A5087124884- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Ion channel regulation and function
- Cytomegalovirus and herpesvirus research
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Genetic Neurodegenerative Diseases
- Multiple Sclerosis Research Studies
- Biochemical and Molecular Research
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Lymphocytic Leukemia Research
- Electrochemical sensors and biosensors
- IgG4-Related and Inflammatory Diseases
- Immunodeficiency and Autoimmune Disorders
- Tuberous Sclerosis Complex Research
- Platelet Disorders and Treatments
- Biosensors and Analytical Detection
- Celiac Disease Research and Management
- Polyomavirus and related diseases
- Renal Diseases and Glomerulopathies
Euroimmun Medizinische Labordiagnostika (Germany)
2014-2024
Mayo Clinic
2019-2020
University of Oxford
2020
Universität Innsbruck
2020
Medical University of Vienna
2020
Witten/Herdecke University
2020
Innsbruck Medical University
2020
University of California, San Francisco
2019
Institute for Integrative and Experimental Genomics
2017
Heidelberg University
2016
To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG MOG-IgM) from 5 international centers.
Thrombospondin type 1 domain–containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major phospholipase A 2 receptor (PLA R1). The prevalence of THSD7A-Ab–positive patients unknown, and it unclear whether clinical presentation differs between positive for PLA R1-Ab or THSD7A-Ab. We screened serum samples 1276 MN from three different cohorts presence THSD7A-Ab by Western blot analysis newly developed indirect immunofluorescence test (IFT)....
Autoantibodies against the extracellular domains of voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with limbic encephalitis, faciobrachial dystonic seizures, Morvan's syndrome neuromyotonia. However, routine testing, VGKC antibodies without LGI1 or CASPR2 reactivities (double-negative) more common than specificities. Therefore, target(s) clinical associations double-negative...
<h3>Objective</h3> Pancreatic autoantibodies (PABs), comprising antibodies against glycoprotein 2 (anti-GP2), are typically associated with complicated phenotypes in Crohn9s disease, but have also been observed variable frequencies patients UC. In a previous study, we high frequency of primary sclerosing cholangitis (PSC) anti-GP2-positive We therefore aimed to characterise the role anti-GP2 PSC. <h3>Design</h3> an evaluation phase, sera from 138 well-characterised Norwegian PSC were...
We sought to validate methods for detection and confirmation of GABAA receptor (R)-IgG clinically characterize seropositive cases.Archived serum CSF specimens (185 total) suspected harbor GABAAR-IgG were evaluated by indirect immunofluorescence assay (IFA). Twenty-six from 19 patients appeared suspicious positivity IFA, based on prior reports comparison with commercial GABAAR antibody staining. Aliquots those tested at the University Oxford, United Kingdom, Euroimmun, Lubeck, Germany,...
To report on a novel neuronal target antigen in 3 patients with autoimmune cerebellar degeneration.Three subacute to chronic ataxia and controls underwent detailed clinical neuropsychological assessment together quantitative high-resolution structural MRI. Sera CSF were subjected comprehensive autoantibody screening by indirect immunofluorescence assay (IFA) immunoblot. Immunoprecipitation lysates of hippocampus cerebellum combined mass spectrometric analysis was used identify the...
Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice.
Introduction Subgroups of autoantibodies directed against voltage-gated potassium channel (K v ) complex components have been associated with immunotherapy-responsive clinical syndromes. The high prevalence and the role directly binding K remain, however, controversial. Our objective was to determine autoantibody requirements clarify their contribution observed immune response. Methods Binding epitopes were studied in sera (n = 36) cerebrospinal fluid (CSF) 12) from a patient cohort positive...
<h3>Objective</h3> To analyze serum immunoglobulin G (IgG) antibodies to major isoforms of myelin oligodendrocyte glycoprotein (MOG-alpha 1-3 and beta 1-3) in patients with inflammatory demyelinating diseases. <h3>Methods</h3> Retrospective case-control study using 378 samples from multiple sclerosis (MS), non-MS disease, healthy controls MOG alpha-1-IgG positive (n = 202) or negative serostatus 176). Samples were analyzed for their reactivity human, mouse, rat without mutations the...
To report on a Caucasian patient who developed steroid-responsive transverse myelitis, graft vs host disease of the gut, and anti-GluRδ2 after allogenic stem cell transplantation.Histoimmunoprecipitation (HIP) with patient's serum cryosections rat porcine cerebellum followed by mass spectrometry was used to identify autoantigen. Correct identification verified indirect immunofluorescence using recombinant GluRδ2 expressed in HEK293 cells.The produced granular staining cerebellar molecular...
Abstract Objectives To compare the reproducibility of 11 antibody assays for IgG and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG, MOG-IgM) from five international centers. Methods The following samples were analyzed: MOG-IgG clearly positive sera (n=39), low borderline negative (n=13), (n=40), healthy blood donors (n=30). As technical controls, 18 replicates (9 9 negative) included. All controls re-coded, aliquoted, distributed to testing centers which performed assays: live...
Abstract Background Autoantibodies against kelch-like protein 11 (KLHL11) were first described in 2019 as markers of paraneoplastic encephalitis. Early diagnosis and treatment are imperative to improve prognosis outcome affected patients. Rat brain immunohistochemistry was reported be not useful routine screening for KLHL11 antibodies. This study evaluates the performance a new recombinant cell-based assay standardized detection KLHL11-specific IgG reports characteristics examined Methods...
Background: Autoantibodies against inosine-5′-monophosphate dehydrogenase 2 (IMPDH2; “rings and rods” pattern) develop in chronic hepatitis C (CHC) patients under treatment with peg-interferon (IFN) ribavirin (RBV), an inhibitor of IMPDH2. We investigated the influence alternative therapy a regimen including direct acting antivirals (DAA)/ribavirin on anti-IMPDH2 autoantibody generation use development as marker for outcome (sustained virologic response, SVR).