A5079541670- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Innovations in Medical Education
- Simulation-Based Education in Healthcare
- Medical Education and Admissions
- Functional Brain Connectivity Studies
- Electron Spin Resonance Studies
- Radiomics and Machine Learning in Medical Imaging
- Diversity and Career in Medicine
- MRI in cancer diagnosis
- Advanced NMR Techniques and Applications
- Clinical Reasoning and Diagnostic Skills
- Climate Change Communication and Perception
- Medical Imaging and Analysis
- NMR spectroscopy and applications
- Spinal Dysraphism and Malformations
- Optical Imaging and Spectroscopy Techniques
- Healthcare professionals’ stress and burnout
- Climate Change and Health Impacts
- Health, psychology, and well-being
- Medical Imaging Techniques and Applications
- Cervical and Thoracic Myelopathy
- Patient Safety and Medication Errors
- Radiology practices and education
- Advanced X-ray Imaging Techniques
Max Planck Institute for Human Cognitive and Brain Sciences
2018-2025
Universitätsklinikum Würzburg
2022-2024
University Teaching Hospital
2023
Max Planck Society
2018-2021
Otto-von-Guericke University Magdeburg
2011-2019
Neuroscience and clinical researchers are increasingly interested in quantitative magnetic resonance imaging (qMRI) due to its sensitivity micro-structural properties of brain tissue such as axon, myelin, iron water concentration. We introduce the hMRI-toolbox, an open-source, easy-to-use tool available on GitHub, for qMRI data handling processing, presented together with a tutorial example dataset. This toolbox allows estimation high-quality multi-parameter maps (longitudinal effective...
Abstract Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites scanner manufacturers, as well time points. We therefore implemented multiparameter mapping (MPM) protocol based on vendor's product sequences demonstrate its repeatability for whole‐brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], effective transverse [R2*]...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
The hMRI toolbox is an open-source for the calculation of quantitative MRI parameter maps from a series weighted imaging data, and optionally additional calibration data. multi-parameter mapping (MPM) protocol, incorporating data to correct spatial variation in scanner's transmit receive fields, most complete protocol that can be handled by toolbox. Here we present dataset acquired with such full MPM which made freely available used as tutorial following instructions provided on associated...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...
The connections between climate, environment, and health as well the concept of planetary need to be integrated into education professionals, is increasingly demanded both internationally nationally. Planetary should also aim foster transformative action for climate protection sustainability. In recent years, innovative teaching formats objective catalogues have emerged internationally. Germany, these topics not yet been medical everywhere. Since 2021, Faculty Medicine in Würzburg has...
Given the shortage and unequal distribution of physicians across specialties, we aimed to evaluate factors associated with medical students' career choices, including background, personality traits, educational experience, personal interests, lifestyle considerations, awareness work requirements.
Abstract Background Needle-stick injuries (NSIs) pose a safety risk for healthcare workers with great potential serious infections. The aim was to determine numbers and causes of NSIs as well the frequency which medical students report in final stages study. Methods An online questionnaire developed made available January February 2023 all undergraduate ( n = 423) last 1.5 years their degree course at Würzburg University, Germany. Results response rate 19.6% 84). Among respondents, 27.4% 23)...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...
Short MRI acquisition time, high signal-to-noise ratio, and reliability are crucial for image quality when scanning healthy volunteers patients. Cross-sectional cervical cord area (CSA) has been suggested as a marker of neurodegeneration potential outcome measure in clinical trials is conventionally measured on T1-weigthed 3D Magnetization Prepared Rapid Acquisition Gradient-Echo (MPRAGE) images. This study aims to reduce the time comprehensive assessment spinal cord, which typically based...
MRI based multicenter studies which target neurological pathologies affecting the spinal cord and brain - including injury (SCI) require standardized acquisition protocols image processing methods. We have optimized applied a multi-parameter mapping (MPM) protocol that simultaneously covers cervical within traveling heads study across six clinical centers (Leutritz et al., 2020). The MPM includes quantitative maps (magnetization transfer saturation (MT), proton density (PD), longitudinal...
Abstract Water–macromolecule exchange induces a bulk water frequency shift contributing to the contrast in phase imaging. For separating effects of water–macromolecule and macromolecule susceptibility, appropriate internal or external references are needed. In this study, two reference compounds, 2,2,3,3‐tetradeuterio‐3‐trimethylsilyl‐propionate (TMSP) 1,4‐dioxane, were used study macromolecule‐dependent bovine serum albumin (BSA)–water system detail. TMSP, depended on both BSA concentration...
Multi-parameter mapping (MPM) magnetic resonance imaging (MRI) provides quantitative estimates of the longitudinal and effective transverse relaxation rates R1 R2*, proton density (PD), magnetization transfer saturation (MTsat). Thereby, MPM enables better comparability across sites time than conventional weighted MRI. However, for MPM, several contrasts must be acquired, resulting in prolonged measurement durations thus preventing MPM's application clinical routines. State-of-the-art...
Background Objective structured clinical examinations (OSCEs) are a widely recognized and accepted method to assess competencies but often resource-intensive. This study aimed evaluate the feasibility effectiveness of virtual reality (VR)–based station (VRS) compared with traditional physical (PHS) in an already established curricular OSCE. Methods Fifth-year medical students participated OSCE consisting 10 stations. One stations, emergency medicine, was offered 2 modalities: VRS PHS....
Abstract Background The growing shortage of General Practitioners (GPs) is a Europe-wide challenge, particularly in rural areas. In Germany, the situation worsened by an ageing workforce GPs and insufficient training new doctors. Many newly qualified physicians choose careers outside primary care or prefer to work part-time balance family life. To address this problem, it essential understand factors that influence medical students’ specialty choice, then take action encourage them...
<sec> <title>BACKGROUND</title> Objective structured clinical examinations (OSCEs) are a widely recognized and accepted method to assess competencies but often resource-intensive. Moreover, they may not comprehensively capture the complexity of emergency scenarios. </sec> <title>OBJECTIVE</title> This study aimed evaluate feasibility effectiveness virtual reality (VR) station compared traditional physical stations in an already established curricular OSCE. <title>METHODS</title> Fifth-year...
Abstract Testing based on multiple choice questions (MCQ) is one of the most established forms assessment, not only in medical field. Extended matching (EMQ) represent a specific type MCQ designed to require higher levels cognition, such as problem-solving. The purpose this evaluation was assess suitability and efficiency EMQ an assessment method. were incorporated into end-of-semester examination internal medicine, which 154 students participated, compared with three types. Item quality...
Purpose Investigation of magnetic susceptibility and chemical exchange as sources MRI phase contrast between gray white matter resulting from protein iron content subcellular fractions. Methods This study analyzes the macromolecule different fractions rat brain their relation to water‐resonance frequency by NMR spectroscopy. Additionally, contributions were determined with reference substances. Results Only weak correlations ( r = 0.4318, P 0.76) or 0.4704, 0.70) shift observed. After...
<h2>Abstract</h2><h3>Background</h3> Climate change is the greatest threat to human health. Medical students, as future health-care workers, are important in promoting sustainable behaviours, which strongly associated with individuals' emotional responses climate change. At Würzburg University Hospital (Würzburg, Germany), a one-term optional course (40 learning units) about planetary health and two lectures within curricular Environmental Medicine were introduced 2021. We aimed examine...