Ronen Durst
A5010326841- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Congenital heart defects research
- Cancer, Lipids, and Metabolism
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cardiac tumors and thrombi
- COVID-19 Clinical Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Viral Infections and Immunology Research
- Genetic Associations and Epidemiology
- Parathyroid Disorders and Treatments
- Cardiovascular Effects of Exercise
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
- Connective tissue disorders research
- Genetic factors in colorectal cancer
Hadassah Medical Center
2015-2024
Hebrew University of Jerusalem
2001-2024
University Medical Center
2010-2024
Magee-Womens Hospital
2021
European Atherosclerosis Society
2021
Hôpital Européen Georges-Pompidou
2021
University of Basel
2016
University of Cape Town
2016
National Health Laboratory Service
2016
Heidelberg University
2016
Abstract BACKGROUND Familial hypercholesterolemia (FH) is an autosomal-dominant disorder caused by mutations in 1 of 3 genes. In the 60% patients who are mutation negative, we have recently shown that clinical phenotype can be associated with accumulation common small-effect LDL cholesterol (LDL-C)-raising alleles use a 12–single nucleotide polymorphism (12-SNP) score. The aims study were to improve selection SNPs and replicate results additional samples. METHODS We used ROC curves determine...
Recommendations for moderate alcohol consumption remain controversial, particularly in type 2 diabetes mellitus (T2DM). Long-term randomized, controlled trials (RCTs) are lacking.To assess cardiometabolic effects of initiating intake persons with T2DM and whether the wine matters.2-year RCT (CASCADE [CArdiovaSCulAr Diabetes & Ethanol] trial). (ClinicalTrials.gov: NCT00784433).Ben-Gurion University Negev-Soroka Medical Center Nuclear Research Negev, Israel.Alcohol-abstaining adults...
Familial hypercholesterolaemia (FH) is an autosomal dominant disease of lipid metabolism, which leads to early coronary heart disease. Mutations in LDLR, APOB and PCSK9 can be detected 80% definite FH (DFH) patients. This study aimed identify novel FH-causing genetic variants patients with no detectable mutation.Exomes 125 unrelated DFH were sequenced, as part the UK10K project. First, analysis known genes identified 23 LDLR two mutations, explained causes excluded from further analysis....
The potential for global collaborations to better inform public health policy regarding major non-communicable diseases has been successfully demonstrated by several large-scale international consortia. However, the true impact of familial hypercholesterolaemia (FH), a common genetic disorder associated with premature cardiovascular disease, is yet be reliably ascertained using similar approaches. European Atherosclerosis Society FH Studies Collaboration (EAS FHSC) new initiative...
Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral surgery. MVP can cause arrhythmias, heart failure, sudden cardiac death, to date, causes of this disease are poorly understood. We now demonstrate that defects primary cilia genes their regulated pathways familial sporadic nonsyndromic cases. Our expression studies genetic ablation experiments confirmed a role regulating ECM deposition during development. Loss development resulted progressive...
BACKGROUND: Homozygous familial hypercholesterolemia is a genetic disease characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C) and risk premature cardiovascular events. The proof-of-concept study ORION-2 (A Study Inclisiran in Participants With Familial Hypercholesterolemia) showed that inclisiran, small interfering RNA prevents production the hepatic PCSK9 protein (proprotein convertase subtilisin/kexin type 9), could lead to durable reductions LDL-C when...
<h2>Summary</h2><h3>Background</h3> Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults were diagnosed before age 18 years via current diagnostic approaches, which derived from observations in adults. We aimed to characterise and adolescents heterozygous (HeFH) understand approaches the identification management inform future public health strategies. <h3>Methods</h3> For this cross-sectional study, we assessed younger...
Abstract Background and Aims Lerodalcibep, a novel small recombinant fusion protein of proprotein convertase subtilisin/kexin type 9 gene–binding domain (adnectin) human serum albumin, demonstrated highly effective low-density lipoprotein cholesterol (LDL-C) reduction with monthly 300 mg in 1.2 mL subcutaneous dosing Phase 2. In this global 3 trial, the safety efficacy lerodalcibep were evaluated heterozygous familial hypercholesterolaemia patients requiring additional LDL-C lowering....
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous (HeFH) more common than HoFH, women with HeFH are diagnosed later undertreated compared to men; it unknown whether these sex differences also apply HoFH.
A bstract : Background: Genetic variation in the alcohol dehydrogenase (ADH) enzyme is associated with an aversion to and a lower risk of alcoholism among Asians. There growing evidence functional role ADH2*2 allele alcohol‐drinking patterns Jews, who have traditionally exhibited low rates alcohol‐related problems. The mechanism by which this allelic effect mediated not yet clearly understood. This study examined on alcohol‐elimination (AER) under experimental conditions. Methods: Young...
Cannabidiol (CBD) is a major, nonpsychoactive Cannabis constituent with anti-inflammatory activity mediated by enhancing adenosine signaling. Inasmuch as receptors are promising pharmaceutical targets for ischemic heart diseases, we tested the effect of CBD on rat hearts. For in vivo studies, left anterior descending coronary artery was transiently ligated 30 min, and rats were treated 7 days (5 mg/kg ip) or vehicle. Cardiac function studied echocardiography. Infarcts examined...
Importance Nonsyndromic bicuspid aortic valve (nsBAV) is the most common congenital heart malformation. BAV has a heritable component, yet only few causative genes have been identified; understanding genetics key point in developing personalized medicine. Objective To identify new gene for nsBAV. Design, Setting, and Participants This was comprehensive, multicenter, genetic association study based on candidate prioritization familial cohort followed by rare studies replication cohorts....
A higher than normal incidence of thromboembolic events has been observed in adult patients with β‐thalassaemia major (TM) and certain haemostatic anomalies found these suggest the existence a chronic hypercoagulable state. Thalassaemic red blood cells (RBC) were demonstrated to facilitate thrombin formation due altered asymmetry membrane phospholipids enhanced exposure phosphatidylserine. Since RBC exist thalassaemia from first months life, we studied markers hypercoagulability...
CD4-positive lymphocytes, the major T-cell population in human atheroma, mainly secrete Th-1-type proinflammatory cytokines, like interferon (IFN)gamma, tumor necrosis factor (TNF)alpha, and interleukin (IL)-2, thus promoting atherogenesis. Recent data suggest that nuclear transcription factors liver X receptor-alpha receptor-beta (LXRalpha LXRbeta) limit plaque formation animal models by modulating macrophage function. Still, role of LXRs lymphocytes is currently unexplored.Human express...
Increased levels of C-peptide, a cleavage product proinsulin, circulate in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest potential causal role C-peptide atherogenesis by promoting monocyte T-lymphocyte recruitment into the vessel wall. The present study examined effect on vascular smooth muscle cells (VSMCs) proliferation evaluated intracellular signaling pathways involved. In arteriosclerotic lesions diabetic subjects, colocalized VSMCs media....