A5088314097- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Renal Diseases and Glomerulopathies
- Heat shock proteins research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cannabis and Cannabinoid Research
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Advanced Glycation End Products research
- Birth, Development, and Health
- Diet and metabolism studies
- Nutritional Studies and Diet
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Circular RNAs in diseases
University of Turin
2016-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2020
RELX Group (United States)
2018
King's College London
1999-2005
King's College Hospital
2003
Guy's Hospital
1997-2003
IRCCS Istituto Auxologico Italiano
2003
University of Miami
2003
St James's University Hospital
2003
Henry Ford Hospital
2003
MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression target mRNAs. MiRNAs are present in body fluids remarkable stable form as packaged microvesicles endocytic origin, named exosomes. In the study, we have assessed miRNA urinary exosomes from type 1 diabetic patients with and without incipient nephropathy. Results showed that miR-130a miR-145 were enriched, while miR-155 miR-424 reduced microalbuminuria. Similarly, an animal model early...
In type 2 diabetes, prevalence of nonalbuminuric renal impairment is increasing worldwide, though its clinical significance remains unclear. This large-cohort study aimed at evaluating the association this phenotype with cardiovascular risk factors and other complications.Type diabetic patients from Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study (n = 15,773), visiting consecutively 19 hospital-based Diabetes Clinics in years 2007-2008, were examined. Serum...
Abstract Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, diabetic nephropathy (DN). Moreover, albuminuria an important feature all chronic kidney diseases (CKDs). Podocytes play a key role in maintaining permselectivity glomerular filtration barrier (GFB) injury podocyte, leading to foot process (FP) effacement podocyte loss, unifying underlying mechanism...
OBJECTIVE Cannabinoid receptor 1 (CB1) is localized in the central nervous system and peripheral tissues involved energy metabolism control. However, CB1 receptors are also expressed at low level within glomeruli, aim of this study was to investigate their potential relevance pathogenesis proteinuria experimental type diabetes. RESEARCH DESIGN AND METHODS Streptozotocin-induced diabetic mice were treated with...
OBJECTIVE The cannabinoid receptor type 2 (CB2) has protective effects in chronic degenerative diseases. Our aim was to assess the potential relevance of CB2 both human and experimental diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS expression studied kidney biopsies from patients with advanced DN, early diabetes, cultured podocytes. Levels endocannabinoids related enzymes were measured renal cortex mice. To functional role CB2, streptozotocin-induced mice treated for 14 weeks...
OBJECTIVE To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) chronic kidney disease (CKD), as assessed by both albuminuria estimated glomerular filtration (eGFR), in large cohort Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based clinics years 2007 2008 were examined. DR was dilated fundoscopy. CKD defined...
Podocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy (DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants DN. However, the underlying mechanisms podocyte remain poorly understood. The cytosolic protein TNFAIP2/M-Sec required for tunneling nanotubes (TNTs) formation, which membrane channels that transiently connect cells, allowing organelle transfer. Podocytes express TNFAIP2 form TNTs, but potential relevance TNFAIP2-TNT...
OBJECTIVE Monocyte chemoattractant protein-1 (MCP-1), a chemokine binding to the CC receptor 2 (CCR2) and promoting monocyte infiltration, has been implicated in pathogenesis of diabetic nephropathy. To assess potential relevance MCP-1/CCR2 system proteinuria, we studied vitro if MCP-1 CCR2 modulates nephrin expression cultured podocytes. Moreover, investigated vivo glomerular is altered kidney biopsies from patients with nephropathy whether lack affects proteinuria experimental diabetes....
Hemodynamic abnormalities have been implicated in the pathogenesis of increased glomerular permeability to protein diabetic and other glomerulopathies. Vascular factor (VPF) is one most powerful promoters vascular permeability. We studied effect stretch on VPF production by human mesangial cells intracellular signaling pathways involved. The application mechanical (elongation 10%) for 6 h induced a 2.4-fold increase over control mRNA level (P < 0.05). There was corresponding 3-fold 12 0....
Hemodynamic abnormalities are important in the pathogenesis of excess mesangial matrix deposition diabetic and other glomerulopathies. p38-Mitogen-activated protein (MAP) kinase, an intracellular signaling molecule, is activated glomeruli rats. We studied, human cells, effect stretch on p38 MAP kinase activation role stretch-induced fibronectin transforming growth factor-beta1 (TGF-beta1) accumulation. was by a rapid (11-fold increase at 30 min, P &lt; 0.001) sustained manner (3-fold 33...
Abstract. The antiproteinuric effect of angiotensin-converting enzyme inhibitors underscores the importance a hemodynamic injury and renin-angiotensin system in proteinuria various glomerular diseases. Vascular endothelial growth factor (VEGF), potent promoter vascular permeability, is induced mesangial cells by both mechanical stretch TGF-β1. This study investigates TGF-β blockade, angiotensin II (AngII), interaction between AngII on human cell VEGF production. Exposure to (1 μM)...
Hemodynamic abnormalities are important in the pathogenesis of glomerular damage diabetes. Glomerular macrophage infiltration driven by chemokine monocyte chemoattractant protein-1 (MCP-1) is an early event diabetic nephropathy. The thiazolidinedione rosiglitazone ameliorates albumin excretion rate patients with microalbuminuria and has anti-inflammatory properties, raising possibility a relationship between its renoprotective activity. Investigated was whether mesangial cell stretching,...