A5033876516- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Health and Disease Prevention
- Spinal Dysraphism and Malformations
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Disease and Adiposity
- Head and Neck Surgical Oncology
- Cardiac Structural Anomalies and Repair
- Spinal Fractures and Fixation Techniques
- Mesenchymal stem cell research
- Peripheral Artery Disease Management
- Neurological disorders and treatments
- Renal and Vascular Pathologies
- Spinal Cord Injury Research
- Cardiac electrophysiology and arrhythmias
Emory University
2016-2025
Georgia Institute of Technology
2016-2025
The Wallace H. Coulter Department of Biomedical Engineering
2015-2024
University of Virginia Health System
2001-2023
Centre National de la Recherche Scientifique
2023
Inserm
2023
Institut National des Sciences Appliquées de Lyon
2023
University of Missouri
2023
Emory University Hospital
1996-2015
Universidade de São Paulo
2011
Numerous criteria believed to define a positive response cardiac resynchronization therapy have been used in the literature. No study has investigated agreement among these criteria. We hypothesized that various would be poor.A literature search was conducted with keywords "cardiac resynchronization" and "response." The 50 publications most citations were reviewed. After exclusion of editorials reviews, 17 different primary identified from 26 relevant articles. 15 assessed 426 patients...
In patients with acute myocardial infarction (MI), delayed enhancement is seen in MRI 5 to 7 minutes after gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) injection, and the occurs regions that later show recovery of function. However, a canine model MI, 20 30 injection only necrotic not surrounding, reversibly injured myocardium. The objective present study was determine (1) if size enhanced region varies time Gd-DTPA (2) when corresponds true infarct size.The left coronary artery...
Purpose To validate a real‐time phase contrast magnetic resonance imaging (RT‐PCMRI) sequence in controlled phantom model, and to quantify the relative contributions of respiration cardiac pulsations on cerebrospinal fluid (CSF) velocity at level foramen magnum (FM). Materials Methods 3T MRI techniques, vitro studies used realistic model spinal subarachnoid space driven by pulsatile flow waveforms mimicking respiratory components CSF flow. Subsequently, was measured continuously during...
Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this relationship has not been examined in human atherosclerosis progression. Thus, the aim of investigation was examine association between WSS, combination with WSS magnitude, coronary We hypothesized regions will demonstrate progression towards lesions, while exposed non-oscillatory exhibit stable lesions. Patients ( n = 20)...
Helical flows have been observed in the ascending aorta vivo, and geometric curvature has suggested to be a major contributing factor. We employed magnetic resonance imaging (MRI) velocity mapping develop computational model examine effects of also wall compliance movement upon flow patterns. In model, MRI-derived geometry velocities were imposed as boundary conditions, which included both radial expansion-contraction translational motion wall. The computed results agreement with MR data...
Patient-specific computational fluid dynamics (CFD) is a powerful tool for researching the role of blood flow in disease processes. Modern clinical imaging technology such as MRI and CT can provide high resolution information about vessel geometry, but many situations, patient-specific inlet velocity not available. In these simplified profile must be selected. We studied how idealized profiles (blunt, parabolic, Womersley flow) affect CFD results when compared to simulations employing...
Abstract Purpose To evaluate the reproducibility of a new multisite axial pulse wave velocity (PWV) measurement technique that makes use 2D PCMR data and cross‐correlation analysis. Materials Methods PWV was estimated with MRI in 13 healthy volunteers by transit‐time (TT), utilizing 1D descending aorta (FOOT), uses over ascending, transverse, sections (2D‐XC). Results No significant difference observed between measurements values measured three techniques. However, 2D‐XC displayed...
Significant paravalvular leak (PVL) after transcatheter aortic valve replacement (TAVR) confers a worse prognosis. Symptoms related to significant PVL may be difficult differentiate from those other causes of heart failure. Cardiovascular magnetic resonance (CMR) directly quantifies valvular regurgitation, but has not been extensively studied in symptomatic post-TAVR patients. CMR was compared qualitative (QE) and semi-quantitative echocardiography (SQE) for classifying prognostic value at...
Chiari malformation Type I (CMI) is characterized by herniation of the cerebellar tonsils through foramen magnum. The pathophysiology CMI not well elucidated; however, prevailing theory focuses on underdevelopment posterior cranial fossa which results in tonsillar herniation. Symptoms are believed to be due causing resistance natural flow cerebrospinal fluid (CSF) and exerting a mass effect nearby neural tissue. However, asymptomatic cases vastly outnumber symptomatic ones it known why some...
Abstract Cerebrospinal fluid (CSF), a clear bathing the central nervous system (CNS), undergoes pulsatile movements. Together with interstitial fluid, CSF plays critical role for removal of waste products from brain, and maintenance CNS health. As such, understanding mechanisms driving movement is high scientific clinical impact. Since dynamics sensitive synchronous to respiratory movements, we are interested in identifying potential integrative therapies such as yogic breathing regulate...
To develop a three-dimensional (two dimensions + time) convolutional neural network trained with displacement encoding stimulated echoes (DENSE) data for and strain analysis of cine MRI.In this retrospective multicenter study, deep learning model (StrainNet) was developed to predict intramyocardial from contour motion. Patients various heart diseases healthy controls underwent cardiac MRI examinations DENSE between August 2008 January 2022. Network training inputs were time series myocardial...
This paper presents a method for 3-D deformation recovery of the left ventricular (LV) wall from anatomical cine magnetic resonance imaging (MRI). The is based on deformable model that incompressible, desired property since myocardium has been shown to be nearly incompressible. LV needs segmented in an initial frame after which automatically determines everywhere throughout cardiac cycle. Two studies were conducted validate method. In first study, recovered MRI healthy volunteer was compared...
Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by formation cystic cavity (syrinx) in spinal cord (SC), has not yet been provided. It hypothesized that abnormal cerebrospinal fluid (CSF) pressure, caused subarachnoid space (SAS) flow blockage (stenosis), is an underlying cause syrinx and subsequent pain patient. However, paucity detailed vivo pressure data made theoretical explanations difficult to reconcile. In order understand complex...
Recent developments in the field of cellular therapeutics have indicated potential stem cell injections directly to spinal cord. Injections require either open surgery or a Magnetic Resonance Imaging (MRI) guided injection. Needle positioning during MRI imaging is significant hurdle direct injection, as small target region and interlaminar space high accuracy.To improve both procedure time accuracy, an robotic needle system developed.The robot uses linear piezoelectric motors drive parallel...
Abstract The heart is the first organ to develop in human embryo through a series of complex chronological processes, many which critically rely on interplay between cells and dynamic microenvironment. Tight spatiotemporal regulation these interactions key development diseases. Due suboptimal experimental models, however, little known about role microenvironmental cues development. This study investigates use 3D bioprinting perfusion bioreactor technologies create bioartificial constructs...
Cardiovascular magnetic resonance (CMR) cine displacement encoding with stimulated echoes (DENSE) measures heart motion by myocardial into the signal phase, facilitating high accuracy and reproducibility of global segmental strain providing benefits in clinical performance. While conventional methods for analysis DENSE images are faster than those tagging, they still require manual user assistance. The present study developed evaluated deep learning fully-automatic analysis.