A5103907228- Sarcoma Diagnosis and Treatment
- Quinazolinone synthesis and applications
- Cardiac Ischemia and Reperfusion
- Synthesis and Characterization of Heterocyclic Compounds
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Bone Tumor Diagnosis and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cardiovascular Function and Risk Factors
- Retinal and Optic Conditions
- Cardiac electrophysiology and arrhythmias
- Musculoskeletal synovial abnormalities and treatments
- Video Coding and Compression Technologies
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Synthesis and Biological Evaluation
- Reconstructive Surgery and Microvascular Techniques
- Anesthesia and Neurotoxicity Research
- Vascular Tumors and Angiosarcomas
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Retinal and Macular Surgery
Gifu University
2013-2025
Gifu University Hospital
2024
Otsuka (Japan)
2002-2023
Otsuka Pharmaceutical (Spain)
2002-2023
Nagasaki University
2009-2020
Weatherford College
2020
Tohoku University
2018
Tokyo Metropolitan University
2018
Mansoura University
2018
Creative Commons
2017
The pharmacological profile and the acute chronic aquaretic effects of OPC-41061, a novel nonpeptide human arginine vasopressin (AVP) V2-receptor antagonist, were respectively characterized in HeLa cells expressing cloned AVP receptors conscious male rats. OPC-41061 antagonized [3H]-AVP binding to V2-receptors (Ki = 0.43 +/- 0.06 nM) more potently than 0. 78 0.08 or OPC-31260 9.42 0.90 nM). also inhibited V1a-receptors 12.3 0.8 but not V1b-receptors, indicating that was 29 times selective...
Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis, cell differentiation, and regulation immune system. Expression these is mediated by activation nuclear vitamin receptor (VDR). Previous studies have shown that a hormonally active form D, 1alpha,25-dihydroxyvitamin D3, exerts anticoagulant effects cultured monocytic cells. To clarify whether VDR plays any antithrombotic actions vivo, hemostatic/thrombogenic systems were examined normocalcemic...
A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most compounds obtained by cyclization appropriately substituted anthranilamides with acid chlorides, followed further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency presence a halogen atom is preferred for activity. Adrenalectomy does not affect...
Rationale: Multilineage-differentiating stress enduring (Muse) cells, pluripotent marker stage-specific embryonic antigen-3 + are nontumorigenic endogenous pluripotent-like stem cells obtainable from various tissues including the bone marrow. Their therapeutic efficiency has not been validated in acute myocardial infarction. Objective: The main objective of this study is to clarify intravenously infused rabbit autograft, allograft, and xenograft (human) marrow-Muse a infarction model their...
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney key surrogates progression to exist specifically clinical trials. The International Society Nephrology convened multi-stakeholder meeting develop on this topic. A core group, experienced in design, conduct, adjudication trials, developed a database 64 randomized trials the 163 included relevant failure....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT4-Oxo-1,2,3,4-tetrahydroquinazolines. I. Syntheses and pharmacological properties of 2-methyl-3-aryl-4-oxo-1,2,3,4-tetrahydroquinazolines their 1-acyl derivativesKentaro Okumura, Toyonari Oine, Yoshihisa Yamada, Goro Hayashi, Mototaka NakamaCite this: J. Med. Chem. 1968, 11, 2, 348–352Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://doi.org/10.1021/jm00308a036Request reuse...
We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in rabbit model of myocardial infarction (MI) and H9c2 rat cardiomyoblasts. Rabbits underwent 30 min coronary occlusion, followed by 2 days or wk reperfusion. Control microRNA (control group; 2.5 nmol/kg, n = 10) miR-145 (miR-145 group, encapsulated liposomes was intravenously administered immediately after the start cardiomyoblasts were transfected with miR-145. The MI size significantly smaller group than control...
Background: Metformin is a popular antidiabetic agent that also used to treat heart failure patients with type 2 diabetes mellitus. Several reports suggest metformin may have cardioprotective effects in without In the present study, we investigated possible therapeutic effect of and its underlying molecular mechanisms using δ-sarcoglycan-deficient mouse model dilated cardiomyopathy. Methods Results: Thirty-two-week-old mice exhibiting established cardiomyopathy extensive left ventricular...
Preclinical tests in animal models are key steps early drug development. Consequently, the International Society of Nephrology held a consensus meeting that connected experts global kidney community order to provide guidance on optimal management translational studies for development new drugs treat disease, entitled "TRANSFORM; TRAnslational Science FOR Medications." The covered various themes, including following: (i) selection disease model; (ii) pharmacokinetics; (iii) interventions late...
Numerous studies have demonstrated a correlation of matrix metalloproteinase (MMP) overexpression with the prognosis various kinds cancer. The current study investigated whether expression MMPs is correlated osteosarcoma. Expression levels MMP-2, -9, MT1-MMP and TIMP-2 were examined immunohistochemically in samples from 47 patients Correlation positivity staining was analyzed Kaplan-Meier method, statistically log-rank test. Co-localization determined by double fluorescence-conjugated...
Some 2-(fluoromethyl) analogues of 2-methyl-3-aryl-4-(3H)-quinazolinones have been synthesized and screened for CNS activities. It was shown that the possess in general more potent depressant activities less toxicities than their parent compounds. Of particular interest were (22, 24, 31) methaqualone 6-aminomethaqualone. Compound 24 activity toxic methaqualone. 31 exhbited central muscle relaxing markedly reduced toxicity as compared with
Background:Multilineage differentiating stress-enduring (Muse) cells are SSEA3+and CD105+double-positive pluripotent-like stem cells. We aimed to examine the mobilization of Muse into peripheral blood after acute myocardial infarction (AMI) and their effects on left ventricular (LV) function remodeling.
We investigated whether postinfarct treatment with oxytocin (OT) improves left ventricular (LV) function and remodeling via cardiac repair of myocardial ischemia-reperfusion injury.Experiments were performed 30 minutes coronary occlusion 2 or 14 days reperfusion rabbit model infarction. LV significantly improved in the OT group. The infarct size was reduced number CD31-positive microvessels increased There no Ki67-positive myocytes either expression receptor, phosphorylated (p)-Akt protein...
Objective It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake. We hypothesized that intake activates the angiotensin system prorenin-(pro)renin receptor system, damages heart at an early stage hypertension. Methods Wistar Kyoto rats (WKY) spontaneously hypertensive (SHR) received regular (normal-salt diet, 0.9%) high-salt (8.9%) chow for 6 weeks from to 12 age. The systolic blood pressure,...
Unicameral bone cyst (UBC) is the most common benign lytic lesion seen in children. The aim of this study to investigate clinical factors affecting pathological fracture and healing UBC. We retrospectively reviewed 155 UBC patients who consulted Nagoya musculoskeletal oncology group hospitals Japan. Sixty had at presentation. Of 141 with follow-up periods exceeding 6 months, 77 were followed conservatively 64 treated by surgery. risk was significantly higher humerus than other bones. In...