Chaim Lotan

ORCID: 0000-0002-2738-074X
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About
Contact & Profiles
Research Areas
  • Coronary Interventions and Diagnostics
  • Cardiac Imaging and Diagnostics
  • Cardiac Valve Diseases and Treatments
  • Acute Myocardial Infarction Research
  • Cardiovascular Function and Risk Factors
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Infective Endocarditis Diagnosis and Management
  • Cardiac Arrhythmias and Treatments
  • Heart Failure Treatment and Management
  • Cardiac electrophysiology and arrhythmias
  • Advanced MRI Techniques and Applications
  • Cardiac Structural Anomalies and Repair
  • Cardiac pacing and defibrillation studies
  • Cardiovascular Effects of Exercise
  • Venous Thromboembolism Diagnosis and Management
  • Atrial Fibrillation Management and Outcomes
  • Vascular Procedures and Complications
  • Peripheral Artery Disease Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cerebrovascular and Carotid Artery Diseases
  • Coronary Artery Anomalies
  • Aortic Disease and Treatment Approaches
  • Cardiac and Coronary Surgery Techniques
  • Aortic aneurysm repair treatments
  • Heart Rate Variability and Autonomic Control

Hadassah Medical Center
2015-2024

Hebrew University of Jerusalem
2006-2021

Hadassah Academic College
2009-2019

Breast Center
2018

University of Milano-Bicocca
2017

Emory University Hospital
2016

Clinique Pasteur
2014

National Heart Institute
2013

University of Padua
2012

KU Leuven
2012

We evaluated the effectiveness of early intravenous administration 750,000 units streptokinase in 53 patients with acute myocardial ischemia treated by a mobile-care unit at home (9 patients) or hospital (44 patients). Treatment was begun an average (+/- S.D.) 1.7 +/- 0.8 hours from onset pain. Non-Q-wave infarctions developed subsequently eight patients, whereas all others had typical Q-wave infarct patterns. In 81 per cent infarct-related artery patent angiography performed four to nine...

10.1056/nejm198511283132204 article EN New England Journal of Medicine 1985-11-28

The expanding indications for sirolimus-eluting stents (SES) include increasingly complex coronary lesions and populations with clinical profiles markedly different from those of early pivotal controlled studies. e-Cypher registry monitored the safety efficacy SES currently implanted worldwide in daily practice.Between April 2002 September 2005, data were collected on 15,157 patients who underwent implantation > or =1 at 279 medical centers 41 countries. An independent endpoint review...

10.1161/circulationaha.104.532242 article EN Circulation 2006-03-14

10.1016/s0002-9149(18)31266-9 article EN The American Journal of Cardiology 2018-08-01

Hypertension is highly prevalent and one of the most frequent chronic diseases worldwide.1 It has been suggested that over next two decades up to 50% adult population will be diagnosed with hypertension, according standard guideline definitions.1 Despite availability many safe effective antihypertensive drugs, control rates target blood pressure remain low.2 Approximately 5–10% all patients high are resistant drug treatment defined as >140/90 mmHg, >130–139/80–85 mmHg in diabetes mellitus or...

10.1093/eurheartj/eht154 article EN European Heart Journal 2013-04-25

Proton nuclear magnetic resonance (NMR) imaging has the potential to serially assess left ventricular (LV) volumes with optimal accuracy because it is a high-resolution, three-dimensional, noninvasive modality. Previous NMR studies LV have been suboptimal, as they used either planes aligned axes of body, which are compromised by partial volume effects, or spin-echo techniques that time-consuming acquire and analyze. Accordingly, for measurement, we developed gradient-echo (cine) strategy...

10.1161/01.cir.82.1.154 article EN Circulation 1990-07-01

Approximately 8–18% of all patients with high blood pressure (BP) are apparently resistant to drug treatment.1,2 In this situation, new strategies help reduce BP urgently needed but the complex pathophysiology hypertension makes search difficult. Not surprisingly in context, latest non-drug treatment which triggered controversy is catheter-based renal denervation (RDN).3,4 The method uses radiofrequency energy, or alternatively ultrasound chemical denervation, disrupt nerves within artery...

10.1093/eurheartj/ehv192 article EN European Heart Journal 2015-05-18

Cannabidiol (CBD) is a major, nonpsychoactive Cannabis constituent with anti-inflammatory activity mediated by enhancing adenosine signaling. Inasmuch as receptors are promising pharmaceutical targets for ischemic heart diseases, we tested the effect of CBD on rat hearts. For in vivo studies, left anterior descending coronary artery was transiently ligated 30 min, and rats were treated 7 days (5 mg/kg ip) or vehicle. Cardiac function studied echocardiography. Infarcts examined...

10.1152/ajpheart.00098.2007 article EN AJP Heart and Circulatory Physiology 2007-09-21

Background Low serum albumin is common in patients with chronic heart failure (HF). Hypothesis Albumin may have an impact on clinical outcome HF. We evaluated the effect of levels a real‐world cohort Methods All HF at health maintenance organization were followed for cardiac‐related hospitalizations and death. Results A total 5779 included study; mean follow‐up was 576 days; median 4.0 g/dL (interquartile range 3.7‐4.2), 12% had hypoalbuminemia (albumin<3.5 g/dL). associated increasing...

10.1002/clc.23153 article EN cc-by Clinical Cardiology 2019-01-14

This study assessed the performance of an automated speech analysis technology in detecting pulmonary fluid overload patients with acute decompensated heart failure (ADHF).Pulmonary edema is main cause (HF)-related hospitalizations and a key predictor poor postdischarge prognosis. Frequent monitoring often recommended, but signs decompensation are missed. Voice sound technologies have been shown to successfully identify clinical conditions that affect vocal cord vibration mechanics.Adult...

10.1016/j.jchf.2021.08.008 article EN cc-by-nc-nd JACC Heart Failure 2021-12-08

BACKGROUND Intramyocardial hemorrhage occurs frequently after reperfusion of acute myocardial infarction. However, its significance has not yet been established, mainly because the lack methods for detecting such hemorrhage. The following ex vivo study was carried out to assess potential nuclear magnetic resonance (NMR) imaging detect and quantitate postreperfusion intramyocardial METHODS AND RESULTS Sixteen adult mongrel dogs underwent 3 hours coronary occlusion followed by 1 hour...

10.1161/01.cir.86.3.1018 article EN Circulation 1992-09-01

Background: Coronary artery disease (CAD) is a highly prevalent with significant morbidity and mortality. Periodontal has been suggested to influence this associated CAD in some epidemiologic studies. However, relation still controversial. This study aimed determine the relationship between periodontal measures acute coronary syndromes (ACSs). Methods: Two hundred one patients presenting stable angina or ACS referred for angiography underwent assessment including evaluation of pathogens....

10.1902/jop.2007.060301 article EN Journal of Periodontology 2007-04-30

Smokers hospitalized with acute coronary syndrome (ACS) are at high risk for subsequent ischemic events. Nevertheless, over two-thirds of patients continue to smoke after an myocardial infarction. Bupropion hydrochloride has proven efficacy as a smoking cessation aid, but data regarding its safety and in ACS limited.In double-blind, randomized controlled trial, we compared the 8 weeks treatment bupropion slow-release (SR) or placebo smokers adjunct nurse-led hospital- telephone-based...

10.1001/archinternmed.2011.72 article EN Archives of Internal Medicine 2011-03-14
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