Catherine Horsfield
A5040432302- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Mycobacterium research and diagnosis
- Complement system in diseases
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Infectious Diseases and Mycology
- Urologic and reproductive health conditions
- Testicular diseases and treatments
- Cancer Genomics and Diagnostics
- Cell Image Analysis Techniques
- Vasculitis and related conditions
- Tuberculosis Research and Epidemiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatic function and diabetes
- AI in cancer detection
- Systemic Lupus Erythematosus Research
- Sperm and Testicular Function
- Renal and related cancers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
Guy's and St Thomas' NHS Foundation Trust
2013-2024
St Thomas' Hospital
2005-2023
National Health Service
2006-2022
Guy's Hospital
2007-2021
Genomics England
2020
RELX Group (United States)
2020
St. Thomas Hospital
2018
King's College London
2015-2016
Thomas Foundation
2006-2016
Cancer Clinic
2011
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. observe up 30 driver events per and show that subclonal diversification is associated with known prognostic parameters. By resolving patterns event ordering, co-occurrence, mutual exclusivity at clone level, we deterministic nature clonal evolution. ccRCC...
Highlights•Anti-CTLA-4 of hIgG1 and hIgG2 isotypes promote depletion intra-tumoral Treg cells•hIgG2 antibodies mediate in vivo cells via CD32a•Anti-CTLA-4 with enhanced Fc effector function improves therapeutic outcomes•The CD16-V158F SNP is associated response to ipilimumab inflamed tumorsSummaryWith the use a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that equivalent tremelimumab regulatory T (Treg) cell vivo, increasing CD8+ ratio promoting tumor rejection....
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect including around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey, agreement...
Mycobacterium ulcerans disease is common in some humid tropical areas, particularly parts of West Africa, and current management by surgical excision skin lesions ranging from early nodules to extensive ulcers (Buruli ulcer). Antibiotic therapy would be more accessible patients areas Buruli ulcer endemicity. We report a study the efficacy antibiotics converting (nodules plaques) culture positive negative. Lesions were excised either immediately or after treatment with rifampin orally at 10...
The complement system has a critical role in both the innate and adaptive immune responses. In humans, C3 exists as two main allotypes, F (fast) S (slow), which are known to affect incidence of inflammatory disease. We conducted study address influence these alleles on late renal-graft outcome.
Abstract Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes 31 pRCCs, in four tumours, multi-region sequencing undertaken. We identify BAP1 , SETD2 ARID2 Nrf2 pathway genes ( KEAP1 NHE2L2 CUL3 ) as probable drivers, together at least eight other possible drivers. However, only ~10% tumours harbour detectable pathogenic changes any one...
Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant dynamics remain limited. We investigated spatial and temporal features diversification in clear cell renal carcinoma through a combination modelling real tumour analysis. observe that the mode growth, surface or volume, impacts extent subclonal diversification, enabling interpretation diversity patient tumours. Specific patterns proliferation necrosis explain expansion emergence parallel...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to key focus on impact microvascular inflammation and biopsy-based transcript analysis Classification, further sessions were devoted other aspects kidney transplant pathology, particular T cell-mediated rejection, activity chronicity indices, digital xenotransplantation, clinical trials, surrogate...
The pathogenesis and natural history of HIV-associated immune complex kidney disease (HIVICK) is not well understood. Key questions remain unanswered, including the role HIV infection replication in development efficacy antiretroviral therapy (ART) prevention treatment disease. In this multicentre study, we describe renal pathology HIVICK compare clinical characteristics patients with those IgA nephropathy (HIVAN). Poisson regression models were used to identify risk factors for each these...
ABSTRACT Punch biopsy specimens from Mycobacterium ulcerans disease lesions were used to compare the sensitivities and specificities of direct smear, culture, PCR, histopathology in making a diagnosis M. field setting. PCR for insertion element IS 2404 was modified include uracil- N -glycosylase deoxyuridine triphosphate instead deoxythymidine reduce risk cross contamination. The “gold standard” confirmation clinically diagnosed Buruli ulcer definite histological diagnosis, positive culture...
