A5086856273- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Epilepsy research and treatment
- Medical Image Segmentation Techniques
- Cell Image Analysis Techniques
- Neurobiology of Language and Bilingualism
- Spinal Cord Injury Research
- Cerebral Palsy and Movement Disorders
- NMR spectroscopy and applications
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Advanced NMR Techniques and Applications
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Hereditary Neurological Disorders
- Dysphagia Assessment and Management
- Medical Imaging and Analysis
- Spinal Dysraphism and Malformations
- Neurological disorders and treatments
- Retinal and Optic Conditions
- Neurogenesis and neuroplasticity mechanisms
- Spinal Fractures and Fixation Techniques
University Medical Center Hamburg-Eppendorf
2016-2025
Max Planck Institute for Human Cognitive and Brain Sciences
2017-2025
Universität Hamburg
2016-2025
University of Lübeck
2024-2025
Max Planck Institute for Human Development
2023-2025
Max Planck Society
2020-2025
Islamic Azad University South Tehran Branch
2025
University of Zurich
2019-2024
Laboratory for Social and Neural Systems Research
2024
University Hospital Schleswig-Holstein
2024
Neuroscience and clinical researchers are increasingly interested in quantitative magnetic resonance imaging (qMRI) due to its sensitivity micro-structural properties of brain tissue such as axon, myelin, iron water concentration. We introduce the hMRI-toolbox, an open-source, easy-to-use tool available on GitHub, for qMRI data handling processing, presented together with a tutorial example dataset. This toolbox allows estimation high-quality multi-parameter maps (longitudinal effective...
C-reactive protein is a marker of inflammation and vascular disease. It also seems to be associated with an increased risk dementia. To better understand potential underlying mechanisms, we assessed microstructural brain integrity cognitive performance relative serum levels high-sensitivity (hs-CRP).We cross-sectionally examined 447 community-dwelling stroke-free individuals from the Systematic Evaluation Alteration Risk Factors for Cognitive Health (SEARCH) Study (mean age 63 years, 248...
Abstract Eddy‐current (EC) and motion effects in diffusion‐tensor imaging (DTI) bias the estimation of quantitative diffusion indices, such as fractional anisotropy. Both can be retrospectively corrected by registering strongly distorted diffusion‐weighted images to less‐distorted T2‐weighted acquired without weighting. Two different affine spatial transformations are usually employed for this correction: slicewise whole‐brain transformations. However, a relation between estimated...
Several studies have shown that obesity is associated with changes in human brain function and structure. Since women are more susceptible to than men, it seems plausible neural correlates may also be different. However, this has not been demonstrated so far. To address issue, we systematically investigated the brain's white matter (WM) structure 23 lean obese (mean age 25.5 y, std 5.1 y; mean body mass index (BMI) 29.5 kg/m2, 7.3 kg/m2) 26 men 27.1 5.0 BMI 28.8 6.8 diffusion-weighted...
The g-ratio, quantifying the ratio between inner and outer diameters of a fiber, is an important microstructural characteristic fiber pathways functionally related to conduction velocity. We introduce novel method for estimating MR g-ratio non-invasively across whole brain using high-fidelity magnetization transfer (MT) imaging single-shell diffusion MRI. These methods enabled us map in vivo brain's prominent group 37 healthy volunteers estimate inter-subject variability. Effective...
The longitudinal relaxation rate (R1 ) measured in vivo depends on the local microstructural properties of tissue, such as macromolecular, iron, and water content. Here, we use whole brain multiparametric data a general linear relaxometry model to describe dependence R1 these components. We explore a) validity having single fixed set coefficients for b) stability large cohort.Maps magnetization transfer (MT) effective transverse (R2 *) were used surrogates macromolecular iron content,...
<b>Background:</b> Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized (IGE) without structural brain abnormalities detectable by MRI or CT. <b>Objective:</b> In the present study, we addressed question whether diffusion tensor (DTI) can detect disease-specific white matter (WM) in patients with JME. <b>Methods:</b> We performed whole head DTI at 3 T 10 JME, 8 age-matched cryptogenic partial (CPE), and 67 healthy volunteers. Nerve fiber integrity was compared between...
Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders. It is important assess the specificity and validity of measurements structure volumes respect reliable manual methods that rely on human anatomical expertise. The thalamus widely investigated many neuropsychiatric disorders using MRI, but thalamic notoriously difficult quantify given poor between-tissue contrast at...
Purpose: Patients with juvenile myoclonic epilepsy (JME) show evidence of microstructural white matter (WM) damage thalamocortical fiber tracts and changes blood oxygen level dependent (BOLD) signal in a striatothalamocortical network. The objective the present study was to investigate volumetric alterations putamen patients JME using diffusion tensor imaging (DTI) conventional magnetic resonance (MRI). Methods: We performed DTI MRI for 10 59 age-matched neurologically healthy volunteers....
Individuals with developmental prosopagnosia (DP) experience face recognition impairments despite normal intellect and low-level vision no history of brain damage. Prior studies using diffusion tensor imaging in small samples subjects DP (n=6 or n=8) offer conflicting views on the neurobiological bases for DP, one suggesting white matter differences two major long-range tracts running through temporal cortex, another confined to fibers local ventral face-specific functional regions interest...
Relaxation rates provide important information about tissue microstructure. Multi-parameter mapping (MPM) estimates multiple relaxation parameters from multi-echo FLASH acquisitions with different basic contrasts, i.e., proton density (PD), T1 or magnetization transfer (MT) weighting. Motion can particularly affect maps of the apparent transverse rate R2*, which are derived signal PD-weighted images acquired at echo times. To address motion artifacts, we introduce ESTATICS, robustly R2* even...
The NODDI-DTI signal model is a modification of the NODDI that formally allows interpretation standard single-shell DTI data in terms biophysical parameters healthy human white matter (WM). contains no CSF compartment, restricting application to voxels without partial-volume contamination. This allowed derivation analytical relations between representing axon density and dispersion, invariants (MD FA) from model. These allow extraction data. were estimated by applying proposed first shell...
Abstract Magnetic resonance imaging (MRI) has become the prime technique for in vivo examination of brain. In addition to anatomical and functional MRI, diffusion MRI (dMRI) is widely used both clinics research assess tissue structure fiber directions, particularly nervous system. While tensor most widespread approach assessing orientation measures, other, more sophisticated models have also been proposed. Validation dMRI is, however, a challenging endeavor that requires specialized test...
Diffusion tensor imaging (DTI) provides information about the microstructure in brain and spinal cord. While new neuroimaging techniques have significantly advanced accuracy sensitivity of DTI brain, quality cord data has improved less. This is part due to small size (ca. 1cm diameter) more severe instrumental (e.g. eddy current) physiological cardiac pulsation) artefacts present DTI. So far, improvements image resolution resulted from gating acquisition approaches reduced field-of-view...
Abstract In this prospective study, we made an unbiased voxel-based analysis to investigate above-stenosis spinal degeneration and its relation impairment in patients with cervical spondylotic myelopathy (CSM). Twenty 18 controls were assessed high-resolution MRI protocols above the level of stenosis. Cross-sectional areas grey matter (GM), white (WM) posterior columns (PC) measured determine atrophy. Diffusion indices tract-specific integrity PC lateral corticospinal tracts (CST)....
To investigate whether gray matter pathology above the level of injury, alongside white changes, also contributes to sensorimotor impairments after spinal cord injury.
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration across the entire neuraxis. However, spatiotemporal dynamics of grey white matter above below is understudied. Methods We acquired longitudinal data from 13 traumatic 3 patients (8–8 cervical thoracic injuries) within 1.5 years after 10 healthy controls over same period. The protocol encompassed structural diffusion-weighted MRI rostral (C2/C3) caudal (lumbar enlargement) to level track tissue-specific...
It has long been suspected that cortical interhemispheric asymmetries may underlie hemispheric language dominance (HLD). To test this hypothesis, we determined using stereology and MRI of three regions hypothesized to be related HLD (Broca's area, planum temporale, insula) in healthy adults whom was functional transcranial Doppler sonography (15 left HLD, 10 right HLD). We observed no relationship between volume asymmetry the gyral correlates Broca's area or temporale HLD. However, a robust...