A5042238057- Renal Transplantation Outcomes and Treatments
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Biomedical Text Mining and Ontologies
- Organ Transplantation Techniques and Outcomes
- Emergency and Acute Care Studies
- Renal Diseases and Glomerulopathies
- Nephrotoxicity and Medicinal Plants
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- COVID-19 and healthcare impacts
- Cytomegalovirus and herpesvirus research
- Genomic variations and chromosomal abnormalities
- COVID-19 Clinical Research Studies
- Electronic Health Records Systems
- Sepsis Diagnosis and Treatment
- Medical Coding and Health Information
- Organ Donation and Transplantation
- Data-Driven Disease Surveillance
- Topic Modeling
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Neurological Complications and Syndromes
- Prenatal Screening and Diagnostics
- Chronic Disease Management Strategies
University Hospitals Birmingham NHS Foundation Trust
2016-2024
Health Data Research UK
2020-2023
University of Birmingham
2013-2023
Queen Elizabeth Hospital Birmingham
2012-2022
Queen Elizabeth Hospital
2020-2022
Chelsea and Westminster Hospital
2022
NIHR Surgical Reconstruction and Microbiology Research Centre
2010-2021
Birkbeck, University of London
2019
Barking, Havering And Redbridge University Hospitals NHS Trust
2019
British Renal Society
2015-2016
Degenerative disorders of motor neurons include a range progressive fatal diseases such as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal (SMA). Although the causative genetic alterations are known for some cases, molecular basis many SMA SBMA-like syndromes most ALS cases is unknown. Here we show that missense point mutations in cytoplasmic dynein heavy chain result neuron degeneration heterozygous mice, homozygotes this accompanied by formation...
Abstract Background The National Early Warning Score (NEWS2) is currently recommended in the UK for risk stratification of COVID-19 patients, but little known about its ability to detect severe cases. We aimed evaluate NEWS2 prediction outcome and identify validate a set blood physiological parameters routinely collected at hospital admission improve upon use alone medium-term stratification. Methods Training cohorts comprised 1276 patients admitted King’s College Hospital Health Service...
Globally, there is a paucity of multimorbidity and comorbidity data, especially for minority ethnic groups younger people. We estimated the frequency common disease combinations identified non-random associations all ages in multiethnic population.In this population-based study, we examined patterns stratified by ethnicity or race, sex, age 308 health conditions using electronic records from individuals included on Clinical Practice Research Datalink linked with Hospital Episode Statistics...
ABSTRACT Alpha/beta interferon (IFN-α/β) is a key mediator of innate antiviral responses but has little effect on the established replication dengue viruses, which are mosquito-borne flaviviruses immense global health importance. Understanding how IFN system inhibited in virus-infected cells would provide critical insights into disease pathogenesis. In recent study analyzing ability individual virus-encoded proteins to antagonize response, nonstructural (NS) protein 4B and possibly NS2A NS4A...
The X chromosome-linked scurfy (sf) mutant of the mouse is recognized by scaliness skin from which name derived and results in death affected males at about 3-4 weeks age. Consideration known man-mouse homologies chromosome prompted hematological studies, have shown that blood highly abnormal. platelet erythrocyte counts are both reduced become progressively lower relative to normal as disease progresses. There gastrointestinal bleeding, most animals appear die severe anemia. By contrast,...
Simultaneous 24-hour intragastric acidity and plasma gastrin concentrations were measured in 12 duodenal ulcer patients before on the twenty-eighth day of treatment with either ranitidine 150 mg b.d. or omeprazole 20 o.m. Median integrated was decreased significantly from 1148 to 490 36 mmol.hour litre-1 during omeprazole, respectively, whilst median raised 328 799 1519 pmol.hour respectively. When results all 48 experiments considered together, there a significant inverse correlation...
To monitor hospital activity for presentation, diagnosis and treatment of cardiovascular diseases during the COVID-19) pandemic to inform on indirect effects.