This study examined the clinical indications and timing for native nephrectomy (NN), together with associated pathological findings in transplant patients autosomal dominant polycystic kidney disease (ADPKD) at our institute over a period of 20 years.A retrospective review was performed ADPKD who had undergone both transplantation NN. Patients were identified from database between 1988 2008 Guy's St Thomas' Hospital notes reviewed. All NN specimens re-reviewed reported according to current...
In Brief Background A significant proportion of procured deceased donor kidneys are subsequently discarded. The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012, enabling at risk discard to be simultaneously offered participating centers. We undertook an analysis discarded determine if unnecessary organ still occurring since the KFTS introduced. Methods Between April and June 2015, senior surgeons independently inspected 31 consecutive from throughout United Kingdom. All were...
The complement system plays a pivotal role in the pathogenesis of ischemia-reperfusion injury solid organ transplantation. Mirococept is potent membrane-localizing inhibitor that can be administered ex vivo to donor kidney prior To evaluate efficacy reducing delayed graft function (DGF) deceased renal transplantation, we undertook mirococept (APT070) for preventing ischaemia-reperfusion allograft (EMPIRIKAL) trial (ISRCTN49958194). A dose range 5-25 mg would tested, starting with 10 cohort...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect Classification - around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey,...
Abstract The distribution of M. ulcerans in Buruli ulcer lesions was analysed by IS 2404 real‐time PCR quantification DNA and semi‐quantitative microscopic assessment the number acid‐fast bacilli (AFB). Mycobacterial burden compared with histopathological changes. Focal tissue destruction extending into areas high low mycobacterial a feature all analysed. Even where most mycobacteria were washed out ulcerative lesions, peaks AFB necrotic base ulcers still marked position primary infection...
The Banff pancreas working schema for diagnosis and grading of rejection is widely used treatment guidance risk stratification in centers that perform allograft biopsies. Since the last update, various studies have provided additional insight regarding application enhanced our understanding clinicopathologic entities. This update aims to clarify terminology lesion description T cell-mediated antibody-mediated rejections, both active chronic forms. In addition, morphologic immunohistochemical...
RituxiCAN-C4 combined an open-labelled randomised controlled trial (RCT) in 7 UK centres to assess whether rituximab could stabilise kidney function patients with chronic rejection, exploratory analysis of how B cell-depletion influenced T cell anti-donor responses relative outcome. Between January 2007 and March 2015, 59 recruits were enrolled after screening, 23 whom consented the embedded RCT. Recruitment was halted when a pre-specified per protocol interim analysis, RCT discovered be...
ABSTRACT Mycobacterium ulcerans disease (Buruli ulcer) is a skin-ulcerating infection common in some parts of the tropics. We have investigated cytokine secretion after stimulation whole blood from Buruli ulcer (BU) patients region endemicity Ghana with M. sonicate or culture filtrate antigens to investigate development response over time and its specificity by comparison tuberculosis human immunodeficiency virus-negative patients. Significant gamma interferon (IFN-γ) production whole-blood...
Objectives To determine the frequency of spermatogenesis in patients with testicular cancer and to assess for any predictors spermatogenesis. Patients Methods We retrospectively reviewed 103 germ cell tumours ( TGCT s) men who underwent radical orchidectomy conducted at Guy's Hospital, London, between 2011 2015. Primary outcome measures included: presence characteristics (widespread/focal/proximity tumour). Secondary microlithiasis, tumour (size, stage, type), markers. as potential were...
Background and objectives For many women pregnancy is the first contact with health services, thus providing an opportunity to identify renal disease. This study compares causes long-term outcomes of biopsy-proven disease identified during or within 1 year postpartum, nonpregnant women. Design, setting, participants, & measurements Native biopsies (1997–2012), in childbearing age (16 <50 years), from 21 hospitals were studied. The pregnancy-related diagnosis group included those...
ABSTRACT Cytokine mRNA expression in biopsies of Mycobacterium ulcerans -infected human tissue was investigated using real-time PCR, and the findings were correlated with clinical stages disease histopathologies. A broad range cytokine mRNAs detected 16 early nodules 28 late-stage ulcers, including those for Th1 cytokines tumor necrosis factor alpha (TNF-α) gamma interferon (IFN-γ) Th2 interleukin 10 (IL-10). IFN-γ strongly expressed both suggesting that a response begins disease. There...