A5005025074- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- NMR spectroscopy and applications
- Atomic and Subatomic Physics Research
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Spinal Dysraphism and Malformations
- Bone and Joint Diseases
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Spinal Cord Injury Research
- Pain Management and Placebo Effect
- RNA regulation and disease
- Transcranial Magnetic Stimulation Studies
- Musculoskeletal pain and rehabilitation
- Motor Control and Adaptation
- Pain Mechanisms and Treatments
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Medical Imaging and Analysis
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
Universität Hamburg
2015-2025
University Medical Center Hamburg-Eppendorf
2015-2025
Temple University
2012
Shriners Hospitals for Children - Erie
2012
University Medical Center
2012
Aarhus University Hospital
2009
Max Planck Institute for Biophysical Chemistry
1999-2004
Universitätsmedizin Göttingen
2004
Max Planck Society
1999-2003
Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging human spinal cord to test hypothesis placebo results in reduction nociceptive processing cord. In line with behavioral data show decreased responses under placebo, pain-related activity strongly reduced placebo. These provide direct evidence for inhibition as one mechanism and highlight can act earliest stages central nervous system.
Price modulates early pain processing Patients in randomized clinical trials frequently stop taking their drug, complaining of side effects. However, it turns out that some these subjects are part the placebo group and thus never received any active medication. This is a case nocebo effect seriously interfering with medical treatment. Tinnermann et al. investigated whether value information such as price medication can further modulate behavioral effects underlying neural network dynamics...
MRI techniques such as quantitative imaging and parallel transmit require precise knowledge of the radio-frequency field (B(1) (+)). Three published methods were optimized for robust B(1) (+) mapping at 3T in human brain: three-dimensional (3D) actual flip angle (AFI), 3D echo-planar (EPI), two-dimensional (2D) stimulated echo acquisition mode (STEAM). We performed a comprehensive comparison methods, focusing on artifacts, reproducibility, accuracy compared to reference 2D double method. For...
Significance The human brain displays an enormous amount of intrinsic activity in the absence any task or external stimulation. Here we demonstrate that spinal cord, brain’s principal interface with body, also shows such resting-state activity. We observed biologically plausible and spatially distinct networks reflect functional organisation cord: anterior part likely relating to motor function posterior reflecting sensory function. These were grouped along consistent output to, input from,...
Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with...
Abstract Two‐dimensional spatially‐selective RF (2DRF) excitation pulses were developed for single‐shot echo‐planar imaging (EPI) with reduced field of view (FOV) in the phase‐encoding direction. The decreased number k ‐space lines significantly shortens length EPI echo train. Thus, both gradient‐echo and spin‐echo 2DRF‐EPI images human brain at 2.0 T exhibit markedly susceptibility artifacts regions close to major air cavities. Based on a blipped‐planar trajectory, implementation typical...
Double wave vector diffusion weighting uses gradients along two different directions between excitation and acquisition. It has been shown theoretically that for restricted the signal amplitude in such an experiment can depend on angle gradient vectors. The highest is obtained with antiparallel orientation, difference parallel orientations depends compartment size. validity of this description experimentally tested water polymer beads, radish, porcine spinal cord, using a clinical MR system...
Abstract It has recently been suggested that learning signals in the amygdala might be best characterized by attentional theories of associative [such as Pearce–Hall ( PH )] and more recent hybrid variants combine Rescorla–Wagner models. In these models, unsigned prediction errors PE s) determine associability a cue, which is used turn to control outcome expectations dynamically reflects function reliability prior predictions. Here, we employed an aversive Pavlovian reversal‐learning task...
The dynamic interaction between ascending spinocortical nociceptive signaling and the descending control of dorsal horn (DH) by brain regions such as periaqueductal gray matter (PAG) plays a critical role in acute chronic pain. To noninvasively investigate processing stimuli humans, previous fMRI studies either focused exclusively on or, more recently, spinal cord. However, to relate neuronal responses cord assess functional interplay both sites normal aberrant conditions, within one...
The study of spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signal has recently been extended from brain to spinal cord. Two ultra-high field functional magnetic resonance imaging (fMRI) studies humans have provided evidence for reproducible resting-state connectivity between dorsal horns as well ventral horns, and a non-human primates shown that these signals are impacted by cord injury. As were carried out at strengths using region-of-interest (ROI) based analyses, we...
Abstract In animals, 17-beta-estradiol (E2) enhances hippocampal plasticity in a dose-dependent, monotonically increasing manner, but this relationship can also exhibit an inverted U-shaped function. To investigate E2’s dose-response function the human hippocampus, we pharmacologically increased E2 levels 125 naturally cycling women (who were their low-hormone menstruation phase) to physiological (equivalent menstrual cycle peak) and supraphysiological during early pregnancy) concentrations...
In the absence of any task, both brain and spinal cord exhibit spontaneous intrinsic activity organised in a set functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across is unclear. Here, we used unique scanning protocol to acquire functional images cervical (CSC) simultaneously examined their spatiotemporal correspondence humans. We show that activities strongly correlated during rest periods, specific regions linked consistently...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
<b>BACKGROUND AND PURPOSE:</b> Physiologic age-related T2* and T2′ values are required as reference for comparison with disease-related deviations. In our study, (T2 control) were determined MR imaging in healthy subjects to determine standard investigate changes. <b>MATERIALS METHODS:</b> Data of 50 patients without intraparenchymal pathology 10 acute stroke who underwent including a T2 sequence 3 echotimes included. After calculation T2*, T2′, maps, the gray matter (GM) white (WM) each...
Background and Purpose— We hypothesize that in comparison to diffusion-weighted imaging, quantitative T2 values (qT2) are more directly related water uptake ischemic tissue, depending on time from symptom onset. measured the increase of qT2 infarct core quantify correlation between onset change qT2. Methods— Thirty-six patients with acute stroke territory proximal middle cerebral artery underwent MRI including fluid-attenuated inversion recovery, a triple-echo sequence (calculation maps)...
Abstract It can be difficult to clinically distinguish between classical Parkinson's disease (PD) and progressive supranuclear palsy. Previously, there have been no biomarkers that reliably allow this distinction made. We report an abnormal brain iron accumulation is a marker for ongoing neurodegeneration in both conditions, but the conditions differ with respect anatomical distribution of these accumulations. analyzed quantitative T2′ maps as markers regional content from PD palsy patients...
To demonstrate the applicability of inner field-of-view (FOV) echo-planar imaging based on spatially two-dimensional selective radiofrequency excitations to high-resolution diffusion tensor imaging.Diffusion FOVs with in-plane resolutions 0.90 x mm(2) and 0.50 was performed in human brain cervical spinal cord a 3 T whole-body MR system.Using reduces geometric distortions allows for an improved resolution. Some crossings transverse pontine fibers pyramidal tracts brainstem could be resolved,...
Diffusion‐tensor imaging is widely used to characterize diffusion in biological tissue, however, the derived anisotropy information, e.g., fractional anisotropy, ambiguous. For instance, low values of brain white matter voxels may reflect a reduced axon density, i.e., loss fibers, or lower fiber coherence within voxel, more crossing fibers. This ambiguity can be avoided with experiments involving two diffusion‐weighting periods applied successively single acquisition, so‐called...