David C.H. Harris
A5103177147- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Immune Cell Function and Interaction
- Renal and Vascular Pathologies
- T-cell and B-cell Immunology
- Acute Kidney Injury Research
- Immune cells in cancer
- Reproductive System and Pregnancy
- Health Systems, Economic Evaluations, Quality of Life
- Central Venous Catheters and Hemodialysis
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Genetic and Kidney Cyst Diseases
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Biomedical Research and Pathophysiology
- Healthcare Systems and Reforms
- Renal function and acid-base balance
- Global Maternal and Child Health
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Eosinophilic Esophagitis
- Electrolyte and hormonal disorders
The University of Sydney
2016-2025
Westmead Hospital
2016-2025
Westmead Institute for Medical Research
2016-2025
Sydney Local Health District
2013-2024
Abbott Northwestern Hospital
2023
Waikato Hospital
2023
Westmead Institute
2006-2022
Queen Mary Hospital
2022
University of Hong Kong
2022
Minneapolis Heart Institute Foundation
2022
In clinical practice, there is considerable variation in the timing of initiation maintenance dialysis for patients with stage V chronic kidney disease, a worldwide trend toward early initiation. this study, conducted at 32 centers Australia and New Zealand, we examined whether influenced survival among disease.We randomly assigned 18 years age or older progressive disease an estimated glomerular filtration rate (GFR) between 10.0 15.0 ml per minute 1.73 m2 body-surface area (calculated use...
<h3>Importance</h3> Kidney disease is a substantial worldwide clinical and public health problem, but information about available care limited. <h3>Objective</h3> To collect on the current state of readiness, capacity, competence for delivery kidney across countries regions world. <h3>Design, Setting, Participants</h3> Questionnaire survey administered from May to September 2016 by International Society Nephrology (ISN) 130 ISN-affiliated with sampling key stakeholders (national nephrology...
Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment allopurinol can attenuate the decline estimated glomerular filtration rate (eGFR) in patients disease who at risk for is not known.
Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout world there significant variability in practice initiating dialysis. Factors such as availability resources, reasons for starting dialysis, timing initiation, patient education and preparedness, modality access, well varied "country-specific" factors significantly affect experiences outcomes. As burden end-stage kidney disease (ESKD) has increased globally, also been a growing recognition...
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. conference focused the 2012 KDIGO guideline with aim of identifying new insights into nomenclature, pathogenesis, diagnostic work-up, and, particular, therapy since guideline's publication. It was consensus group that most recommendations, particular those dealing therapy, will need to be revisited by guideline-updating Work Group. This report covers...
Abstract Objective To determine the global capacity (availability, accessibility, quality, and affordability) to deliver kidney replacement therapy (dialysis transplantation) conservative management. Design International cross sectional survey. Setting Society of Nephrology (ISN) survey 182 countries from July September 2018. Participants Key stakeholders identified by ISN’s national regional leaders. Main outcome measures Markers core components Results Responses were received 160 (87.9%)...
Two types of alternatively activated macrophages, M(2a) induced by IL-4/IL-13 and M(2c) IL-10/TGF-β, exhibit anti-inflammatory functions in vitro protect against renal injury vivo. Since their relative therapeutic efficacy is unclear, we compared the effects these two macrophage subsets murine adriamycin nephrosis. Both significantly reduced inflammation injury; however, macrophages more effectively glomerulosclerosis, tubular atrophy, interstitial expansion, proteinuria than macrophages....
Macrophages have heterogeneous phenotypes and complex functions within both innate adaptive immune responses. To date, most experimental studies been performed on macrophages derived from bone marrow, spleen peritoneum. However, differences among these particular sources remain unclear. In this study, the features of murine peritoneum were compared. We found that peritoneal (PMs) appear to be more mature than marrow (BMs) splenic (SPMs) based their morphology surface molecular...
In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss 2012 KDIGO glomerulonephritis guideline context new developments and insights that had occurred over years since its publication. During this Controversies Conference on Glomerular Diseases, group examined data disease pathogenesis, biomarkers, treatments identify areas consensus controversy. This report summarizes discussions...
The global nephrology community recognizes the need for a cohesive strategy to address growing problem of end-stage kidney disease (ESKD). In March 2018, International Society Nephrology hosted summit on integrated ESKD care, including 92 individuals from around globe with diverse expertise and professional backgrounds. attendees were 41 countries, 16 participants 11 low- lower-middle-income countries. purpose was develop strategic plan improve worldwide access by identifying prioritizing...
Cytokines play a pivotal role in synthesis and deposition of extracellular matrix chronic renal failure (CRF). The proinflammatory properties monocyte chemoattractant protein (MCP)-1 make it an ideal candidate cytokine for the production interstitial inflammation CRF. To investigate possible proteinuria inducing proximal tubular (PT) MCP-1, MCP-1 mRNA levels were measured by Northern blot reverse transcription PCR confluent monolayers PT cells primary culture media containing variety...
IL-10/TGF-β–modified macrophages, a subset of activated produce anti-inflammatory cytokines, suggesting that they may protect against inflammation-mediated injury. Here, macrophages modified ex vivo by IL-10/TGF-β (IL-10/TGF-β Μ2) significantly attenuated renal inflammation, structural injury, and functional decline in murine adriamycin nephrosis (AN). These cells deactivated effector inhibited CD4+ T cell proliferation. Μ2 expressed high levels the regulatory co-stimulatory molecule B7-H4,...
It is not known whether prevention of anemia among patients with chronic kidney disease would affect the development or progression left ventricular (LV) hypertrophy. A randomized controlled trial was performed 155 (creatinine clearance, 15 to 50 ml/min), entry hemoglobin concentrations ([Hb]) 110 120 g/L (female patients) 130 (male patients). Patients were monitored for 2 yr until they required dialysis; receive epoetin alpha as necessary maintain [Hb] between and (group A) 90 100 B)....