus-1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) true relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, response to acyclovir therapy) or 2) disorder postulated be immune-mediated negative no lesions, acyclovir).1,2 It has been suggested that this may related NMDA receptor (NMDAR) antibodies,3 we recently reported child in whom relapsing were the presentation anti-NMDAR...
To retrospectively determine the frequency of N-Methyl-D-Aspartate (NMDA) receptor (NMDAR) autoantibodies in patients with different forms dementia.Clinical characterization 660 dementia, neurodegenerative disease without other neurological disorders and age-matched healthy controls combined retrospective analysis serum or cerebrospinal fluid (CSF) for presence NMDAR antibodies. Antibody binding to mutants effect immunotherapy were determined a subgroup patients.Serum antibodies IgM, IgA,...
Abstract Patients with COVID-19 can have a variety of neurological symptoms, but the active involvement central nervous system (CNS) in remains unclear. While routine cerebrospinal fluid (CSF) analyses patients manifestations generally show no or only mild inflammation, more detailed data on inflammatory mediators CSF are scarce. We studied response paired and serum samples ( n = 38). herpes simplex virus encephalitis (HSVE, 10) non-inflammatory, non-neurodegenerative diseases 28) served as...
<h3>Objective</h3> Pancreatic autoantibodies (PABs), comprising antibodies against glycoprotein 2 (anti-GP2), are typically associated with complicated phenotypes in Crohn9s disease, but have also been observed variable frequencies patients UC. In a previous study, we high frequency of primary sclerosing cholangitis (PSC) anti-GP2-positive We therefore aimed to characterise the role anti-GP2 PSC. <h3>Design</h3> an evaluation phase, sera from 138 well-characterised Norwegian PSC were...
Background Vaccination has proven to be effective in preventing SARS-CoV-2 transmission and severe disease courses. However, immunocompromised patients have not been included clinical trials real-world data point an attenuated immune response vaccines among with multiple sclerosis (MS) receiving immunomodulatory therapies. Methods We performed a retrospective study including 59 ocrelizumab (OCR)-treated MS who received vaccination. Anti-SARS-CoV-2-antibody titres, routine blood parameters...
Autoantibodies against exocrine pancreas (PAb) have been reported to be pathognomonic markers of Crohn's disease (CD). Recently, the glycoprotein GP2 has proposed as exclusive target for PAb but two equally prevalent binding patterns can observed in indirect immunofluorescence test (IIFT) using cryosections human pancreas: a reticulogranular and droplet pattern. To identify autoantigens corresponding staining patterns. Different lectins were screened their ability immobilize PAb-reactive...
We sought to validate methods for detection and confirmation of GABAA receptor (R)-IgG clinically characterize seropositive cases.Archived serum CSF specimens (185 total) suspected harbor GABAAR-IgG were evaluated by indirect immunofluorescence assay (IFA). Twenty-six from 19 patients appeared suspicious positivity IFA, based on prior reports comparison with commercial GABAAR antibody staining. Aliquots those tested at the University Oxford, United Kingdom, Euroimmun, Lubeck, Germany,...
Background Autoimmune encephalitis associated with anti-neuronal antibodies may be challenging to distinguish from primary psychiatric disorders. The significance of in patients without clear evidence autoimmune is unknown. We investigated the serum prevalence six autoantibodies a cohort unselected admitted acute care. Method Serum was drawn 925 in-patient Psychiatric diagnoses were set according International Classification Diseases (ICD)-10 criteria. Antibody analysis performed an indirect...
Circulating autoantibodies (AB) against brain-antigens, often deemed pathological, receive increasing attention. We assessed predispositions and seroprevalence/characteristics of 49 AB in > 7000 individuals.Exploratory cross-sectional cohort study, investigating deeply phenotyped neuropsychiatric patients healthy individuals GRAS Data Collection for presence/characteristics brain-directed serum-AB. Predispositions were evaluated through GWAS NMDAR1-AB carriers, analyses immune check-point...
To report on a novel neuronal target antigen in 3 patients with autoimmune cerebellar degeneration.Three subacute to chronic ataxia and controls underwent detailed clinical neuropsychological assessment together quantitative high-resolution structural MRI. Sera CSF were subjected comprehensive autoantibody screening by indirect immunofluorescence assay (IFA) immunoblot. Immunoprecipitation lysates of hippocampus cerebellum combined mass spectrometric analysis was used identify the...
Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice.
Inflammatory bowel disease (IBD) is characterized by a broad spectrum of clinical phenotypes with different outcomes. In the last decades, several IBD-associated autoantibodies have been identified and investigated for their diagnostic relevance. Autoantibodies against pancreatic glycoproteins (PAB) CUB zona pellucida-like domains-containing protein 1 (CUZD1), glycoprotein 2 (GP2) demonstrated to possess high specificity diagnosis IBD. Although studies shown significant interrelations...
Abstract Background Previous studies have shown that patients with bullous pemphigoid ( BP ) are more likely to neurological diseases ND ). Objectives To compare clinical findings in and without investigate 180 autoantibody binding different neuronal tissues of mammalians. Methods Our database was searched for in‐patients the definitive diagnosis . Moreover, brain tissue mammalians treated serum elevated autoantibodies using biochip mosaics. Results Of 85/161 (52.8%) had a history at least...
Significance Antibodies recognizing the neuronal gamma-aminobutyric acid A receptor (GABA -R) cause severe encephalitis by triggering internalization of antibody–receptor complexes in inhibitory synapses, which leads to hyperexcitability and dysfunction networks. From cerebrospinal fluid a patient with GABA -R we cloned highly expressed antibody showed that it binds influences signal transduction neurons, explaining clinical symptoms. Using several experimental techniques, confirmed...
Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking. Autoantibodies against septin-5 associated non-paraneoplastic cerebellar ataxia, autoantibodies septin-7 encephalopathy prominent neuropsychiatric features. Here, we report on newly identified septin-3 in patients paraneoplastic ataxia. We also propose a strategy for anti-septin autoantibody determination.Sera...
<title>Abstract</title> Patients with virus encephalitis, such as herpes simplex encephalitis and Japanese frequently relapse autoimmune encephalitides associated neural autoantibodies. It has been hypothesized that the infection-induced damage to central nervous system results in shedding of autoantigens, their presentation peripheral immune system, initiation a secondary targets these autoantigens. To test this hypothesis, we utilized transgenic mouse model virus-like but sterile...
Pancreatic autoantibodies (PAB) targeting GP2 and CUZD1 are Crohn's disease (CrD)-markers. The clinical significance of anti-GP2 antibodies has been assessed, but that anti-CUZD1 remains elusive. aim the study was to assess utility anti-CUZD1/anti-GP2 by novel cell-based indirect immunofluorescence (IIF) assays in CrD.A total 212 CrD 249 UC patients followed up at a London IBD centre were investigated simultaneously detect PABs, IIF using primate pancreatic tissue, HEK293 over-expressing or...