T cell immunity is essential for the control of cytomegalovirus (CMV) infection after transplantation. We evaluated a CMV-specific peptide-based enzyme-linked immunosorbent spot (ELISPOT) assay to determine whether results could predict subsequent CMV events. Adult kidney transplant recipients at 43 centers underwent ELISPOT testing enumerate interferon gamma (IFN-γ) binding spot-forming units (sfu) stimulation cells with an overlapping peptide pool phosphoprotein 65 (pp65) and immediate...
Recent cross-sectional studies suggest an important role for transitional B lymphocytes (CD19 + CD24hiCD38hi) in promoting transplant tolerance, and protecting from late antibody-mediated rejection (ABMR). However, prospective are lacking. This study enrolled 73 de novo recipients, collected serial clinical, immunological biochemical information over 48 ± 6 months. Cell phenotyping was conducted immediately prior to transplantation, then on five occasions during the first year...
Background Studies suggest that certain black and Asian minority ethnic groups experience poorer outcomes from COVID-19, but these studies have not provided insight into potential reasons for this. We hypothesised would be those of South ethnicity hospitalised a confirmed SARS-CoV-2 infection, once confounding factors, health-seeking behaviours community demographics were considered, this might reflect more aggressive disease course in patients. Methods Patients with infection requiring...
The Gnas locus in distal mouse chromosome (Chr) 2 is emerging as a complex genomic region. It contains three imprinted genes the order Nesp - Gnasxl Gnas. encodes G protein α-subunit, and encode proteins of unknown function expressed neuroendocrine tissue. Together, these form single transcription unit because transcripts are alternatively spliced onto exon from opposite parental alleles, with encoding maternal-specific transcript paternal-specific transcript. We now identify further this...
There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action poorly understood. Within the Gnas cluster on mouse chromosome 2, Nespas a paternally expressed macroRNA arises from an imprinting control region and runs antisense to Nesp, repressed protein coding transcript. Here we report knock-in allele behaves as hypomorph. The hypomorph mediates down-regulation Nesp in cis through chromatin modification at promoter...
<h2>Summary</h2><h3>Background</h3> Whole-body MRI (WB-MRI) could be an alternative to multimodality staging of colorectal cancer, but its diagnostic accuracy, effect on times, number tests needed, cost, and treatment decisions are unknown. We aimed prospectively compare the accuracy efficiency WB-MRI-based pathways with standard in cancer. <h3>Methods</h3> The Streamline C trial was a prospective, multicentre done 16 hospitals England. Eligible patients were 18 years or older, newly...
<h2>Summary</h2><h3>Background</h3> Whole-body magnetic resonance imaging (WB-MRI) could be an alternative to multi-modality staging of non-small-cell lung cancer (NSCLC), but its diagnostic accuracy, effect on times, number tests needed, cost, and treatment decisions are unknown. We aimed prospectively compare the accuracy efficiency WB-MRI-based pathways with standard in NSCLC. <h3>Methods</h3> The Streamline L trial was a prospective, multicentre done 16 hospitals England. Eligible...
Twenty-four-hour intragastric acidity and plasma gastrin concentration were measured in healthy subjects (n = 16), patients with duodenal 12) or gastric 10) ulceration, pernicious anaemia 8). Median integrated 24-hour was highest ulcer lowest (1148 0 mmol.hour litre-1, respectively). the (9886 238 pmol.hour Pernicious have unremitting hypergastrinaemia throughout 24 hours. The results of this study not only provide a reference range health disease, but also will act as baseline for future...
The impact of variation within genes responsible for the disposition and metabolism calcineurin inhibitors (CNIs) on clinical outcomes in kidney transplantation is not well understood. Furthermore, potential influence donor, rather than recipient, genotypes endpoints unknown. Here, we investigated associations between donor recipient gene variants with outcome among 4471 white, CNI-treated transplant recipients. We tested 52 single-nucleotide polymorphisms (SNPs) across five genes: CYP3A4,...