A5013636467- COVID-19 and healthcare impacts
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Acute Myocardial Infarction Research
- Cardiovascular Health and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Protease and Inhibitor Mechanisms
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Biomarkers in Disease Mechanisms
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Aortic Disease and Treatment Approaches
- Sulfur Compounds in Biology
- Cardiac pacing and defibrillation studies
Northeast Georgia Medical Center
2020-2025
The University of Texas at Dallas
2025
University of Dallas
2025
Emory University
2011-2024
Southeast Georgia Health System
2024
North Georgia Heart Foundation
2023
Emory Clinic
2014-2018
University College London
2014-2017
John Wiley & Sons (United States)
2017
Florida International University
2014-2017
Free radical scavengers have failed to improve patient outcomes, promoting the concept that clinically important oxidative stress may be mediated by alternative mechanisms. We sought examine association of emerging aminothiol markers nonfree with clinical outcomes.Plasma levels reduced (cysteine and glutathione) oxidized (cystine glutathione disulphide) aminothiols were quantified high performance liquid chromatography in 1411 patients undergoing coronary angiography (mean age 63 years, male...
Background Young women with coronary heart disease have high rates of depression and a higher risk adverse events than men similar age. Whether has prognostic value in this group older is not known. Our objective was to assess whether young associated artery ( CAD ) outcomes compared similarly aged women. Methods Results We examined 3237 patients undergoing angiography for evaluation followed them 2.9 years (median). Depressive symptoms were assessed the Patient Health Questionnaire PHQ )‐9,...
Introduction Soluble urokinase plasminogen activator receptor (suPAR) is an emerging inflammatory and immune biomarker. Whether suPAR level predicts the presence severity of coronary artery disease (CAD), incident death myocardial infarction (MI) in subjects with suspected CAD, unknown. Methods Results We measured plasma levels 3367 (67% CAD) recruited Emory Cardiovascular Biobank followed them for adverse cardiovascular (CV) outcomes MI over a mean 2.1±1.1 years. Presence angiographic CAD...
Rationale: Low circulating progenitor cell numbers and activity may reflect impaired intrinsic regenerative/reparative potential, but it remains uncertain whether this translates into a worse prognosis. Objectives: To investigate low of cells associate with greater risk mortality in population at high cardiovascular risk. Methods Results: Patients undergoing coronary angiography were recruited 2 cohorts (1, n=502 2, n=403) over separate time periods. Progenitor enumerated by flow cytometry...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein (LDL) receptor. Mutations block PCSK9 secretion reduce LDL-cholesterol and incidence myocardial infarction (MI). However, it remains unclear whether elevated plasma associates with coronary atherosclerosis (CAD) or more directly rupture plaque causing MI.Plasma was measured by ELISA in 645 angiographically defined controls (<30% stenosis) 3,273 cases CAD...
Background The associations between high‐sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity progression remain unclear. We investigated whether there is an association hsTnI angiographic of CAD the predictive value level for incident cardiovascular outcomes independent severity. Methods Results In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence acute myocardial infarction, was calculated by number major arteries with...
<i>Objective</i>. This paper illustrates the evolution of our knowledge arterial pulse from ancient times to present. Several techniques for evaluation throughout history are discussed. <i>Methods</i>. Using databases including Worldcat, Pubmed, and Emory University Libraries' Catalogue, significance is discussed in three historical eras medicine: ancient, medieval, modern. <i>Summary</i>. Techniques used over time analyze its characteristics have advanced simple by touch complex...
Significant paravalvular leak (PVL) after transcatheter aortic valve replacement (TAVR) confers a worse prognosis. Symptoms related to significant PVL may be difficult differentiate from those other causes of heart failure. Cardiovascular magnetic resonance (CMR) directly quantifies valvular regurgitation, but has not been extensively studied in symptomatic post-TAVR patients. CMR was compared qualitative (QE) and semi-quantitative echocardiography (SQE) for classifying prognostic value at...
Genetic risk scores have been developed for coronary artery disease and atherosclerosis, but are not predictive of adverse cardiovascular events. We asked whether peripheral blood expression profiles may be acute myocardial infarction (AMI) and/or death.Peripheral samples from 338 subjects aged 62 ± 11 years with (CAD) were analyzed in two phases (discovery N = 175, replication 163), followed a mean 2.4 death. Gene was measured on Illumina HT-12 microarrays different normalization procedures...
Rationale: We investigated aging of human endogenous reparative capacity and aimed to clarify whether it is affected by presence cardiovascular disease or its risk factors (RFs). Objective: Circulating progenitor cell (PC) levels reflect regenerative potential. The effect on PC healthy compared with RFs (CVD) unknown. examined exposure RF CVD leads an accelerated decline in circulating increasing age. Methods Results: In 2792 adult subjects, 498 were free (smoking, diabetes mellitus,...
Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease. However, their predictive role heart failure (HF) remains controversial. We the relationship between number PCs and pathogenesis severity HF impact on incident events.We recruited 2049 adults which 651 had diagnosis. were enumerated by flow cytometry CD45med+ blood mononuclear cells expressing CD34, CD133, vascular...
Rationale: Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Despite sharing the same risk factors, only 20% to 30% patients with coronary artery (CAD) develop PAD. Decline in number bone marrow–derived circulating progenitor cells (PCs) thought contribute pathogenesis Whether specific changes PCs differentiate both PAD and CAD from those alone unknown. Objective: Determine whether differences exist counts without known Methods Results: 1497...
Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association humans is unknown. We investigated relationship between artery systolic pressure measured by echocardiography and plasma aminothiol oxidative markers, with hypothesis that will be higher those hypertension. A group 347 patients aged 65±12 years from Emory Cardiovascular Biobank underwent echocardiographic assessment left ventricular ejection fraction pressure. Plasma...
Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes the transport of miRNA, particularly decreased miRNA enrichment microparticles (MPs). Additionally, MPs from patients were less efficient at transferring to cultured HUVECs, which correlated their diminished capacity bind developmental endothelial locus‐1 (Del‐1). In summary, distinct...