A5101759809- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Magnetic Properties and Applications
- Cerebrovascular and Carotid Artery Diseases
- Prostate Cancer Treatment and Research
- Pain Management and Treatment
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Prostate Cancer Diagnosis and Treatment
- Neuroscience and Music Perception
- Motor Control and Adaptation
- Cardiovascular Health and Disease Prevention
- Spatial Cognition and Navigation
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2015-2025
Klinik und Poliklinik für Neurologie
2015-2024
Medical University of Vienna
2024
John Wiley & Sons (United States)
2019
Hudson Institute
2019
Freie Universität Berlin
2016
Cognitive Neuroimaging Lab
2015
Eppendorf (Germany)
2015
University of Rostock
2011-2013
Background and Purpose— Aside from the primary motor cortex, corticospinal tract (CST) also receives fibers dorsal ventral premotor cortices supplementary area, all of which might potentially contribute to function after stroke. We sought quantify microstructural integrity CST originating hand representations in these 4 separately examined how values related impairment. Methods— Probabilistic tractography functional MRI-defined cortical sites demonstrated continuous within each area a group...
The aim of this study was to investigate the relationship between stroke lesion location and resulting somatosensory deficit. We studied exteroceptive proprioceptive symptoms lesions in 38 patients with first-ever acute stroke. Erasmus modified Nottingham Sensory Assessment used clinically evaluate functioning arm hand within first week after onset. Additionally, more objective measures such as perceptual threshold touch evoked potentials were recorded. Non-parametric voxel-based...
Corticocortical interactions between the primary motor cortex, ventral premotor cortex and posterior parietal areas, such as anterior caudal intraparietal sulcus, are relevant for skilled voluntary hand function. It remains unclear to what extent these brain regions their also contribute basic functions after stroke. We hypothesized that white matter integrity of underlying parietofrontal pathways might relate residual function Twenty-five chronic stroke patients were recruited (aged 64 ±...
Functional imaging studies have argued that interactions between cortical motor areas and the cerebellum are relevant for output recovery processes after stroke. However, impact of underlying structural connections is poorly understood. To investigate this, diffusion-weighted brain was conducted in 26 well-characterized chronic stroke patients (aged 63 ± 1.9 years, 18 males) with supratentorial ischemic lesions healthy participants. Probabilistic tractography used to reconstruct reciprocal...
Objective The majority of patients with stroke survive the acute episode and live enduring disability. Effective therapies to support recovery motor function after are yet be developed. Key this development is identification neurophysiologic signals that mark suitable susceptible interventional therapies. Movement preparatory low‐frequency oscillations (LFOs) play a key role in cortical control movement. Recent animal data point mechanistic LFOs deficits demonstrate neuromodulation...
Ischemic strokes with motor deficits lead to widespread changes in neural activity and interregional coupling between primary secondary areas. Compared frontal circuits, the knowledge is still limited what extent parietal cortices their interactions areas undergo plastic might contribute residual functioning after stroke.Fifteen well-recovered patients were evaluated 3 months stroke by means of functional magnetic resonance imaging while performing visually guided hand grips paretic hand....
Corticocortical functional interactions between the primary motor cortex (M1) and secondary areas, such as dorsal (PMd) ventral (PMv) premotor cortices supplementary area (SMA) are relevant for residual output after subcortical stroke. We hypothesized that microstructural integrity of underlying white matter tracts also plays a role in preserved output. Using diffusion-tensor imaging we aimed at (i) reconstructing individual probable intrahemispheric connections M1 three areas (PMd, PMv,...
Cortical atrophy as demonstrated by measurement of cortical thickness (CT) is a hallmark various neurodegenerative diseases. In the wake an acute ischemic stroke, brain architecture undergoes dynamic changes that can be tracked structural and functional magnetic resonance imaging studies soon 3 months after stroke. this study, we measured CT in areas connected to subcortical stroke lesions 12 patients with upper extremity paresis combining white-matter tractography semi-automatic using...
Following acute ischemic stroke, isolated subcortical lesions induce gray matter atrophy in anatomically connected, yet distant cortical brain regions. We expand on previous studies by analyzing thinning contralesional, homologous regions indirectly linked to primary stroke via ipsilesional areas. For this purpose, patients were serially studied magnetic resonance imaging (diffusion tensor and high-resolution anatomical imaging) the (days 3–5) late chronic stage one year after stroke....
