A5079212166- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Biomedical Research and Pathophysiology
- Folate and B Vitamins Research
- Gastric Cancer Management and Outcomes
- Magnesium in Health and Disease
- Hormonal Regulation and Hypertension
- Vasculitis and related conditions
- Genetic Syndromes and Imprinting
- Thyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Alcohol Consumption and Health Effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Intermetallics and Advanced Alloy Properties
- Cardiovascular Function and Risk Factors
- Trace Elements in Health
- Advanced Glycation End Products research
- Pancreatitis Pathology and Treatment
Showa University
2020-2025
Osaka Metropolitan University
2022-2024
Tokyo Metropolitan University
2023-2024
Showa University Hospital
2024
Osaka City University
2014-2023
National Cancer Center Hospital East
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Dalian Medical University
2022
Osaka City University Hospital
2022
Sarcopenia has become a serious disorder in modern society. Chronic kidney disease requiring dialysis and diabetes are some of the disorders that accelerate onset progression sarcopenia. We, therefore, investigated prevalence sarcopenia patients undergoing hemodialysis (HD) confirmed impact mellitus (DM) on this population. This study included 308 whose muscle strength mass had been evaluated using handgrip dual-energy X-ray absorptiometry, respectively. was defined according to criteria...
Nephritis is a common manifestation of IgA vasculitis and morphologically indistinguishable from nephropathy. While MEST-C scores are predictive kidney outcomes in nephropathy, their value nephritis has not been investigated large multiethnic cohorts.
To date, little proteomic information has been available from the glomeruli of diabetic patients, possibly due to clinical limitations renal biopsy in patients and insufficient quantities such specimens for proteome analysis. The purpose present study was identify altered protein expression profiles using formalin-fixed paraffin-embedded (FFPE) kidney tissues patients. Glomeruli were laser microdissected FFPE autopsy 10 with nephropathy non-diabetic control underwent analysis QSTAR Elite...
Hyperuricemia has been reported to affect renal hemodynamics in rat models. We evaluate the relationship between serum uric acid and intrarenal hemodynamic parameters humans, utilizing plasma clearance of para-aminohippurate (CPAH ) inulin (Cin).Renal glomerular were assessed by simultaneous measurement CPAH Cin 58 subjects. Of these, 19 subjects planned provide a kidney for transplantation; 26 had diabetes without proteinuria; 13 mild proteinuria. Renal calculated using Gomez`s formulae.Cin...
Abstract Background Inhibition of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) is a novel choice for the treatment renal anemia, and an oral HIF-PH inhibitor roxadustat was approved anemia. Roxadustat has high affinity to thyroid hormone receptor beta, which may affect homeostasis. Case presentation We present here patient undergoing hemodialysis with primary hypothyroidism receiving levothyroxine replacement, who showed decreased free thyroxine (FT4) stimulating (TSH) after starting...
Treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors may have pleiotropic and beneficial effects in terms of ameliorating risk factors for the progression autosomal dominant polycystic kidney disease (ADPKD). However, there is insufficient evidence regarding use these drugs patients ADPKD, as they were excluded from several clinical trials conducted to explore protection provided by SGLT2 inhibitors. This retrospective single-arm case series study was performed investigate...
ABSTRACT Background Fetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter levels were associated with cardiovascular disease (CVD) risk in patients chronic kidney (CKD). Extremely high CVD death advanced CKD consists high-incidental event mortality after event. To date, it unclear whether...
Low thyroid function may be associated with a reduced glomerular filtration rate (GFR) calculated on the basis of creatinine metabolism. Thyroid hormone directly affects serum in muscle and low might exert similar direct effect kidney. The goal study was to evaluate this possibility by assessment inulin-based GFR examine mechanism underlying reduction GFR.Renal hemodynamics were assessed simultaneous measurements plasma clearance para-aminohippurate (CPAH) inulin (Cin) 26 patients <1.00...
