A5038812031- Transcranial Magnetic Stimulation Studies
- Motor Control and Adaptation
- Vestibular and auditory disorders
- Functional Brain Connectivity Studies
- Muscle activation and electromyography studies
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Action Observation and Synchronization
- Tactile and Sensory Interactions
- Neuroscience and Neural Engineering
- Trigeminal Neuralgia and Treatments
- Memory and Neural Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Multisensory perception and integration
- Neuroscience and Music Perception
- Neurological disorders and treatments
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Hemispheric Asymmetry in Neuroscience
- Stroke Rehabilitation and Recovery
University Medical Center Hamburg-Eppendorf
2012-2022
Universität Hamburg
2012-2022
Cognitive Neuroimaging Lab
2015
Eppendorf (Germany)
1976-2015
Functional imaging studies have argued that interactions between cortical motor areas and the cerebellum are relevant for output recovery processes after stroke. However, impact of underlying structural connections is poorly understood. To investigate this, diffusion-weighted brain was conducted in 26 well-characterized chronic stroke patients (aged 63 ± 1.9 years, 18 males) with supratentorial ischemic lesions healthy participants. Probabilistic tractography used to reconstruct reciprocal...
Cerebellar transcranial direct current stimulation (tDCS) has the potential to modulate cerebellar outputs and visuomotor adaptation. The cerebellum plays a pivotal role in acquisition control of skilled hand movements, especially its temporal aspects. We applied anodal tDCS concurrently with training synchronization-continuation motor task. hypothesized that will enhance skill acquisition. was right 31 healthy subjects double-blind, sham-controlled, parallel design. During synchronization,...
Practicing a previously unknown motor sequence often leads to the consolidation of chunks, which enable its accurate execution at increasing speeds. Recent imaging studies suggest function these structures be more related encoding, storage, and retrieval sequences rather than their sole execution. We found that optimal skill acquisition prioritizes storage spatial features in memory over rapid early training, as proposed by Hikosaka 1999. This process, seemingly diminished older adults, was...
Physiological aging is paralleled by a decline of fine motor skills accompanied structural and functional alterations the underlying brain network. Here, we aim to investigate age-related changes in spectral distribution neuronal oscillations during skilled function. We employ concept entropy order describe flatness peaked-ness frequency spectrum quantify oscillatory response aged brain. Electroencephalogram was recorded elderly (n = 32) young 34) participants who performed either cued...
The dentato-thalamo-cortical tract (DTCT) connects the lateral cerebellum with contralateral motor and nonmotor areas, such as primary cortex (M1), ventral premotor (PMv), dorsolateral prefrontal (DLPFC). As acquisition of precisely timed finger movements requires interplay between these brain regions, structural integrity underlying connections might explain variance in behavior. Diffusion tensor imaging was used to 1) reconstruct DTCT connecting dentate nucleus M1, PMv, DLPFC 2) examine...
Cognitive difficulties are the most common neurological complications in neurofibromatosis type 1 (NF1) patients. Recent animal models proposed increased GABA-mediated inhibition as one underlying mechanism directly affecting induction of long-term potentiation (LTP) and learning. In adult NF1 patients, apparent cognitive attentional deficits, tumors nervous system other confounding factors for neuroscientific studies difficult to control for. Here we used a highly specific group patients...
Abstract Brain imaging has recently evidenced that the structural state of distinct reciprocal cortico-cerebellar fiber tracts, dentato-thalamo-cortical tract (DTCT), and cortico-ponto-cerebellar (CPCeT), significantly influences residual motor output in chronic stroke patients, independent from level damage to corticospinal (CST). Whether such information might also directly relate measures cortical excitability is an open question. Eighteen patients with supratentorial ischemic lesions 17...
Hand motor function is often severely affected in stroke patients. Non-satisfying recovery limits reintegration into normal daily life. Understanding stroke-related network changes and identifying common principles that might underlie recovered a prerequisite for the development of interventional therapies to support recovery. Here, we combine evaluation functional activity (multichannel electroencephalography) structural integrity (diffusion tensor imaging) order explain degree residual...
Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient rigid habitual linking responses preceding stimuli. Recent evidence suggests that inferolateral prefrontal cortex (ilPFC), region well known contribute cognitive control processes, may play crucial role in responding. This evidence, however, comes mainly from correlational data whether ilPFC is indeed...
Abstract Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative protocols, accounting related brain network interactions also, may further enhance effect sizes. Here, we tested different targeting the cerebro-cerebellar loop. Forty young, healthy participants trained a fine skill with concurrent tDCS...
Interhemispheric interactions demonstrate a crucial role for directing bimanual movement control. In humans, well-established paired-pulse transcranial magnetic stimulation paradigm enables to assess these by means of interhemispheric inhibition (IHI). Previous studies have examined changes in IHI from the active resting primary motor cortex during unilateral muscle contractions; however, behavioral relevance such is still inconclusive. present study, we evaluated two tasks, i.e., mirror...
Abstract During learning of novel motor sequences, practice leads to the consolidation hierarchical structures, namely chunks, facilitating accurate execution sequences at increasing speeds. Recent studies show that such structures are largely represented upstream primary cortex in network, suggesting their function be more related encoding, storage, and retrieval rather than sole execution. We isolated different components skill acquisition spatiotemporal features followed evolution over...