Motor recovery after stroke shows a high inter-subject variability. The brain's potential to form new connections determines individual levels of motor function. Most our daily activities require visuomotor integration, which engages parietal areas. Compared the frontal system, less is known about system's reconfiguration related recovery. Here, we tested if functional connectivity among and areas undergoes plastic changes assessed behavioral relevance for function stroke. We investigated...
Force generation is a crucial element of dexterity and highly relevant skill the human motor system. How cerebral spinal components interact how activation associated with activity in primary premotor areas poorly understood. Here, we conducted combined cortico-spinal functional magnetic resonance imaging during simple visually guided isometric force task 20 healthy young subjects. Activation was localized right cervical cord left areas. The main finding that negatively correlated ventral...
Abstract Small-molecule fragments binding to biomacromolecules can be starting points for the development of drugs, but are often difficult detect due low affinities. Here we present a strategy that identifies protein-binding through their potential induce target-guided formation covalently bound, irreversible enzyme inhibitors. A nucleophile reacts reversibly with bis-electrophilic warhead, thereby positioning second electrophile in close proximity active site viral protease, resulting...
Abstract Beyond disruption of neuronal pathways, focal stroke lesions induce structural disintegration distant, yet connected brain regions via retrograde degeneration. Stroke alter functional connectivity and topology in large-scale networks. These changes are associated with the degree clinical impairment recovery. In contrast, large scale, networks after less well reported. We therefore aimed to analyse impact on connectome based data from diffusion-weighted imaging probabilistic fibre...
Imaging studies have evidenced that contralesional cortices are involved in recovery after motor stroke. Cortical thickness (CT) analysis has proven its potential to capture the changes of cortical anatomy, which been related and treatment gains under therapy. An open question is whether CT obtained acute phase stroke might inform correlational models explain outcome variability. Data 38 severely impaired (median NIH Stroke Scale 9, interquartile range: 6-13) patients 2 independent cohorts...
The concept of brain reserve capacity positively influencing the process recovery after stroke has been continuously developed in recent years. Global measures health have linked with a favourable outcome. Numerous studies evidenced that cerebellum is involved stroke. However, it remains an open question whether characteristics cerebellar anatomy, quantified directly stroke, might impact on subsequent outcome Thirty-nine first-ever ischaemic non-cerebellar patients underwent MRI imaging...
In this study we explore the spatio-temporal trajectory and clinical relevance of microstructural white matter changes within beyond subcortical stroke lesions detected by free-water imaging. Twenty-seven patients with infarct mean age 66.73 (SD 11.57) median initial NIHSS score 4 (IQR 3-7) received diffusion MRI 3-5 days, 1 month, 3 months, 12 months after symptom-onset. Extracellular fractional anisotropy tissue (FA
The dentato-thalamo-cortical tract (DTCT) connects the lateral cerebellum with contralateral motor and nonmotor areas, such as primary cortex (M1), ventral premotor (PMv), dorsolateral prefrontal (DLPFC). As acquisition of precisely timed finger movements requires interplay between these brain regions, structural integrity underlying connections might explain variance in behavior. Diffusion tensor imaging was used to 1) reconstruct DTCT connecting dentate nucleus M1, PMv, DLPFC 2) examine...
Hand motor function is often severely affected in stroke patients. Non-satisfying recovery limits reintegration into normal daily life. Understanding stroke-related network changes and identifying common principles that might underlie recovered a prerequisite for the development of interventional therapies to support recovery. Here, we combine evaluation functional activity (multichannel electroencephalography) structural integrity (diffusion tensor imaging) order explain degree residual...
Abstract Motor cortical high‐gamma oscillations (60–90 Hz) occur at movement onset and are spatially focused over the contralateral primary motor cortex. Although widely recognized for their significance in human control, precise function on a level remains elusive. Importantly, relevance stroke pathophysiology is unknown. Because deficits fundamental determinants of symptom burden after stroke, understanding neurophysiological processes coding could be an important step improving...
Neuroscience research has contributed significantly to understanding alterations in brain structure and function after ischemic stroke. Technical limitations have excluded the spinal cord from imaging-based research. Available data are restricted a few microstructural analyses, functional connectivity absent. The present study attempted close this knowledge gap assess corticospinal coupling chronic stroke their relation motor deficits. In cross-sectional study, patients with healthy controls...