A5054640225- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Parathyroid Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Vasculitis and related conditions
- Pediatric Urology and Nephrology Studies
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Electrolyte and hormonal disorders
- Platelet Disorders and Treatments
- Gout, Hyperuricemia, Uric Acid
- Autoimmune Bullous Skin Diseases
- Hormonal Regulation and Hypertension
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Organ Transplantation Techniques and Outcomes
- Xenotransplantation and immune response
- Mesenchymal stem cell research
- Renal cell carcinoma treatment
Jikei University School of Medicine
2016-2025
Nara City Hospital
2019-2025
Juntendo University Urayasu Hospital
2024
Nara Medical University Hospital
2024
Kanazawa University
2024
Saitama Medical University
2024
The Jikei University Hospital
2000-2024
Ministry of Health Labour and Welfare
2021-2024
Japanese Society of Nephrology
2021-2024
Tachikawa Hospital
2024
The use of stem cells has enabled the successful generation simple organs. However, anatomically complicated organs such as kidney have proven more refractory to stem-cell-based regenerative techniques. Given limits allogenic organ transplantation, an ultimate therapeutic solution is establish self-organs from autologous and transplant them syngrafts back into donor patients. To this end, we striven in vitro factory build up complex structures adult by using a target organ. Cultivation human...
<h3>Importance</h3> Immunoglobulin A nephropathy is a major cause of end-stage renal disease worldwide; previous methods medical management, including use renin-angiotensin system inhibitors and corticosteroids, remain unproven in clinical trials. <h3>Objective</h3> To investigate the possible association between tonsillectomy outcomes patients with IgA nephropathy. <h3>Design, Setting, Participants</h3> This cohort study included 1065 enrolled 2002 2004 divided into 2 groups, those who...
Abstract Potter sequence consists of various symptoms associated with renal dysplasia. For bilateral agenesis, there is no hope survival. As a novel therapeutic approach for sequence, we develop unique “transplantation fetal kidneys from different species during the stage.” In this study, first validate using allogeneic transplantation. Fetal bladders green fluorescent protein-expressing rats (embryonic day 14.0–16.5) are subcutaneously transplanted into rat fetuses in utero 18.0–18.5)....
Abstract Fetal cell ablation models are crucial for studying congenital diseases, organ regeneration, and xenotransplantation. However, conventional knockout offer limited control over disease severity, while conditional often require fetus-harming inducers. In the present study, we demonstrate that inducible caspase 9 system enables precise targeting of fetal nephron progenitor cells in mice through intrinsic apoptotic pathway. Using a safe, placenta-permeable inducer, this facilitates...
Glomerular mesangial cells express matrix metalloproteinase-9 (MMP-9) in response to the proinflammatory cytokine interleukin-1 beta (IL-1 beta). To elucidate signal transduction systems involved, we focused on role of nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1), since 5'-flanking region MMP-9 gene contains binding sequences for these transacting molecules. In rat treated with an inhibitor NF-kappa B, pyrrolidine dithiocarbamate, induction by IL-1 was suppressed at...
Given the limits of allogenic organ transplantation, an ultimate therapeutic solution is to establish a self-organ from autologous stem cells and transplant them as syngrafts back into donor patients. It was reported previously that human mesenchymal (hMSC) are cultivated in growing rodent embryos can differentiate within spatially temporally appropriate developmental milieu, facilitating first step nephrogenesis. As another toward clinical application, system modified for progression...
Although clinical and experimental studies have long suggested a role for the renin-angiotensin system (RAS) in regulation of erythropoiesis, molecular basis this has not been well understood. We report here that transgenic mice carrying both human renin angiotensinogen genes displayed persistent erythrocytosis as hypertension. To identify receptor molecule responsible phenotype, we introduced transgenes into AT1a null background found hematocrit level compound was restored to normal level....
There have been several recent attempts to generate, de novo, a functional whole kidney from stem cells using the organogenic niche or blastocyst complementation methods. However, none of these succeeded in constructing urinary excretion pathway for cell-generated embryonic kidney. First, we transplanted metanephroi cloned pig fetuses into gilts; grew about 3 cm and produced urine, although hydronephrosis eventually was observed because lack an pathway. Second, demonstrated construction...
It has been suggested that low nephron number contributes to glomerular hypertension and hyperperfusion injury in progressive chronic kidney disease (CKD). The incidence of CKD Japan is among the highest world, but reasons remain unclear. We estimated total (glomerular) (NglomTOTAL) as well numbers nonsclerosed (NglomNSG) globally sclerosed glomeruli (NglomGSG), mean volume (VglomNSG) Japanese normotensive, hypertensive, subjects investigated associations between these parameters filtration...
Animal fetuses and embryos may have applications in the generation of human organs. Progenitor cells be an appropriate cell source for regenerative organs because their safety availability. However, derived from exogenous lineage progenitors developing animal not yet been obtained. Here, we established a combination system through which donor could precisely injected into nephrogenic zone native nephron progenitor (NPCs) eliminated time- tissue-specific manner. We successfully achieved...
Preclinical tests in animal models are key steps early drug development. Consequently, the International Society of Nephrology held a consensus meeting that connected experts global kidney community order to provide guidance on optimal management translational studies for development new drugs treat disease, entitled "TRANSFORM; TRAnslational Science FOR Medications." The covered various themes, including following: (i) selection disease model; (ii) pharmacokinetics; (iii) interventions late...
Nephritis is a common manifestation of IgA vasculitis and morphologically indistinguishable from nephropathy. While MEST-C scores are predictive kidney outcomes in nephropathy, their value nephritis has not been investigated large multiethnic cohorts.
A low total nephron number, which is associated with birth weight (LBW), may indicate increased susceptibility to early-onset renal diseases in children. However, few studies have assessed biopsy findings LBW We examined the relationship between and glomerular density (GD) and/or volume (GV) samples as a surrogate for number.Renal of children were compared those age-matched control subjects normal (NBW) who histopathologically diagnosed FSGS or minimal change nephrotic syndrome (MCNS) from...
Generating kidney organoids using human stem cells could offer promising prospects for research and therapeutic purposes. However, no cell-based strategy has generated nephrons displaying an intact three-dimensional epithelial filtering barrier. Here, we murine embryonic cells, documented that these tissues recapitulated the complex structure of glomerular slits in vivo accomplished selective filtration tubular reabsorption. Exploiting this technology, mixed amniotic fluid with mouse to...
Neural epidermal growth factor-like 1 (NELL1) is a recently described target antigen in membranous nephropathy (MN). NELL1-associated MN accounts for 1.5% to 8% of cases1-3,S1 and was reportedly associated with malignant diseases,2 lipoic acid supplementation,4 consumption traditional indigenous medicine containing mercury.5 Therefore, NELL1 may be an important secondary MN. Rheumatoid arthritis (RA) autoimmune inflammatory disease occasionally accompanied by Complications drugs, including...
Cross-communication between glomerular cells and infiltrating mononuclear plays an important role in the generation of or recovery from diseases. We found that cultured mesangial secrete a factor inhibits production proinflammatory cytokines by activated macrophages. Treatment J774.2 macrophages with conditioned media rat blunted transcriptional induction IL-1 beta, IL-6, TNF-alpha LPS. None other fibroblastic, epithelial, endothelial cell lines exhibited inhibitory effect. Media normal...