A5012161690- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Photoacoustic and Ultrasonic Imaging
- Polyomavirus and related diseases
- Pediatric Urology and Nephrology Studies
- Tissue Engineering and Regenerative Medicine
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Mechanical Circulatory Support Devices
- Liver Disease Diagnosis and Treatment
- Xenotransplantation and immune response
- Sarcoma Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Thermography and Photoacoustic Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Additive Manufacturing Materials and Processes
- Diagnosis and treatment of tuberculosis
- Cardiac Ischemia and Reperfusion
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrest and Resuscitation
University of Alberta
2016-2025
Centre Hospitalier Universitaire de Lille
2024
Centre Hospitalier de Valenciennes
2024
Oregon State University
2023
University of Alberta Hospital
2013-2023
University of Ottawa
2023
University of Minnesota Rochester
2015-2022
Marmara University
2022
Health Sciences Centre
2022
MSD K.K. (Japan)
2021-2022
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of American Society Histocompatibility and Immunogenetics Pittsburgh, PA (USA) focused on refining recent updates to classification, advances from working groups, standardization molecular diagnostics. This report kidney transplant details clarifications refinements criteria chronic active (CA) T cell–mediated rejection (TCMR), borderline, antibody-mediated (ABMR). main focus sessions how address...
This meeting report from the XV Banff conference describes creation of a multiorgan transplant gene panel by Molecular Diagnostics Working Group (MDWG). Human Organ Transplant (B-HOT) is culmination previous work MDWG to identify broadly useful based on whole transcriptome technology. A data-driven process distilled list peer-reviewed comprehensive microarray studies that discovered and validated their use in kidney, liver, heart, lung biopsies. These were supplemented genes define relevant...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect including around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey, agreement...
The goal of oncologic surgeries is complete tumor resection, yet positive margins are frequently found postoperatively using gold standard H&E-stained histology methods. Frozen section analysis sometimes performed for rapid intraoperative margin evaluation, albeit with known inaccuracies. Here, we introduce a label-free histological imaging method based on an ultraviolet photoacoustic remote sensing and scattering microscope, combined unsupervised deep learning cycle-consistent generative...
Prostate-specific membrane antigen (PSMA) demonstrates overexpression in prostate cancer and correlates with tumor aggressiveness. PSMA positron emission tomography (PET) is superior to conventional imaging for the metastatic staging of per current research but studies second-generation PET radioligands locoregional are limited.
Histopathologic diagnoses in transplantation can be improved with molecular testing. Preferably, diagnostics should fit into standard-of-care workflows for transplant biopsies, that is, formalin-fixed paraffin-embedded (FFPE) processing. The NanoString(®) gene expression platform has recently been shown to work FFPE samples. We aimed evaluate its methodological robustness and feasibility studies human renal allograft A literature-derived antibody-mediated rejection (ABMR) 34-gene set,...
To compare coronavirus disease 2019 (COVID-19) acute kidney injury (AKI) to sepsis-AKI (S-AKI). The morphology and transcriptomic proteomic characteristics of autopsy kidneys were analyzed.Individuals 18 years age older who died from COVID-19 had an performed at Mayo Clinic between April 2020 October included. Morphological evaluation the 17 individuals with was performed. In a subset seven cases postmortem interval less than or equal 20 hours, ultrastructural molecular (targeted...
The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on multiple aspects antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches AMR diagnosis, including classification, histological and immunohistochemical analysis, donor- specific antibody (DSA) characterization with their current strengths limitations were reviewed view recent research. group also discussed role tissue gene expression analysis context unmet...
Sustained, indolent immune injury of the vasculature a heart transplant limits long-term graft and recipient survival. This is mitigated by poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in embryo differentiation specialized phenotypes, associated with expression apelin. In adult, role developmental established largely unknown. We found that human minor histocompatibility–mismatched donor mouse allografts alloimmune-mediated...
Molecular testing represents a promising adjunct for the diagnosis of antibody-mediated rejection (AMR). Here, we apply novel gene expression platform in sequential formalin-fixed paraffin-embedded samples from nonhuman primate (NHP) renal transplants. We analyzed 34 previously described transcripts related to AMR humans 197 archival NHP samples, including 102 recipients that developed chronic AMR, 80 without and 15 normal native nephrectomies. Three endothelial genes (VWF, DARC, CAV1),...
Novel tools are needed to improve diagnostic accuracy and risk prediction in BK virus nephropathy (BKVN). We assessed the utility of intragraft gene expression testing for these purposes. Eight hundred genes were measured 110 archival samples, including a discovery cohort native kidney BKVN (n = 5) vs pure T cell-mediated rejection (TCMR; n 10). Five polyomavirus seven immune-related (five associated with two TCMR) significantly differentially expressed between entities (FDR < 0.05). These...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark 30th anniversary first Classification, pre-meeting discussions were on past, present, and future Classification. This report is summary highlights that most important terms their effect Classification - around microvascular inflammation biopsy-based transcript analysis diagnosis. In post-meeting survey,...
Malignancies and other diseases may spread by multiple pathways, including direct extension, hematogenous spread, or via lymphatic vessels. A less-well-understood route is the peripheral nervous system, which known as perineural (PNS). In addition to accounting for pain neurologic symptoms, PNS affects both disease prognosis management. Although commonly discussed in relation head neck tumors, there emerging data regarding abdominopelvic malignancies conditions such endometriosis. Due...
Ex-situ heart perfusion (ESHP) has been proposed as an optimal method for preserving donated hearts prior to transplantation. Hypothermic oxygenated (HOP) is a simple from device design perspective, with enhanced safety compared normothermic in the event of failure. However, temperature cardiac HOP yet be determined. We evaluated effectiveness 12-hour using University Wisconsin Machine Perfusion Solution (UWMPS) different temperatures static cold storage (SCS) 6 hours followed by simulated...
<title>Abstract</title> Core needle biopsy is the gold standard procedure for sampling tissues pathology-based diagnostics. However, it produces significant tissue damage and may lead to undue pain risk of complications such as infections. Alternatives fine aspiration liquid have not yet achieved same widespread utility owing limited abundance cells relevant biomarkers in extracted sample. Here we introduce a novel shock-scattering micro-histotripsy-aided technology which uses cavitation...
Precise diagnosis of antibody-mediated rejection (AMR) in cardiac allograft endomyocardial biopsies (EMBs) remains challenging. This study assessed molecular diagnostics human EMBs with AMR. A set 34 endothelial, natural killer cell and inflammatory genes was quantified 106 formalin-fixed, paraffin-embedded classified according to 2013 International Society for Heart Lung Transplantation (ISHLT) criteria. The gene expression compared between ISHLT diagnoses correlated donor-specific antibody...