A5001730366- Lung Cancer Treatments and Mutations
- Renal Transplantation Outcomes and Treatments
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Renal and Vascular Pathologies
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Neurological Complications and Syndromes
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Chronic Kidney Disease and Diabetes
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Urinary and Genital Oncology Studies
- Polyomavirus and related diseases
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
Osaka City General Hospital
2017-2025
Osaka Prefectural Medical Center
2011-2025
Osaka Metropolitan University
2022-2025
National Hospital Organization
2023-2025
Toneyama National Hospital
2023-2025
Metropolitan University
2025
Japanese Urological Association
2024
Tokyo Metropolitan University
2022-2024
Osaka Prefecture University
2024
Osaka City University
2014-2023
Anti-CD20 antibody immunotherapy effectively treats non-Hodgkin's lymphoma and autoimmune disease. However, the cellular molecular pathways for B cell depletion remain undefined because human mechanistic studies are limited. Proposed mechanisms include antibody-, effector cell–, complement-dependent cytotoxicity, disruption of CD20 signaling pathways, induction apoptosis. To identify in vivo, a new mouse model anti-CD20 was developed using panel twelve anti–mouse monoclonal antibodies...
The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on activation and differentiation normal B cells was investigated. transgenic mice expressing LMP1 under control immunoglobulin promoter/enhancer displayed enhanced expression antigens spontaneously proliferated produced antibody. Humoral immune responses in CD40-deficient or backgrounds revealed that mimics CD40 signals to induce extrafollicular cell but, unlike CD40, blocks germinal center formation. Thus, these...
Abstract CD20 mAb-mediated B cell depletion is an effective treatment for malignancies and some autoimmune diseases. However, the full effects of on natural, primary, secondary Ab responses maintenance Ag-specific serum Ig levels are largely unknown. The relationship between memory cells, long-lived plasma humoral immunity also remains controversial. To address roles subsets in longevity responses, mature cells were depleted mice using mAb. Peritoneal reduced natural Ag-induced IgM...
Abstract Purpose: Examination of somatic epidermal growth factor receptor (EGFR) mutations is now a diagnostic routine for treatment cancer using EGFR tyrosine kinase inhibitors (EGFR-TKI). Circulating tumor DNA promising target noninvasive diagnostics. We evaluated its utility by quantitatively detecting activating and resistant mutations, which were measured with BEAMing (beads, emulsion, amplification, magnetics). Experimental Design: Twenty-three patients lung progressive disease after...
CD20 plays a role in human B cell proliferation and is an effective target for immunotherapy. In this study, mouse expression biochemistry were assessed the first time using new panel of CD20‐specific mAb, with function CD20‐deficient (CD20–/–) mice. was restricted initiated during late pre‐B development. The frequency density increased maturation bone marrow, subpopulation transitional IgMhi cells expressing higher levels than majority mature recirculating cells. Transitional T1 spleen also...
Although anti-CD20 immunotherapy effectively treats human lymphoma and autoimmune disease, the in vivo effect of on tissue B cells their subsets is generally unknown. To address this, anti-mouse CD20 mAbs were used a mouse model which extent kinetics cell depletion could be assessed vivo. mAb treatment depleted most mature within 2 days, with 95-98% bone marrow, blood, spleen, lymph nodes, gut-associated lymphoid tissues by day 7, including marginal zone follicular cells. The few spleen...
Genotyping of EGFR (epidermal growth factor receptor) mutations is indispensable for making therapeutic decisions regarding whether to use tyrosine kinase inhibitors (TKIs) lung cancer. Because some cases might pose challenges biopsy, noninvasive genotyping in circulating tumor DNA (ctDNA) would be beneficial cancer treatment.We developed a detection system ctDNA by deep sequencing plasma DNA. Mutations were searched >100 000 reads obtained from each exon region. Parameters corresponding the...
TAS-102 is a novel oral nucleoside antitumor agent that consists of trifluridine (FTD) and tipiracil hydrochloride (TPI) at molecular ratio 1:0.5, was approved in Japan March 2014 for the treatment patients with unresectable advanced or recurrent colorectal cancer refractory to standard therapies. In present study, we used xenografts assess whether efficacy could be improved by combining it bevacizumab, cetuximab panitumumab. orally administered twice day from 1 14, panitumumab were...
A macrocyclic bisBODIPY (bis(boron-dipyrromethene)) complex [1B2] with a figure-of-eight helicity was synthesized and successfully resolved. proven to be one of the most efficient red-emitting CPL (circularly polarized luminescence) fluorophores reported date (λ = 663 nm, |glum| 9 × 10(-3), ΦF 0.58).
Circulating tumour DNA (ctDNA) is an emerging field of cancer research. However, current ctDNA analysis usually restricted to one or a few mutation sites due technical limitations. In the case massively parallel sequencers, number false positives caused by high read error rate major problem. addition, final sequence reads do not represent original population global amplification step during template preparation. We established high-fidelity target sequencing system individual molecules...
The purpose of this study was to test the hypothesis that genetic backgrounds lung cancers could affect spatial distribution brain metastases.CT or MR images 200 patients with a total 1033 treatment-naive metastases from cancer were retrospectively reviewed (23 by CT and 177 MRI). All standardized human MRI atlas provided Montreal Neurological Institute 152 database. Locations, depths surface, sizes lesions after image standardization analyzed.The posterior fossa, anatomic "watershed areas,"...
Malnutrition is an important risk factor for the development of sarcopenia. Recently, phase angle (PhA) obtained from bioelectrical impedance analysis increasingly becoming known as a nutritional status marker and may be considered good indicator to identify elderly patients at In this study, we investigated prevalence sarcopenia relationship between PhA or body mass index (BMI) factors, evaluated discrimination performance these factors in 210 kidney transplant recipients. The median age...
Chemoimmunotherapy is the standard first-line therapy for patients with extensive-stage small cell lung cancer (ES-SCLC). However, whether findings from pivotal trials can be extrapolated to clinical practice setting remains unclear.To compare treatment outcome gaps following chemoimmunotherapy ES-SCLC between those who met and did not meet eligibility criteria used in previous trials.A prospective cohort study was conducted September 1, 2019, 30, 2020, at 32 hospitals Japan, least 12 months...
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized dominant phases variants concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha), 5 (Delta), 6 (Omicron BA.1/BA.2), 7 BA.5). Excess COVID-19-affected was analyzed by calculating standardized...
Although plasma concentrations of brain natriuretic peptides (BNP) increase in hemodialysis (HD) patients as well with cardiovascular diseases (CD), the clinical significance BNP HD has yet to be elucidated. In this study, we investigated pathophysiological patients.Plasma were measured 164 after and 14 healthy volunteers. 12 without CD, was also before HD. Multiple regression analysis performed determine important factors causing increased concentrations. Cardiac mortality monitored for 36...
<i>Background:</i> Cerebrovascular diseases are very common in hemodialysis (HD) patients. Silent cerebral infarction (SCI) has not been investigated HD patients although it may be a significant risk factor for cerebrovascular diseases. <i>Hypothesis:</i> Chronic renal failure an independent SCI and <i>Methods:</i> Cranial magnetic resonance imaging (MRI) was performed on 123 without symptomatic disease 52 control subjects. We the prevalence of...