OBJECTIVE Little is known about the relationships between insulin resistance, intrarenal hemodynamics, and urinary albumin excretion (UAE) in humans with impaired fasting glucose (IFG) and/or tolerance (IGT). The aim of current study was to examine hemodynamic abnormalities, UAE subjects IFG or IGT. We hypothesized that abnormalities would be associated resistance. RESEARCH DESIGN AND METHODS Fifty-four kidney donors underwent 75-g oral inulin para-aminohippuric acid clearance testing....
Fetuin-A, a circulating glycoprotein synthesized in the liver, is involved insulin resistance and type 2 diabetes. However, regulation of fetuin-A synthesis has remained obscure. We previously reported that pioglitazone treatment significantly reduced serum levels patients with To clarify whether can directory inhibit hepatic synthesis, we investigated effects on expression both vitro vivo. Pioglitazone suppressed mRNA protein Fao hepatoma cells. Interestingly, rosiglitazone but not...
Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found be associated with loss kidney function. The goal this study was evaluate the relationship between SUA intrarenal hemodynamic parameters in healthy subjects, using plasma clearance para-aminohippurate (CPAH) inulin (Cin). Renal glomerular hemodynamics evaluated by simultaneous measurements CPAH Cin 48 subjects (54.6 ± 13.4 yr). Intrarenal parameters,...
Aim: Both oxidative stress and inflammation are involved in the pathogenesis of cardiovascular disease (CVD). The serum level derivatives reactive oxygen metabolites (d-ROMs) is a measure total amount hydroperoxides serving as marker stress. We investigated whether d-ROMs could predict clinical outcomes hemodialysis patients associations with independent inflammation, C-reactive protein (CRP).
Background and objectives Vitamin D receptor activators calcimimetics (calcium-sensing agonists) are two major options for medical treatment of secondary hyperparathyroidism. A higher serum calcification propensity (a shorter T 50 value) is a novel surrogate marker stress mortality in patients with CKD. We tested hypothesis that calcimimetic agent etelcalcetide more effective increasing value than vitamin activator maxacalcitol. Design, setting, participants, & measurements randomized,...
To evaluate the association between body mass index (BMI) and age at initiation of renal replacement therapy (RRT) patients with autosomal dominant polycystic kidney disease (ADPKD) in United States Japan, 2 populations different dietary habits BMIs. We performed a cross-sectional analysis using data from Renal Data System (USRDS) Japanese Society for Dialysis Therapy Registry (JRDR) to compare age, BMI, other clinical characteristics who initiated RRT countries January 1, 2006, December 31,...
OBJECTIVE Serum creatinine levels are lower in diabetic patients compared with their nondiabetic counterparts. Therefore, estimated glomerular filtration rate (eGFR) is higher the former than latter group. Factors associated overestimation of renal function were examined, and new formulae reflecting precise eGFR created. RESEARCH DESIGN AND METHODS Eighty subjects (age 56.5 ± 15.4 years; 35 males [43.8%]; 40 diabetes subjects) enrolled. GFR was evaluated by inulin clearance (Cin). values...
<b><i>Background/Aims:</i></b> Megalin mediates the uptake of glomerular-filtered iron in proximal tubules. Urinary full length megalin (C-megalin) excretion has been found to be increased association with megalin-mediated metabolic load endo-lysosomal system tubular epithelial cells (PTECs) residual nephrons. In present study, we investigated between urinary and C-megalin chronic kidney disease (CKD) patients, possible harmful effect renal...
To evaluate proteins associated with the development of diabetic nephropathy, a major cause end-stage renal disease, we analyzed protein expression in isolated glomeruli from spontaneous type 2 (OLETF) rats and their age-matched control littermates (LETO) early proteinuric stages nephropathy using QSTAR Elite LC-MS/MS. Among 191 218 that were altered significantly OLETF rats, twenty-four actin cytoskeleton-associated implicated formation stress fibers, impairment polymerization, intermediate...
Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of reactive oxygen species. In the present study, we investigated factors associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 ± 10.9 years; 89 males and 74 females), using newly established, highly-sensitive assay based on [13C2,15N2] xanthine liquid chromatography/triple quadrupole mass spectrometry. Plasma glucose serum uric acid levels correlated significantly positively XOR-a. multiple...