A5072250065- Diabetes Treatment and Management
- Diabetes Management and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacology and Obesity Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Adenosine and Purinergic Signaling
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Platelet Disorders and Treatments
- Dialysis and Renal Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Diseases and Treatments
- Diabetes Management and Education
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Regulation of Appetite and Obesity
Ospedale San Luigi Gonzaga
2011-2023
University of Turin
2013-2022
Sapienza University of Rome
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
University of Pisa
2022
University of Verona
2022
University of Siena
2022
University of Padua
2017-2022
University of Bari Aldo Moro
2022
Gonzaga University
2013
Objective: The influence of postprandial blood glucose on diabetes complications is intensively debated. We aimed to evaluate the predictive role both fasting and cardiovascular events in type 2 gender.
To evaluate whether postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes a long-term follow-up taking into account A1C the main risk factors.Consecutive diabetic patients (n = 505) followed up at our clinic were evaluated baseline (1995) for factors five glycemic control parameters (fasting glucose, h after breakfast, lunch, before dinner, A1C); first occurring during 14-year measured.We observed 172 (34.1% of population) 147 deaths (29.1%...
In type 2 diabetes, prevalence of nonalbuminuric renal impairment is increasing worldwide, though its clinical significance remains unclear. This large-cohort study aimed at evaluating the association this phenotype with cardiovascular risk factors and other complications.Type diabetic patients from Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study (n = 15,773), visiting consecutively 19 hospital-based Diabetes Clinics in years 2007-2008, were examined. Serum...
This study has been designed to investigate, in five non-insulin-dependent diabetic patients, the influence of physical training (1 h a day, 7 days wk for 6 wk, at 50-60% maximum oxygen uptake) on blood glucose control, tolerance, insulin secretion, and action. Physical resulted significant improvement These results suggest that short-term intense ameliorates main metabolic derangements diabetes mellitus.
To examine the association of hemoglobin (Hb) A1c variability with microvascular complications in large cohort subjects type 2 diabetes from Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study.Serial (3-5) HbA1c values collected a 2-year period before enrollment were available 8,260 9 centers (of 15,773 patients 19 centers). was measured as intraindividual SD 4.52 ± 0.76 values. Diabetic retinopathy (DR) assessed by dilated funduscopy. Chronic kidney disease (CKD)...
OBJECTIVE To evaluate the rate and determinants of concordance between advanced diabetic retinopathy (DR) chronic kidney disease (CKD), as assessed by both albuminuria estimated glomerular filtration (eGFR), in large cohort Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes (n = 15,773) visiting consecutively 19 hospital–based clinics years 2007 2008 were examined. DR was dilated fundoscopy. CKD defined...
In subjects with normal glucose tolerance (NGT) 1-hour postload plasma (1-h oral test [OGTT]) of >155 mg/dL predicts type 2 diabetes (T2DM) and is associated subclinical atherosclerosis.The purpose this study was to evaluate β-cell function, insulin resistance, cardiovascular risk profile in NGT a 1-h OGTT mg/dL.The GENFIEV (Genetics, PHYsiopathology, Evolution Type diabetes) multicenter recruiting individuals at high T2DM. A total 926 underwent 75-g for assessment C-peptide mathematical...
Abstract Background It is unclear whether insulin resistance (IR) contributes to excess mortality in patients with type 2 diabetes independent of diabetic kidney disease (DKD), which strongly associated IR and a major risk factor for cardiovascular (CVD), the main cause death these individuals. We tested this hypothesis from Renal Insufficiency And Cardiovascular Events Italian Multicentre Study. Methods This observational, prospective, cohort study enrolled 15,773 attending 19 Diabetes...
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous (HeFH) more common than HoFH, women with HeFH are diagnosed later undertreated compared to men; it unknown whether these sex differences also apply HoFH.
The aim of this study was to investigate the influence insulin on platelet function, both in vitro and vivo. For investigation, we evaluated whether affects function at a physiological hormone concentration by incubating platelet-rich plasma (PRP) fasting subjects with human regular final 40 μU/ml for 30 min; observed significant reduction sensitivity all aggregating agents employed, i.e., ADP, platelet-activating factor (PAF), epinephrine, collagen, Na+ arachidonate. To effect platelets is...
