A5062478412- Chronic Kidney Disease and Diabetes
- Extracellular vesicles in disease
- Renal Diseases and Glomerulopathies
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Advanced Glycation End Products research
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Cannabis and Cannabinoid Research
- Dialysis and Renal Disease Management
- Pancreatic function and diabetes
- Circular RNAs in diseases
University of Turin
2018-2024
Podocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy (DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants DN. However, the underlying mechanisms podocyte remain poorly understood. The cytosolic protein TNFAIP2/M-Sec required for tunneling nanotubes (TNTs) formation, which membrane channels that transiently connect cells, allowing organelle transfer. Podocytes express TNFAIP2 form TNTs, but potential relevance TNFAIP2-TNT...
Podocyte dysfunction and loss are major determinants in the development of proteinuria. FSGS is one most common causes proteinuria, but mechanisms leading to podocyte injury or conferring protection against remain poorly understood. The cytosolic protein M-Sec has been involved formation tunneling nanotubes (TNTs), membrane channels that transiently connect cells allow intercellular organelle transfer. Whether podocytes express unknown potential relevance M-Sec-TNT system not explored.We...
Abstract Background MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory processes. Expression miR-146a-5p altered in target organs diabetic complications and deficiency has been implicated their pathogenesis. We investigated if serum levels were independently associated with micro/macrovascular type 1 diabetes (DM1). Methods A nested case–control study from the EURODIAB PCS 447 DM1 patients was performed. Cases (n = 294) had one or more diabetes, whereas controls 153) did not...
Background and Purpose The endocannabinoid (EC) system has been implicated in the pathogenesis of diabetic nephropathy (DN). We investigated effects peripheral blockade cannabinoid CB 1 receptor as an add‐on treatment to ACE‐inhibition type mice (DM) with established albuminuria. Experimental Approach Renal functional parameters (albumin excretion rate, creatinine clearance), tubular injury, renal structure, both EC levels markers podocyte dysfunction, fibrosis inflammation were studied...
Abstract Mitochondrial dysfunction plays an important role in the development of podocyte injury diabetic nephropathy (DN). Tunnelling nanotubes (TNTs) are long channels that connect cells and allow organelle exchange. Mesenchymal stromal (MSCs) can transfer mitochondria to other through M-Sec-TNTs system. However, it remains unexplored whether MSCs form heterotypic TNTs with podocytes, thereby enabling replacement diabetes-damaged mitochondria. In this study, we analysed TNT formation,...