A5033798967- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Autoimmune Neurological Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Migraine and Headache Studies
- Infectious Encephalopathies and Encephalitis
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Biochemical effects in animals
- Lanthanide and Transition Metal Complexes
- Intracranial Aneurysms: Treatment and Complications
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Dysphagia Assessment and Management
- Neurological Disorders and Treatments
- Tracheal and airway disorders
University Hospital Schleswig-Holstein
2014-2025
University of Lübeck
2015-2025
University of Thessaly
2023-2024
Harvard University
2023
Universitätsklinikum Würzburg
2021-2023
Charité - Universitätsmedizin Berlin
2005-2021
University Hospital of Basel
2021
Universität Hamburg
2021
University Medical Center Hamburg-Eppendorf
2021
Atrial Fibrillation NETwork
2021
Background: Andexanet alfa is a modified recombinant inactive factor Xa (FXa) designed to reverse FXa inhibitors. ANNEXA-4 (Andexanet Alfa, Novel Antidote the Anticoagulation Effects of Factor Inhibitors) was multicenter, prospective, phase-3b/4, single-group cohort study that evaluated andexanet in patients with acute major bleeding. The results final analyses are presented. Methods: Patients bleeding within 18 hours inhibitor administration were enrolled. Co-primary end points anti-FXa...
Local and peripheral immune responses are activated after ischemic stroke. In our present study, we investigated the temporal distribution, location, induction, function of regulatory T cells (Tregs) possible involvement microglia, macrophages, dendritic middle cerebral artery occlusion (MCAO). C57BL/6J Foxp3 EGFP transgenic mice were subjected to 30 minutes MCAO. On days 7, 14, MCAO, Tregs antigen presenting analyzed using fluorescence cell sorting multicolor staining immunohistochemistry....
The coupling of cerebral blood flow (CBF) to neuronal activity is well preserved during evolution. Upon changes in the activity, an incompletely understood mechanism regulates diameter supplying vessels, which adjust CBF within seconds. physiologic brain tissue oxygen content would sustain unimpeded function for only 1 second if continuous supply suddenly stop. This suggests that response has evolved balance and demand. Surprisingly, increases surpass accompanying metabolic rate (CMRO2)....
Dizziness is among the most frequent neurological chief complaints in emergency room (ER) patients. Although majority of underlying disorders are benign, serious causes that require immediate in-hospital treatment may occur difficult to identify clinically.Retrospective study 475 consecutive ER consultations with dizziness as complaint.Of all patients, 73% were initially assigned benign and 27% diagnoses. The two paroxysmal positional vertigo (22%) stroke (20%). On follow-up (available 124...
<b><i>Background:</i></b> Dysphagia is associated with poor outcome in stroke patients. Studies investigating the association of dysphagia and early screening (EDS) outcomes patients acute ischemic (AIS) are rare. The aims our study to investigate EDS within 24 h stroke-related pneumonia outcomes. <b><i>Methods:</i></b> Over a 4.5-year period (starting November 2007), all consecutive AIS from 15 hospitals Schleswig-Holstein, Germany, were...
Benefit of thrombectomy in patients with a low initial Alberta Stroke Program Early CT Score (ASPECTS) is still uncertain. We hypothesized that, despite ASPECTS, may benefit from endovascular recanalization if good collaterals are present.Ischemic stroke large vessel occlusion the anterior circulation and an ASPECTS ≤5 were analyzed. Collateral status (CS) was assessed using 5-point-scoring system angiography poor CS defined as CS=0-1. Clinical outcome determined modified Rankin Scale (mRS)...
We used Monte Carlo simulations and the diffusion approximation to estimate correction terms for analysis of reflectance spectra cortical intrinsic optical signals. These corrections depend on scattering absorption properties, i.e. they are dependent assumptions tissue blood content oxygen saturation. The was applied acquired during whisker barrel stimulation in rat where attenuation were converted changes oxygenated deoxygenated haemoglobin concentration. description experimental data as...
Stroke leads to energy failure and subsequent neuronal cell loss. Creatine phosphocreatine constitute a cellular buffering transport system, dietary creatine supplementation was shown protect neurons in several models of neurodegeneration. Although has recently been found reduce infarct size after cerebral ischemia mice, the mechanisms neuroprotection remained unclear. We provide evidence for augmented blood flow (CBF) stroke creatine-treated mice using magnetic resonance imaging (MRI)-based...
