A5024344773- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Heart rate and cardiovascular health
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Coronary Interventions and Diagnostics
- Healthcare Systems and Public Health
- Cardiac pacing and defibrillation studies
- Air Quality and Health Impacts
Cone Health
2021-2023
Emory University
2016-2021
University of North Carolina at Chapel Hill
2015-2021
Lung Institute
2021
University of Missouri Health System
2021
University of Missouri
2021
Wesley College
2015-2019
Clinical Research Institute
2019
Emory and Henry College
2017-2019
Wake Forest University
2013-2018
Background: Limited information exists on the lifetime risk of atrial fibrillation (AF) in African Americans and by socioeconomic status. Methods: We studied 15 343 participants without AF at baseline from ARIC (Atherosclerosis Risk Communities) cohort recruited 1987 to 1989 4 communities United States when they were 45 64 years age. Participants have been followed through 2014. Incidence rates calculated dividing number new cases person-years follow-up. Lifetime was estimated a modified...
Background— It has recently been reported that atrial fibrillation (AF) is associated with an increased risk of myocardial infarction (MI). However, the mechanism underlying this association currently unknown. Further study relationship AF type MI (ST-segment–elevation [STEMI] versus non–ST-segment–elevation [NSTEMI]) might shed light on potential mechanisms. Methods and Results— We examined between incident in 14 462 participants (mean age, 54 years; 56% women; 26% blacks) from...
Objective The aim of this study was to assess the relationship between abnormally increased P‐wave terminal force in lead V 1 , an electrocardiographic (ECG) marker left atrial abnormality, and incident ischemic stroke subtypes. We hypothesized that associations would be stronger with nonlacunar stroke, given we expected abnormality reflect risk thromboembolism rather than situ cerebral small‐vessel occlusion. Methods Our cohort comprised 14,542 participants 45 64 years age prospectively...
OBJECTIVE This study examined the prognostic significance of diabetes and microvascular complications in patients with heart failure preserved ejection fraction (HFpEF). RESEARCH DESIGN AND METHODS analysis included 3,385 (mean age 69 ± 9.6 years; 49% male; 89% white) HFpEF from Treatment Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial (TOPCAT). Diabetes were ascertained by self-reported history medical record review. Microvascular neuropathy, nephropathy,...
<h3>Objective:</h3> Given that recent reports have suggested left atrial disease to be an independent risk factor for ischemic stroke, we sought examine if advanced interatrial block (aIAB) is stroke factor. <h3>Methods:</h3> We examined the association between aIAB and incident in 14,716 participants (mean age 54 ± 5.8 years; 55% female; 26% black) from Atherosclerosis Risk Communities Study (ARIC). Cases of were identified digital ECGs recorded during baseline ARIC visit (1987–1989) first...
Background: In people with atrial fibrillation (AF), periods of sinus rhythm present an opportunity to detect prothrombotic remodeling through measurement P-wave indices (PWIs)—prolonged duration, abnormal axis, advanced interatrial block, and terminal force in lead V1. We hypothesized that the addition PWIs CHA 2 DS -VASc score would improve its ability predict AF-related ischemic stroke. Methods: included 2229 participants from ARIC study (Atherosclerosis Risk Communities) 700 MESA...
Background The associations between high‐sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity progression remain unclear. We investigated whether there is an association hsTnI angiographic of CAD the predictive value level for incident cardiovascular outcomes independent severity. Methods Results In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence acute myocardial infarction, was calculated by number major arteries with...
Background Onset of postoperative atrial fibrillation ( POAF ) is a common and costly complication heart surgery despite major improvements in surgical technique quality patient care. The etiology , the ability clinicians to identify therapeutically target high‐risk patients, remains elusive. Methods Results Myocardial tissue dissected from right appendage RAA was obtained 244 patients undergoing cardiac surgery. Reactive oxygen species ROS generation multiple sources assessed this tissue,...
Several reports have demonstrated that prolongation of the QT interval is associated with sudden cardiac death (SCD). However, it unknown whether any components within are responsible for its association SCD.We examined individual QT-interval (R-wave onset to R-peak, R-peak R-wave end, ST-segment, T-wave T-peak, and T-peak end) SCD in 12 241 participants (54±5.7 years; 26% black; 55% women) from ARIC study (Atherosclerosis Risk Communities). The were measured at baseline (1987-1989) 12-lead...
Several markers detected on the routine 12-lead ECG are associated with future heart failure events. We examined whether these able to separate risk of reduced ejection fraction (HFrEF) from preserved (HFpEF).We analyzed data 6664 participants (53% female; mean age 62±10 years) MESA (Multi-Ethnic Study Atherosclerosis) who were free cardiovascular disease at baseline (2000-2002). A competing risks analysis was used compare association several predictors HFrEF and HFpEF during a median...
Background Oral anticoagulants ( OACs ) in patients with atrial fibrillation AF ), addition to reducing stroke risk, could also prevent adverse cognitive outcomes. The purpose of this study was compare the risk dementia incidence across initiating different OAC s. Methods and Results We identified nonvalvular s 2 US healthcare claim databases, MarketScan (2007–2015) Optum Clinformatics (2009–2015). Dementia, comorbidities, use medications were defined on basis inpatient outpatient claims....
Background The American Heart Association has defined metrics of ideal cardiovascular health known as Life's Simple 7 ( LS 7) to prevent disease. We examined the association between and incident atrial fibrillation AF ) in a biracial cohort middle‐ older‐aged adults without Methods Results This analysis included 13 182 ARIC (Atherosclerosis Risk Communities) study participants (mean baseline age=54±5.7 years; 56% women; 25% black) free An overall score was calculated sum component scores...
Social determinants of health are relevant to cardiovascular outcomes but have had limited examination in atrial fibrillation (AF).The purpose this study was examine the association annual household income and individuals with AF.We analysed administrative claims for AF from 2009 2015 captured by a database. We categorised estimates as <$40 000; $40-$59 999; $60-$74 $75-$99 ≥$100 000. Covariates included demographics, education, disease risk factors, comorbid conditions anticoagulation....
Although adenovirus vectors offer many advantages, it would be desirable to develop with improved expression and decreased toxicity. Toward this objective, an vector system deletion of both the El E2a regions was developed. A 5.9-kb fragment type 5 (Ad5) genome containing gene its early late promoters transfected into 293 cells. complementing cell line, designated 293-C2, expressed mRNA protein found complement defect in Ad5 viruses temperature-sensitive or mutations E2a. 1.3 kb removing...
The associations of mitral annular calcification (MAC) with atrial fibrillation (AF) risk factors and related outcomes suggest a possible association between MAC AF. aim this study was to examine the AF in racially ethnically diverse population.This analysis included 6641 participants (mean age 62 ± 10 years; 53% women; 27% Blacks; 22% Hispanics; 12% Chinese-Americans) from Multi-Ethnic Study Atherosclerosis (MESA) who were free clinical cardiovascular disease at baseline. presence defined...
Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons PAD have an increased of stroke. It is unclear if associated for AF whether this potential association explains the stroke observed in those PAD.We examined between PAD, measured by ankle-brachial index (ABI), incident stroke, separately, 6568 participants (mean age 62±10 years, 53% women, 62% nonwhite) from Multi-Ethnic Study Atherosclerosis (MESA). ABI values <1.0 or >1.4 defined PAD....