Jérôme Nicod
A5031874980- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Hormonal Regulation and Hypertension
- Genetic and phenotypic traits in livestock
- Genetic Associations and Epidemiology
- Biosensors and Analytical Detection
- Animal testing and alternatives
- Single-cell and spatial transcriptomics
- COVID-19 and healthcare impacts
- Genetics and Neurodevelopmental Disorders
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- COVID-19 diagnosis using AI
- Language Development and Disorders
- Spaceflight effects on biology
- Genomics and Chromatin Dynamics
The Francis Crick Institute
2018-2025
Genomics (United Kingdom)
2025
Centre for Human Genetics
2010-2021
University of Oxford
2008-2021
University College London Hospitals NHS Foundation Trust
2020
University College London
2020
National Hospital for Neurology and Neurosurgery
2020
Royal Marsden Hospital
2020
University Hospital of Bern
2002-2006
Hypertension Institute
2004
We report genome sequences of 17 inbred strains laboratory mice and identify almost ten times more variants than previously known. use these genomes to explore the phylogenetic history mouse examine functional consequences allele-specific variation on transcript abundance, revealing that at least 12% transcripts show a significant tissue-specific expression bias. By identifying candidate 718 quantitative trait loci we molecular nature their position relative genes vary according effect size...
Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of influence more common phenotypes, such as specific impairment.
Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations the human FOXP2 gene cause monogenic speech language disorder. Reduced functional dosage mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity impairs motor-skill learning. Moreover, songbird orthologue appears critically important for vocal Across diverse vertebrate...
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with discovery of molecular signatures stress, some which include alterations an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between stress-related disease, major depression, and amount mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence interval [CI] 1.29-1.37]) telomere length 2.84 10(-14), 0.85 CI...
Lung cancer is the leading cause of cancer-associated mortality worldwide
Abstract B cells are frequently found in the margins of solid tumours as organized follicles ectopic lymphoid organs called tertiary structures (TLS) 1,2 . Although TLS have been to correlate with improved patient survival and response immune checkpoint blockade (ICB), underlying mechanisms this association remain elusive Here we investigate lung-resident cell responses patients from TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) other lung cancer cohorts, a...
Abstract Recognition and elimination of pathogens cancer cells depend on the adaptive immune system. Thus, accurate quantification subsets is vital for precision medicine. We present lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell B fractions, class switching clonotype diversity whole-genome data at depths as low 5× coverage. By applying ImmuneLENS to 100,000 Genomes Project, we identify genes enriched with somatic mutations in cell-rich tumors,...
The most well-described example of an inherited speech and language disorder is that observed in the multigenerational KE family, caused by a heterozygous missense mutation FOXP2 gene [1Lai C.S. Fisher S.E. Hurst J.A. Vargha-Khadem F. Monaco A.P. A forkhead-domain mutated severe disorder.Nature. 2001; 413: 519-523Crossref PubMed Scopus (1430) Google Scholar]. Affected individuals are characterized deficits learning production complex orofacial motor sequences underlying fluent display...
Mutations in the FOXP2 gene cause a severe communication disorder involving speech deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments expressive and receptive language. The protein encoded belongs to divergent subgroup of forkhead-box transcription factors, with distinctive DNA-binding domain motifs that mediate hetero- homodimerization. Here we report first direct functional genetic investigation missense nonsense mutations using human cell-lines, including...
Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated comparison same two iPSC lines across five distinct laboratories. Despite uncovering acceptable variability within individual laboratories, detect poor cross-site differential gene expression signature between these lines. Factor analysis identifies laboratory as largest source variation along...
Genome-wide association studies using commercially available outbred mice can detect genes involved in phenotypes of biomedical interest. Useful populations need high-frequency alleles to ensure high power quantitative trait loci (QTLs), low linkage disequilibrium between markers obtain accurate mapping resolution, and an absence population structure prevent false positive associations. We surveyed 66 colonies for inbreeding, genetic diversity, disequilibrium, we demonstrate that some have...
Traditionally, sleep studies in mammals are performed using electroencephalogram/electromyogram (EEG/EMG) recordings to determine sleep-wake state. In laboratory animals, this requires surgery and recovery time causes discomfort the animal. study, we evaluated performance of an alternative, noninvasive approach utilizing piezoelectric films wakefulness mice by simultaneous EEG/EMG recordings. The detect animal's movements with high sensitivity regularity piezo output signal, related regular...
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling clinical annotation. Of 357 patients cancer, 118 were SARS-CoV-2 positive, 94 symptomatic 2 died of COVID-19. In this cohort, 83% had S1-reactive antibodies 82% neutralizing against wild type SARS-CoV-2, whereas antibody titers Alpha, Beta Delta variants substantially reduced. levels decreased in 13% patients, remained stable for up to...
Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as kidney largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using...
The emergence of successive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants concern (VOCs) during 2020 to 2022, each exhibiting increased epidemic growth relative earlier circulating variants, has created a need understand the drivers such growth. However, both pathogen biology and changing host characteristics—such as varying levels immunity—can combine influence replication transmission SARS-CoV-2 within between hosts. Disentangling role variant in individual-level...
Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose synthesis is directed by transcription regulatory sequences (TRSs) in the 5′ genomic leader upstream each body open reading frame. In SARS-CoV-2, TRS has consensus AAACGAAC; upon searching for emergence this motif global SARS-CoV-2 sequences, we find that it evolves frequently, especially 3′ end genome. We show well-supported examples Spike gene—within nsp16 coding region ORF1b—which expressed...
Background SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought characterise symptoms viral loads the course COVID-19 with these in otherwise-healthy, vaccinated, non-hospitalised adults, compared data infections preceding Delta concern (VOC). Methods In a prospective, observational cohort study, healthy vaccinated UK adults who reported positive polymerase chain reaction (PCR) or lateral flow test,...
Background In recent years, the assessment of plasma aldosterone-to-renin ratio (ARR) has become an established screening method for diagnosis primary aldosteronism. Plasma renin activity (PRA) is usually measured to define ARR although, increasingly, concentration alone often in clinical routine. Objective To determine threshold using active screen Design and participants based on immunoreactive (irR), we aldosterone (PAC), irR PRA 36 hypertensive patients, nine thereof with adrenal...
Abstract Two mutations occurred in SARS-CoV-2 early during the COVID-19 pandemic that have come to define circulating virus lineages 1 : first a change spike protein (D614G) defines B.1 lineage and second, double substitution nucleocapsid (R203K, G204R) B.1.1 lineage, which has subsequently given rise three Variants of Concern: Alpha, Gamma Omicron. While latter appear unremarkable at level, there are dramatic implications nucleotide level: GGG→AAC generates new Transcription Regulatory...