Annika Fendler
A5028849214- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Chemical Reactions and Isotopes
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
Charité - Universitätsmedizin Berlin
2011-2025
The Francis Crick Institute
2020-2025
Freie Universität Berlin
2011-2025
Humboldt-Universität zu Berlin
2023-2025
Ecologic Institute
2011-2024
Max Delbrück Center
2012-2024
Royal Marsden NHS Foundation Trust
2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response. Genomic analyses show no correlation between molecular features and response, whereas ccRCC-specific human endogenous retrovirus expression indirectly correlates clinical T receptor (TCR) analysis reveals significantly higher number expanded TCR...
Abstract Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is prospective cohort study of COVID-19 immunity patients with cancer. Here we evaluated 585 following administration two doses BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after were 85% and 59% solid hematological malignancies, respectively. A lower proportion had detectable titers neutralizing antibodies (NAbT) against severe acute...
Abstract B cells are frequently found in the margins of solid tumours as organized follicles ectopic lymphoid organs called tertiary structures (TLS) 1,2 . Although TLS have been to correlate with improved patient survival and response immune checkpoint blockade (ICB), underlying mechanisms this association remain elusive Here we investigate lung-resident cell responses patients from TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) other lung cancer cohorts, a...
Abstract Current treatments for clear cell renal cancer (ccRCC) are insufficient because two-thirds of patients with metastases progress within two years. Here we report the identification and characterization a stem (CSC) population in ccRCC. CSCs quantitatively correlated tumor aggressiveness metastasis. Transcriptional profiling single sequencing reveal that these exhibit an activation WNT NOTCH signaling. A significant obstacle to development rational has been discrepancy between model...
Piwi-interacting RNAs (piRNAs) are small of 27-30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role cancerogenesis. This study is the first one investigating their prognostic impact clear cell renal cancer (ccRCC) patients.Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on basis initial piRNA microarray analyses were determined using RT-qPCR non-metastatic (n = 76) metastatic 30) ccRCC tissue at time...
Abstract Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported vaccines and is an extremely rare immune-related adverse event immune checkpoint inhibitors. We present a case CRS that occurred 5 d after BTN162b2 (tozinameran)—the Pfizer-BioNTech COVID-19 vaccine—in patient colorectal on long-standing anti-PD-1 monotherapy. The was...
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling clinical annotation. Of 357 patients cancer, 118 were SARS-CoV-2 positive, 94 symptomatic 2 died of COVID-19. In this cohort, 83% had S1-reactive antibodies 82% neutralizing against wild type SARS-CoV-2, whereas antibody titers Alpha, Beta Delta variants substantially reduced. levels decreased in 13% patients, remained stable for up to...
Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant dynamics remain limited. We investigated spatial and temporal features diversification in clear cell renal carcinoma through a combination modelling real tumour analysis. observe that the mode growth, surface or volume, impacts extent subclonal diversification, enabling interpretation diversity patient tumours. Specific patterns proliferation necrosis explain expansion emergence parallel...
Abstract Although the key aspects of genetic evolution and their clinical implications in clear-cell renal cell carcinoma (ccRCC) are well documented, how features coevolve with phenotype tumor microenvironment (TME) remains elusive. Here, through joint genomic–transcriptomic analysis 243 samples from 79 patients recruited to TRACERx Renal study, we identify pervasive nongenetic intratumor heterogeneity, over 40% not attributable alterations. By integrating transcriptomes phylogenetic...
Despite the importance of microRNAs (miRs) for regulation delicate balance between cell proliferation and death, evidence their specific involvement during death receptor (DR)-mediated apoptosis is scarce. Transfection with miR-133b rendered resistant HeLa cells sensitive to tumor necrosis factor-alpha (TNFα)-induced death. Similarly, caused exacerbated proapoptotic responses TNF-related apoptosis-inducing ligand (TRAIL) or an activating antibody Fas/CD95. Comprehensive analysis,...
microRNAs (miRNAs) are small molecules that regulate gene expression posttranscriptionally. In a previous study, we identified miR-96 to be upregulated in prostate cancer specimens comparison normal adjacent tissue and an independent marker of biochemical relapse multivariate prediction model. Therefore, investigated the functional role carcinogenesis. LNCaP DU145 cells were transiently transfected with precursors phenotypic changes analyzed. The increased proliferation impaired apoptosis...
Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias is inherent in current methodologies. This caused by tissue sample input fixed dimensions (e.g., 6 mm biopsy), which becomes grossly under-powered as tumor volume scales. Here, we demonstrate representative sequencing (Rep-Seq) new method achieve unbiased sampling. Rep-Seq uses residual material, homogenized and subjected next-generation sequencing. Analysis intratumor mutation burden (TMB)...
Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and severe disease. In the context CAPTURE study (NCT03226886), we report in 80 patients who received fourth dose BNT162b2. We measured neutralizing antibody titers (NAbTs) using live virus microneutralization assay against wild-type (WT), Delta, Omicron BA.1 BA.2 T cell WT an activation-induced marker (AIM) assay. The proportion detectable NAb after increased...
Prostate-specific antigen testing has led to overtreatment of prostate cancer (PCa). Only a small subset PCa patients will have an aggressive disease that requires intensive therapy, and there is currently no biomarker predict aggressiveness at the time surgery. MicroRNAs (miRNAs) are reported be involved in pathogenesis.This study 105 participants. For discovery phase, prostatectomy samples were dichotomized high-risk (n = 27, biochemical failure <36 months after prostatectomy) low-risk...
Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal carcinoma (ccRCC) has yet to be conducted. Therefore, the objective this study was identify and validate ccRCC tissue with focus evaluate their potential prognostic A identification total RNA extracted from samples performed using microarray analysis. Three relevant differentially expressed were selected (circEGLN3, circNOX4, circRHOBTB3), circular nature...