A5040472044- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Soft Robotics and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Ultrasonics and Acoustic Wave Propagation
- Tissue Engineering and Regenerative Medicine
- Ultrasound and Cavitation Phenomena
- Electrospun Nanofibers in Biomedical Applications
- Peripheral Artery Disease Management
- Microwave Imaging and Scattering Analysis
- Congenital Heart Disease Studies
- 3D Printing in Biomedical Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Ultrasound in Clinical Applications
- Additive Manufacturing and 3D Printing Technologies
- Surgical Simulation and Training
- Mechanical Circulatory Support Devices
- Congenital heart defects research
- Industrial Gas Emission Control
Georgia Institute of Technology
2017-2024
The Wallace H. Coulter Department of Biomedical Engineering
2018-2024
Emory University
2017-2021
North Carolina State University
2013-2017
University of North Carolina at Chapel Hill
2013-2017
UNC/NCSU Joint Department of Biomedical Engineering
2017
North Central State College
2016
University of North Carolina Health Care
2016
Duke University
2008-2013
Abstract Effective removal or dissolution of large blood clots remains a challenge in clinical treatment acute thrombo-occlusive diseases. Here we report the development an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing required dose drugs. We hypothesize that sub-megahertz, forward-looking ultrasound transducer with integrated microbubble injection tube is more advantageous efficient thrombolysis by enhancing cavitation-induced...
For many years, ultrasound has provided clinicians with an affordable and effective imaging tool for applications ranging from cardiology to obstetrics. Development of microbubble contrast agents over the past several decades enabled distinguish between blood flow surrounding tissue. Current clinical practices using rely heavily on user training evaluate degree localized perfusion. Advances in separating signals produced versus tissue backscatter provide unique opportunities specialized...
Recently, dual-frequency transducers have enabled high-spatial-resolution and high-contrast imaging of vasculature with minimal tissue artifacts by transmitting at a low frequency receiving broadband superharmonic echoes scattered microbubble contrast agents. In this work, we examine the parameters for optimizing contrast-to-tissue ratio (CTR) relationship spatial resolution. Confocal piston are used in water bath setup to measure SNR, CTR, axial resolution ultrasound nonlinear scattering...
Abstract The heart is the first organ to develop in human embryo through a series of complex chronological processes, many which critically rely on interplay between cells and dynamic microenvironment. Tight spatiotemporal regulation these interactions key development diseases. Due suboptimal experimental models, however, little known about role microenvironmental cues development. This study investigates use 3D bioprinting perfusion bioreactor technologies create bioartificial constructs...
Because stroke remains an important and time-sensitive health concern in developed nations, we present a system capable of fusing 3-D transcranial ultrasound volumes acquired from two sides the head. This uses custom sparse array transducers built on flexible multilayer circuits that can be positioned for simultaneous imaging through both temporal acoustic windows, allowing potential registration multiple real-time scans cerebral vasculature. We examine hardware considerations new matrix...
Having previously presented the ultrasound brain helmet, a system for simultaneous 3-D imaging via both temporal bone acoustic windows, scanning geometry of this is utilized to allow each matrix array serve as correction source opposing array. Aberration estimated using cross-correlation RF channel signals, followed by least mean squares solution resulting overdetermined system. Delay maps are updated and real-time resumes. A first attempt made at multiple arrival time correct unique...
Cancers of the pancreas have poorest prognosis among all cancers, as many tumors are not detected until surgery is no longer a viable option. Surgical viability typically determined via endoscopic ultrasound imaging. However, patients who may be eligible for resection offered due to diagnostic challenges in determining vascular or lymphatic invasion. In this paper, we describe development dual-frequency piezoelectric transducer rotational imaging designed transmit at 4 MHz and receive 20...
Vascular atresia are often treated via transcatheter recanalization or surgical vascular anastomosis due to congenital malformations coronary occlusions. The cellular response is, however, largely unknown and current techniques rely on restoration rather than optimization of flow into the atretic arteries. An improved understanding post may result in reduced restenosis. Here, an vitro platform is used model pulmonary arteries (PAs) for procedural planning reduce Bifurcated PAs bioprinted...
Transcranial ultrasound imaging and therapy depend on the efficient transmission of acoustic energy through skull. Multiple previous studies have concluded that a large incidence angle should be avoided during transcranial-focused to ensure Alternatively, some other shown longitudinal-to-shear wave mode conversion might improve skull when is increased above critical (i.e., 25° 30°).The effect porosity at varying angles was investigated for first time elucidate why decreased in cases but...
We present the first multimodal deep learning framework combining ultrasound (US) and electrocardiography (ECG) data to predict cardiac quiescent periods (QPs) for optimized computed tomography angiography gating (CTA). The integrates a 3D convolutional neural network (CNN) US an artificial (ANN) ECG data. A dynamic heart motion phantom, replicating diverse conditions, including arrhythmias, was used validate framework. Performance assessed across varying QP lengths, segments, motions...
A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. carbon black was designed, fabricated and characterized. The prototyped applied in-vitro thrombolysis tests involving microbubble contrast agent (MCA). conventional piezo used as secondary excitation source enhance cavitation effect...
In this paper, a novel dual layer co-linear array ultrasound transducer was developed for transrectal dual-frequency superharmonic imaging. The KLM model and Field II were used the acoustic stack design simulation of field array, respectively. newly designed fabricated probe consists 50 transmit elements with center frequency 3 MHz 100 receive 18 MHz. dimensions are 15 mm in azimuth 9 elevation. pitch is 270 µm transmitting 135 receiving element. Pulse-echo testing TX/RX corresponded...
Approximately 80% of men who reach 80 years age will have some form prostate cancer. The challenge remains to differentiate benign and malignant lesions. Based on recent research, acoustic angiography, a novel contrast-enhanced ultrasound imaging technique, can provide high-resolution visualization tissue microvasculature has demonstrated the ability vascular characteristics between healthy tumor in preclinical studies. We hypothesize that transrectal angiography may enhance assessment In...