Stroke-induced immunodepression (SIDS) is an essential cause of poststroke infections. Pharmacological inhibition SIDS appears promising in preventing life-threatening infections stroke patients. However, might represent adaptive mechanism autoreactive immune responses after stroke. To address this, we used myelin oligodendrocyte glycoprotein (MOG) T-cell receptor transgenic (2D2) mice where >80% peripheral CD4(+) T cells express a functional for MOG. We investigated murine model middle...
Meta-analyses of case series non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question.
Recently, a universal, simple, and fail-safe mechanism has been proposed by which cerebral blood flow (CBF) might be coupled to oxygen metabolism during neuronal activation without the need for any tissue-based mechanism. According this concept, vasodilation occurs local erythrocytic release of nitric oxide or ATP wherever whenever hemoglobin is deoxygenated, directly matching demand supply in every tissue. For neurovascular coupling brain, we present experimental evidence challenging view...
Neurovascular coupling provides the basis for many functional neuroimaging techniques. Nitric oxide (NO), adenosine, cyclooxygenase, CYP450 epoxygenase, and potassium are involved in dilating arterioles during neuronal activation. We combined inhibition of NO synthase, adenosine receptors, inward rectifier (Kir) channels to test whether these pathways could explain blood flow response Cerebral (CBF) cerebral metabolic rate oxygen (CMRO 2 ) somatosensory cortex were measured forepaw...
Abstract Background and purpose A mobile stroke unit (MSU) reduces delays in treatment by allowing thrombolysis on board avoiding secondary transports. Due to the beneficial effect comparison conventional emergency medical services, current guidelines recommend regional evaluation of MSU implementation. Methods In a descriptive study, pathways patients requiring transport for mechanical thrombectomy were reconstructed from individual patient records within Danish ( n = 122) an adjacent...
Matrix metalloproteinases (MMPs) have been implicated in the pathophysiology of cerebral ischemia. In this study, we explored whether MMP activity can be visualized by noninvasive near-infrared fluorescence (NIRF) imaging using an MMP-activatable probe a mouse model stroke. C57BI6 mice were subjected to transient middle artery occlusion (MCAO) or sham operation. Noninvasive NIRF was performed 24 h after injection, and target-to-background ratios (TBRs) between two hemispheres determined....
To evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers in patients with probable cerebral amyloid angiopathy (CAA) according to modified Boston criteria a retrospective multicentric cohort.Beta-amyloid 1-40 (Aβ40), beta-amyloid 1-42 (Aβ42), total tau (t-tau), and phosphorylated 181 (p-tau181) were measured 31 CAA, 28 Alzheimer's disease (AD), 30 controls. Receiver-operating characteristics (ROC) analyses performed for parameters as well Aβ42/40 ratio estimate parameters....
Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because the potential genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require knowledge brain–blood partition coefficient ( BBPC) for water. Adopting an protocol described by Roberts et al (1996) humans, we determined BBPC water 129S6/SvEv mice from proton density measurements brain and blood, calibrated...
In the emergency room, distinguishing between a migraine with aura and transient ischemic attack (TIA) is often not straightforward mistakes can be harmful to both patient society. To account for this difficulty, third edition of International Classification Headache disorders (ICHD-3) changed diagnostic criteria aura.One hundred twenty-eight patients referred room at University Hospital Lübeck, Germany suspected TIA were prospectively interviewed about their symptoms leading admission...
The optimal timing of initiating or resuming anticoagulation after acute ischemic stroke (AIS) transient attack (TIA) in patients with atrial fibrillation (AF) is debated. Dabigatran, a non-vitamin K oral anticoagulant (NOAC), has shown superiority against vitamin antagonists (VKA) regarding hemorrhagic complications.
Background Excessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection. Methods and Results The investigator‐initiated, prospective, open, multicenter MonDAFIS (Impact of Standardized Monitoring Detection Atrial Fibrillation in Ischemic Stroke) study randomized 3465 patients with acute ischemic stroke without known AF 1:1 to usual diagnostic procedures detection or additive Holter monitoring hospital up 7 days, analyzed core...
Abstract Neuroscience has evolved by framing numerous neuropsychiatric conditions as network diseases. Alterations within neurotransmitter (NT) systems are central to the development of these Recently, normative data on whole-brain NT fingerprints derived from PET tracer become accessible; limited related such information sequelae after stroke. This work aims explore (1) integration into structural connectivity analyses and (2) its potential contribution understanding outcome variability...