Objectives To assess the distribution of antihyperglycemic treatments according to age and renal function its relationship with cardiovascular disease in type 2 diabetes mellitus ( T2DM ). Design Cross‐sectional analysis. Setting Nineteen hospital‐based clinics 2007 2008. Participants Fifteen thousand seven hundred thirty‐three individuals from Renal Insufficiency Cardiovascular Events RIACE ) Italian Multicenter Study. Measurements Current were recorded. Estimated glomerular filtration rate...
Glucagon-like peptide 1 (GLP-1) is object of intensive investigation for not only its metabolic effects but also the protective vascular actions. Since platelets exert a primary role in pathogenesis atherosclerosis, inflammation and complications, we investigated whether GLP-1 directly influences platelet reactivity. For this purpose, from 72 healthy volunteers evaluated receptor (GLP-1R) expression 15-minute incubation with native form GLP-1(7-36), N-terminally truncated GLP-1(9-36)...
Despite the overall improvement in care, people with type 2 diabetes (T2D) experience an excess risk of end-stage kidney disease. We evaluated long-term effectiveness dapagliflozin on function and albuminuria patients T2D.
Abstract Aims The availability of novel lipid-lowering therapies (LLTs) has remarkably changed the clinical management homozygous familial hypercholesterolaemia (HoFH). impact these advances was evaluated in a cohort 139 HoFH patients followed real-world setting. Methods and results characteristics patients, along with information about LLTs low-density lipoprotein cholesterol (LDL-C) levels at baseline after median follow-up 5 years, were retrospectively retrieved from records enrolled...
The insulin-induced platelet anti-aggregating effect is attributed to a nitric oxide (NO)-mediated increase of cyclic guanosine monophosphate (cGMP). aim this work, carried out in human platelets, show whether insulin increases NO synthesis platelets and it enhances not only cGMP but also adenosine (cAMP) these cells. We observed that 1) dose-dependently production, evaluated as citrulline from L-arginine (n = 4, P 0.015); 2) cAMP: for instance, after 8 min incubation at 1,920 pmol/l, cAMP...
OBJECTIVE Previous studies in our laboratory showed that the platelet anti-aggregating effect exerted by insulin, mediated a nitric oxide (NO)-induced increase of guanosine-3′,5′-cyclic monophosphate (cGMP), is lost insulin-resistant obesity and obese NIDDM. It not clear 1) whether alterations observed NIDDM patients are attributable to obesity-related insulin resistance or diabetes per se 2) states present normal blunted response NO. This study has been conducted investigate sensitivity...
To investigate the effects of insulin on platelets in obesity and non-insulin-dependent diabetes mellitus (NIDDM)—classic insulin-resistant states—we determined ADP-induced platelet aggregation cGMP (guanosine 3',5'-cyclic monophosphate) content platelet-rich plasma obtained from nine obese subjects age-matched healthy volunteers eight NIDDM patients after a 3-min incubation with human recombinant (0, 240, 480, 960, 1,920 pmol/1). Platelet was evaluated using different ADP doses to measure...
Central obesity shows impaired platelet responses to the antiaggregating effects of nitric oxide (NO), prostacyclin, and their effectors—guanosine 3′,5′‐cyclic monophosphate (cGMP) adenosine (cAMP). The influence weight loss on these alterations is not known. To evaluate whether a diet‐induced body‐weight reduction restores sensitivity physiological agents reduces activation in subjects affected by central obesity, we studied 20 centrally obese before after 6‐month diet intervention aiming...
Previous reports have clearly indicated a significant relationship between hemoglobin (Hb) A1c change from one visit to the next and microvascular complications, especially nephropathy (albuminuria albuminuric chronic kidney disease, CKD). In contrast, data on macrovascular disease are less clear. This study was aimed at examining association of HbA1c variability with cardiovascular (CVD) in large cohort subjects type 2 diabetes Renal Insufficiency Cardiovascular Events (RIACE) Italian...