A5006041066- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Folate and B Vitamins Research
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Inflammasome and immune disorders
- Cardiovascular Health and Disease Prevention
- Bone and Joint Diseases
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Conditions and Treatments
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Sarcoidosis and Beryllium Toxicity Research
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Pericarditis and Cardiac Tamponade
- Heme Oxygenase-1 and Carbon Monoxide
Tokyo Medical University
2023-2025
Riso Kagaku (Japan)
2003-2024
Saiseikai Shigaken Hospital
2008-2024
Nippon Medical School Hospital
2024
Shiga Medical Center
2018-2022
Yokohama City University
2016-2021
Cardiovascular Institute Hospital
2016-2021
Kyoto Prefectural University of Medicine
1991-2021
Kindai University
2013-2021
Kanazawa Medical University Hospital
2014-2021
Background We previously developed a surface-controlled water-dispersible form of curcumin and named it Theracurmin® (Theracurmin; Theravalues, Tokyo, Japan). The area under the blood concentration–time curve Theracurmin in humans was 27-fold higher than that powder. determined clinical effects orally administered patients with knee osteoarthritis during 8 weeks treatment. Methods Fifty Kellgren–Lawrence grade II or III who were aged more 40 years enrolled this randomized, double-blind,...
Our goal was to investigate the neonatal mortality rate and during NICU stay for extremely low birth weight infants born in Japan 2005.The Committee of Neonatal Medicine Pediatric Society retrospectively surveyed deaths hospitalized between January 1 December 31, 2005. From 297 institutions Japan, data on 3065 infants, which represented 98.4% those reported maternal health statistics 2005, were collected.The 13.0% 17.0%, respectively, lower than 17.7% 21.5% survey 2000. The rates 53.3% 67.7%...
Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging production of reactive oxygen species (ROS). This cross-sectional study examined whether uric possesses effects on oxidative stress under physiological conditions independent xanthine oxidoreductase (XOR), which is involved ROS production. Serum level was measured, while plasma XOR activity determined using our high-sensitive assay 192 participants (91 males, 101 females) who underwent health examinations were...
Background:Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to increase in superoxide reactive oxygen species. Activation XOR promotes oxidative stress-related tissue injury. We investigated associations between metabolic parameters plasma activity measured by a sensitive accurate assay using combination liquid chromatography triple quadrupole mass spectrometry detect [13C2,15N2]-uric [13C2,15N2]-xanthine as substrate.
Background: Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress patients with acute myocardial infarction (AMI). Methods Results: The aim this multi-center pilot study was investigate effect `low-dose EPO' (6,000 IU during percutaneous coronary intervention (PCI), 24 h 48 h) 35 a first ST-elevated AMI undergoing PCI who randomly assigned or placebo (saline) treatment. Neointimal volume,...
To determine whether mitral valve repair (MVR) under cardiopulmonary bypass would be an effective treatment for regurgitation in small-breed dogs.Retrospective case series.48 dogs (body weight, 1.88 to 4.65 kg [4.11 10.25 lb]; age, 5 15 years) with that underwent surgery between August 2006 and 2009.Cardiopulmonary was performed a circuit. After induction of cardiac arrest, annuloplasty performed, the chordae tendineae were replaced expanded polytetrafluoroethylene chordal prostheses....
Leukocytapheresis is an extracorporeal therapy for ulcerative colitis. However, no large-scale study on leukocytapheresis has been reported. This large-scale, prospective, observational aimed to evaluate the treatment outcomes of active colitis in clinical practice.Patients with treated using a Cellsorba E column between May 2010 and December 2012 were enrolled from 116 medical facilities Japan.A total 847 patients enrolled, 623 available efficacy analysis. Out patients, 80.3% had moderate...
Abstract Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, oxidoreductase (XOR), which can be source reactive oxygen species. Plasma XOR activity metabolic biomarker associated with obesity, hyperuricemia, liver dysfunction insulin resistance. However, it has recently been reported that in fat tissue low humans, unlike rodents, secreted from human tissue. Materials Methods The associations obesity hypoxanthine, plasma were...
Demographic changes in the United States over past 20 years (i.e., aging of baby boomers) should have led to an increase church attendance. However, attendance patterns during this period remained relatively stable. It is suggested that only possible if (1) boomers are not attending with greater frequency as they age ; (2) effects being offset by moving opposite direction (a secularization hypothesis) or (3) through a process intergenerational exchange whereby younger cohorts throughout...
Despite numerous discoveries from genetically engineered mice, relatively few have been translated to the bedside, mainly because it is difficult translate genes drugs. This investigation examines an antiviral drug, which also has action selectively inhibit type 5 adenylyl cyclase (AC5), a pharmaceutical correlate of AC5 knockout (KO) model, exhibits longevity and stress resistance. Our objective was examine extent pretreatment with this adenine 9-β-d-arabinofuranoside (Ara-A), favorably...
Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, involved an increase reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.The association between plasma activity, measured by using liquid chromatography mass spectrometry, levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4)...
Background and purpose Xanthine oxidoreductase (XOR), which catalyzes purine catabolism, has two interconvertible forms, xanthine dehydrogenase oxidase, the latter of produces superoxide during uric acid (UA) synthesis. An association between plasma XOR activity cardiovascular renal outcomes been previously suggested. We investigated potential cardiac parameters among cardiology patients. Methods results Plasma was measured by [13C2,15N2]xanthine coupled with liquid...
Patients with cerebral infarction have a high prevalence of asymptomatic coronary artery disease (CAD) and other vascular diseases, but there is lack such data for Japanese patients, so the present study investigated cardiovascular (CVD) in patients determined predictors CAD.The group comprised 104 who had no history CVD. All underwent computed tomographic angiography, systematic evaluation was done on basis presence CVD risk markers, degree atherosclerosis. Of total, 39 (37.5%) CAD, 9...
Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear. Accumulating studies also indicate that uric acid has both pro- and antioxidant properties. We postulated impairs function of glomerular podocytes, resulting in albuminuria. Hyperuricemic model was induced by oral administration 2% oxonic acid, a uricase inhibitor. Oxonic caused twofold increase serum levels at 8 weeks when compared control animals. Hyperuricemia this associated with blood...
In this study, we developed a highly sensitive assay for xanthine oxidoreductase (XOR) activity utilizing combination of [(13) C2 ,(15) N2 ]xanthine and liquid chromatography (LC)/triple quadrupole mass spectrometry (TQMS). assay, the amount ]uric acid (UA) produced by XOR was determined using LC/TQMS. For synthesized as substrate, ]UA an analytical standard, C3 N3 internal standard. The calibration curve obtained LC/TQMS under selected reaction monitoring mode evaluated, results indicated...