A5058566851- Suicide and Self-Harm Studies
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Psychiatric care and mental health services
- Mental Health Treatment and Access
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Genomics and Rare Diseases
- Education, Healthcare and Sociology Research
- Neurotransmitter Receptor Influence on Behavior
- Genomic variations and chromosomal abnormalities
- Tryptophan and brain disorders
- Animal Ecology and Behavior Studies
- Homicide, Infanticide, and Child Abuse
- Psychotherapy Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Patient Involvement
- Receptor Mechanisms and Signaling
- Empathy and Medical Education
- Poisoning and overdose treatments
- Genetic Syndromes and Imprinting
- Congenital heart defects research
University of the Faroe Islands
1981-2025
Amager Hospital
2010-2025
Copenhagen University Hospital
2010-2025
Shandong First Medical University
2024
Mental Health Services
2013-2019
University of Copenhagen
2005-2019
Aarhus University
2016-2017
Lundbeck Foundation
2016
University of Southern Denmark
2016
Capital Region of Denmark
2013-2016
Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with identification of regulatory microRNAs (miRNAs) as important brain development and function, miRNAs emerged candidates schizophrenia-associated genetic factors. Indeed, growing understanding properties pleiotropic effects that miRNA on molecular cellular mechanisms, suggests alterations interactions between their mRNA may contribute to phenotypic variation.We studied association...
From October 1, 1980 to April 20, 1981, 207 patients were admitted the Department of Psychiatry, Odense University Hospital, after attempting suicide. Information on physical, mental and social conditions was collected. The then followed for 5 years, register subsequent suicidal behaviour try identify relevant factors evaluation future suicide risk. During follow‐up period 11.6% attempters committed suicide, majority within first year index attempt. Seventy‐five percent suicides less than 6...
Repetition after attempted suicide is high but only few effect studies have been carried out. The Baerum Model from Norway offers practical and affordable intervention for those not being offered psychiatric treatment. During a period 2005–2007, all patients except with major diagnoses (schizophrenia, bipolar disorder, severe/psychotic depression), were participation. group received the OPAC programme (outreach, problem solving, adherence, continuity) control treatment as usual (TAU). was 6...
ABSTRACT– During a 6 months’ period, 99 persons, randomly chosen among patients admitted for attempted suicide to the Department of Psychiatry, Odense University Hospital, were interviewed. This paper, which is first in series, deals with theoretical and methodological background survey validity sample also some basic social characteristics attempters. The majority attempters found be single many them living alone or children. could characterized by low level vocational education lack...
Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two its functional single polymorphisms (SNPs; C677T and A1298C) schizophrenia. Studies also MTHFR A1298C variation bipolar disorder. In a replication attempt SNPs were analyzed in three Scandinavian schizophrenia case-control samples. addition, Norwegian patients with disorder investigated. There no statistically significant allele or genotype differences. The present results do...
INTRODUCTION. The Faroe Islands are a country in the North Atlantic with population of approximately 53,000 inhabitants. suicide incidence rate is very low, at some 5/100,000 annual suicides. Faroese school system participates European School Survey Project (ESPAD) every four years, organised by Department Occupational Medicine and Public Health. This study aimed to describe frequency attempts ideation among ninth-grades Faroes elucidate risk factors. METHODS. Data from ESPAD surveys were...
OBJECTIVE: The 32-bp deletion allele in chemokine receptor CCR5 has been associated with several immune-mediated diseases and might be implicated schizophrenia as well. METHOD: authors genotyped DNA samples from 268 patients 323 healthy subjects. Age at first admission to a psychiatric hospital department served measure of disease onset. RESULTS: Patients comparison subjects differed marginally their genotype distribution, slightly higher frequency the seen patients. found age admission....
Objective: To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual‐III (DSM‐III) in‐patients. Method: A total 210 previous participants multicentre antidepressant drug trials, carried out randomized double‐blind design, were followed prospectively through maximum 10 years. Patients with or alcohol abuse excluded. The association between and the pretreatment profile was analysed using survival statistics. Results: rate...
Abstract Background Schizophrenia is a highly heritable complex psychiatric disorder with an underlying pathophysiology that still not well understood. Metaanalyses of schizophrenia linkage studies indicate numerous but rather large disease-associated genomic regions, whereas accumulating gene- and protein expression have indicated equally set candidate genes only partially overlap genes. A thorough assessment, beyond the resolution current GWA studies, disease risk conferred by daunting...
Abstract Bipolar disorder affects about 1% of the world’s population, and its estimated heritability is 75%. Only few whole genome or whole-exome sequencing studies in bipolar have been reported, no rare coding variants yet robustly identified. The use isolated populations might help finding with a recent origin, more likely to drifted higher frequency by chance. Following this approach, we investigated 28 cases 214 controls from Faroe Islands exome sequencing, results were followed-up...
Chromosome 22q may harbor risk genes for schizophrenia and bipolar affective disorder. This is evidenced through genetic mapping studies, investigations of cytogenetic abnormalities, direct examination candidate genes. Patients with disorder from the Faroe Islands were typed 35 evenly distributed polymorphic markers on in a search shared two disorders. No single marker was strongly associated either disease, but five two-marker segments that cluster within regions chromosome have haplotypes...
Background Psychosocial therapy after deliberate self-harm might be associated with reduced risk of specific causes death. Method In this matched cohort study, we included patients, who an episode received psychosocial at a Suicide Prevention Clinic in Denmark between 1992 and 2010. We used propensity score matching 1:3 ratio to select comparison group from 59 046 individuals standard care. National Danish registers supplied data on death over 20-year follow-up period. Results At the end...
The Faroe Islands are a small group of islands in the North Atlantic Ocean, situated between Norway, Iceland and Scotland. origin population is thought to be mixture Norwegian, Danish British. were populated at same time as Iceland, i.e. around 1100 years ago, size was around, occasionally below, 4000 inhabitants until 1800, after which it increased its present-day level 45000. descended from Scandinavian British ancestors. Because low number founders for many centuries, Faroese perhaps most...