A5062514406- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Chronic Lymphocytic Leukemia Research
- Autoimmune Bullous Skin Diseases
- Multiple Myeloma Research and Treatments
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Organ Donation and Transplantation
- Systemic Sclerosis and Related Diseases
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Birth, Development, and Health
- Neuroendocrine Tumor Research Advances
- Sarcoidosis and Beryllium Toxicity Research
- Transplantation: Methods and Outcomes
- Lymphoma Diagnosis and Treatment
- Ovarian function and disorders
- Cancer and Skin Lesions
- Lung Cancer Research Studies
- Chronic Kidney Disease and Diabetes
University of Turin
2016-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2014-2024
Fondazione Ricerca Molinette
2019-2024
Ospedale San Giovanni Bosco
2021
Piedmont Reference Center for Epidemiology and Cancer Prevention
2020-2021
Metabolism and Renal Physiology
2018
Creative Research Enterprises (United States)
2018
Candiolo Cancer Institute
2016
Andover Eye Associates
2014
University of Genoa
1989-2007
Podocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy (DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants DN. However, the underlying mechanisms podocyte remain poorly understood. The cytosolic protein TNFAIP2/M-Sec required for tunneling nanotubes (TNTs) formation, which membrane channels that transiently connect cells, allowing organelle transfer. Podocytes express TNFAIP2 form TNTs, but potential relevance TNFAIP2-TNT...
Chronic active antibody-mediated rejection (cAMR) is a major determinant of late allograft failure. Rituximab/immunoglobulins (IVIg) + plasma exchange (PLEX) showed controversial results in cAMR treatment. Tocilizumab (TCZ), humanized anti-interleukin 6 receptor antibody, has been recently used as rescue therapy patients non-responsive to rituximab/IVIg/PLEX with favorable outcomes. Whether TCZ acts "per se" or requires priming effect from previous treatments currently unknown.Fifteen were...
Nephritis is a common manifestation of IgA vasculitis and morphologically indistinguishable from nephropathy. While MEST-C scores are predictive kidney outcomes in nephropathy, their value nephritis has not been investigated large multiethnic cohorts.
The pediatric International IgA Nephropathy (IgAN) Prediction Tool comprises two models with and without ethnicity is the first method to predict risk of a 30% decline in estimated glomerular filtration rate (eGFR) or kidney failure children at time biopsy using clinical factors Oxford MEST histology scores. However, it unknown if can be applied after period observation post-biopsy. Using an international multi-ethnic cohort 947 IgAN, 38% whom were followed into adulthood, was updated for...
The recurrence of primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation is associated with a high graft loss rate standard treatments based on plasmapheresis with/without rituximab. We present 2 consecutive cases nongenetic early severe recurrent FSGS refractory to rituximab and anti-interleukin 1 treatment partial response plasmapheresis. Case was 22-year-old man who rescue-treated for 36 weeks obinutuzumab (1000 mg/1.73 m
The onset of coronavirus disease (COVID-19) as a pandemic infection, has led to increasing insights on its pathophysiology and clinical features being revealed, such noticeable kidney involvement. In this study, we describe the histopathological, immunofluorescence, ultrastructural biopsy-proven injury observed in series SARS-CoV-2 positive cases our institution from April 2020 November 2021. We retrieved retrospectively reviewed nine (two pediatric seven adults) that experienced nephrotic...
PURPOSE: Tamoxifen administered at 20 mg/d has been shown to decrease breast cancer incidence in at-risk women by 50%, but toxicity may limit its broad use, particularly postmenopausal women. Because be dose-dependent, we studied the biologic activity of low concentrations tamoxifen determine plausibility a dose reduction. PATIENTS AND METHODS: We measured blood and main metabolites titration study 105 healthy (placebo, 10 mg on alternate days, mg/d, mg/d). Drug levels after 2 months...
Follicular fluid concentrations of growth hormone (GH), insulin-like factor-I (IGF-I), epidermal factor (EGF) and oestradiol were related to diversities in oocyte maturation fertilization among oocytes obtained for invitro (IVF). GH, IGF-I significantly correlated with increasing follicular size. Follicles immature had that lower when compared follicles intermediate mature oocytes. EGF concentration was similar all maturational stages. In fluids we found GH higher those atretic Immature...
<b><i>Background:</i></b> A beneficial effect of rituximab (RTX) on focal segmental glomerulosclerosis (FSGS) in pediatric patients or transplant recipients has been reported isolated cases. However, the use RTX adult with idiopathic FSGS needs further investigation. <b><i>Methods:</i></b> Eight who had biopsy-proven (63.9 ± 14.0, range 40-81 years, 4 women, men) major risk factors precluding corticosteroids conventional immunosuppression were...
// Giacomo Quattrocchio 1 , Antonella Barreca 2 Andrea Demarchi 3 Laura Solfietti 4 Giulietta Beltrame Roberta Fenoglio Michela Ferro Paola Mesiano Stefano Murgia Giulio Del Vecchio Carlo Massara Cristiana Rollino and Dario Roccatello 1, Nephrology Dialysis Unit, San Giovanni Bosco Hospital, University of Turin, Italy Division Pathology, Department Medical Sciences, Surgical Pathology Center Research Immunopathology Rare Diseases (CMID), Correspondence to: Quattrocchio, email:...