A5035674058- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Hereditary Neurological Disorders
- EEG and Brain-Computer Interfaces
- Pain Management and Treatment
- Glycogen Storage Diseases and Myoclonus
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Linguistic research and analysis
- Cerebral Palsy and Movement Disorders
- Functional Brain Connectivity Studies
- Ion channel regulation and function
- Therapeutic Uses of Natural Elements
- Attention Deficit Hyperactivity Disorder
- Diphtheria, Corynebacterium, and Tetanus
- Cerebrospinal fluid and hydrocephalus
- Healthcare and Venom Research
- Medical Practices and Rehabilitation
- Parkinson's Disease Mechanisms and Treatments
- Spinal Cord Injury Research
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
Schön Klinik Bad Aibling
2007-2023
Technical University of Munich
1995-1999
Goethe University Frankfurt
1997
Heidelberg University
1997
Max Planck Society
1992
We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration high doses gamma-aminobutyric acid (GABA)B receptor agonist baclofen in patient with generalized dystonia. Size motor potentials and central conduction time remained unchanged administration. The selective high-dose therapy supports notion that GABAB-ergic intracortical interneurons play part generation period. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:1209–1212, 1998.
Lesions of the central nervous system often result in an upper motor neuron syndrome including spasticity, paresis with pyramidal signs, and painful spasms. Pharmacological treatment oral antispasticity drugs is frequently associated systemic side effects which limit their clinical use. Botulinum Toxin A (BtxA) injected spastic muscles has been shown to be effective reducing muscle tone, but only few studies have reported pain relief as additional benefit. Therefore, we investigated local...
We report on eight patients with stiff-man syndrome (SMS) or its "plus" variant, progressive encephalomyelopathy rigidity and myoclonus (PERM) receiving intrathecal baclofen via pump. In six of the patients, follow-ups continued for approximately 2.5 to 6.5 years after pump implantation. Intrathecal was an effective last-resort alternative who responded poorly did not tolerate oral antispasticity medications. General mobility increased, spasms were reduced; however, no complete remissions...
Robotic therapy and serious gaming support motor learning in neurorehabilitation. Traditional monitor-based outputs cannot adequately represent the third dimension, whereas virtual reality headsets lack connection to real world. The use of Augmented Reality (AR) techniques could potentially overcome these issues. objective this study was thus evaluate usability, feasibility functionality a novel arm rehabilitation device for neurorehabilitation (RobExReha system) based on robotic (LBR iiwa,...
Abstract Intrathecal baclofen dramatically improves severe spastic syndromes. This improvement is likely related to reduced excitability of alphamotoneurons. To investigate the influence upon alphamotoneuron, we analyzed F‐waves before and after intrathecal bolus injection (usually 50 μg) as well administration different, constantly delivered doses (60–200 μg/day). decreased maximum F‐wave amplitude (F p ) from an initial value 9% M (M max (=F/M‐ratio) 2.4% 130–180 min, mean 60% within 150...
To investigate whether the dose of intrathecal baclofen necessary for a sufficient reduction muscle tone and spasms changes during treatment severe spasticity.A group 27 patients received 61 (SD 18) months.Spasticity remained absent or strongly reduced after stopping infusion in seven patients. The could be to 40% that which was originally 10 same increased slightly Possible reasons continuing spasticity terminating long term some be: lasting morphological spinal cord neurons by second...
We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration high doses gamma-aminobutyric acid (GABA)B receptor agonist baclofen in patient with generalized dystonia. Size motor potentials and central conduction time remained unchanged administration. The selective high-dose therapy supports notion that GABAB-ergic intracortical interneurons play part generation period. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:1209–1212, 1998.
Continuous intrathecal baclofen infusion (CIBI) is a highly effective treatment for severe spasticity, especially of spinal origin.1-2 The beneficial effect CIBI on spasticity related to its gamma-aminobutyric acid (GABA)B-ergic action interneurons, resulting in profound depression disinhibited mono- and polysynaptic reflexes.1-3 Although the effects reflexes have been studied detail,2-4 corticofugal projections motor neurons not characterized. This study used transcranial magnetic...
Ziel der Untersuchung ist eine Objektivierung des Edrophonium-Tests durch instrumentelle Messung Nasalität bei Sprechern mit Myasthenia Gravis (MG). Ein Hauptsymptom oropharyngealer MG das hypernasale Sprechen. Bei Artikulation zahlreicher Laute Deutschen muss Gaumensegel angehoben werden, um den Nasenraum abzuschließen und Luftstrom oral führen zu können. Hypernasalität entsteht als Folge velaren Schwäche. Die Injektion von Edrophonium Diagnostik soll die neuromuskuläre Übertragung an...
Ein Hauptsymptom oropharyngealer Myasthenien ist das hypernasale Sprechen, Folge einer Gaumensegelschwäche ist. Die Injektion von Edrophonium bei der Diagnostik Myasthenia gravis soll die neuromuskuläre Übertragung an motorischen Endplatte und damit Gaumensegelfunktion Myasthenie verbessern. In bisherigen klinischen Praxis wird Veränderung Nasalität anhand subjektiver Höreindrücke beurteilt. vorliegenden Untersuchung ein modifizierter Edrophonium-Test vorgestellt mit dem Ziel, subjektive zu...
Epileptic discharges can be elicited through different stimuli. In conscious patients hyperventi-lation and intermittent photic stimulation is used, in comatose other modalities such as reagebi-lity to auditory, tactile visual stimuli are tested.
Abstract Introduction The WHO estimates that each year 5 million people are left permanently disabled after stroke. Adjuvant treatments to promote the effects of rehabilitation urgently needed. Cortical excitability and neuroplasticity can be enhanced by non-invasive brain stimulation but evidence from sufficiently powered, randomized controlled multi-center clinical trials is absent. Methods Neuroregeneration transcranial direct current (tDCS) in stroke (NETS) tested efficacy safety anodal...
Ein 24-jähriger Patient entwickelte nach einem Lawinenunfall ein posthypoxisches Lance Adams Syndrom und eine fokale Reflexepilepsie. Die kognitiven Fähigkeiten hatten sich im Verlauf wieder der altersentsprechenden Norm angenähert. Trotz mehrfacher antiepileptischer Therapie mit Leviteracetam, Valproat, Lorazepam Piracetam wegen des Syndroms traten weiter Aktionsmyoklonien beim Gehen Sprechen auf. Schreiben ging besser, es aber immer Myoklonien Bei spezifischen rechtshemisphärisch...